Similar studies for GEO DataSets (Select 200008686) - GEO DataSets

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Items: 4

Select item 2000086861.

Gene expression profiling in three primary human cell lines treated with atorvastatin or an inhibitor of Rho kinase

(Submitter supplied) Inhibitors of Rho kinase (ROCK) are a new class of drugs with potential benefit in oncology, neurology, and fibrotic and cardiovascular diseases. ROCK inhibitors modulate many cellular functions, some of which are similar to the pleiotropic (non-lipid lowering) effects of statins, suggesting additive or synergistic properties. Studies to date have used compounds which inhibit both isoforms of ROCK, ROCK1 and ROCK2. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2987
Platform:: GPL2507
36 Samples

Download data: TXT

Series

Accession:: GSE8686

ID:: 200008686

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 29872.

Comparison of Rho kinase inhibitor and atorvastatin effects on primary cell lines

Analysis of three primary cell lines treated with Rho kinase (ROCK) 2 inhibitor SLx-2119 or with atorvastatin. Effects of ROCK inhibitors overlap to some extent with the pleiotropic (nonlipid lowering) effects of statins. Results suggest possible synergistic effects between the two classes of drugs.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 agent, 3 cell line sets

Platform:: GPL2507
Series:: GSE8686
36 Samples

Download data: TXT

DataSet

Accession:: GDS2987

ID:: 2987

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000024503.

Endothelial cells and atorvastatin

(Submitter supplied) Rationale: Immortalized cells may exhibit important differences relative to their primary cell counterparts. Microarrays were used compare primary human umbilical vein endothelial cells (HUVECs) and the immortalized HUVEC cell line EA.hy926, in their response to inhibition of the mevalonate pathway by a HMG-CoA reductase inhibitor (atorvastatin). The effects of atorvastatin were reversed by the addition of mevalonate, to subtract non-specific changes in gene expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS1630
Platform:: GPL96
16 Samples

Download data: CEL, EXP

Series

Accession:: GSE2450

ID:: 200002450

Select item 16304.

Immortalized endothelial cell line response to atorvastatin

Analysis of EA.hy926, an immortalized umbilical vein endothelial cell (HUVEC) line, and its primary cell counterpart following treatment with HMG-CoA reductase inhibitor atorvastatin to inhibit the mevalonate pathway. Results suggest EA.hy926 cells have retained endothelial cell-specific features.