GEO DataSets

(Submitter supplied) Female largemouth bass were injected with 10mg/kg dieldrin and sacrificed after 7 days. Hypothalami were dissected and total RNA extracted for microarray analysis. Exposure to dieldrin induces neurotoxic effects in the vertebrate CNS and disrupts reproductive processes in teleost fish. Reproductive impairment observed in fish is likely the result of multiple mechanisms of action along the hypothalamic-pituitary-gonadal axis. more...

Organism:

Micropterus salmoides

Type:

Expression profiling by array

Platform:

GPL6527

8 Samples

Download data: TXT

(Submitter supplied) This study examines the genomic effects of dieldrin in the hypothalamus of largemouth bass. Dieldrin is an insectide and organic pollutant.

Organism:

Micropterus salmoides

Type:

Expression profiling by array

Platform:

GPL6527

8 Samples

Download data: TXT

(Submitter supplied) Male largemouth bass were injected with 25 mg/kg MXC and sacrificed after 48 hours; liver dissected and used for total RNA extraction Keywords: Methoxychlor injection; single injection and time point The organochlorine pesticide methoxychlor (MXC) (1,1,1-trichloro-2,2-bis(p-methoxyphenyl)ethane) has been used increasingly as an insecticide since the banning of DDT, the primary advantage being that MXC is rapidly metabolized and does not show high levels of bioaccumulation in non-target organisms. more...

Organism:

Micropterus salmoides

Type:

Expression profiling by array

Platform:

GPL6527

8 Samples

Download data: TXT

(Submitter supplied) A goldfish brain enriched cDNA combined with a carp microarray (Gracey et al., 2004). Female adult goldish were treated twice a week for 17 days, for a total of five injections. Each of the injections consisted of 5 μg fluoxetine/g of body weight with an injection volume of 1μl/g. The telencephalon was tissue used. Keywords: i.p.injection of muscimol, 6 hours, pharmacological

Organism:

Carassius auratus; Cyprinus carpio

Type:

Expression profiling by array

Platform:

GPL3735

4 Samples

Download data

(Submitter supplied) Purpose: We aimed to reconstruct the development formation of cellular identities' heterogeneity in the hypothalamus with single-cell RNA sequencing. We planned to track branching process of neurogenesis and follow the formation of cell identities. Results: We integrate single-cell RNA-seq data on 51,199 cells of ectodermal origin, representing critical stages of pre- and postnatal hypothalamus development, supported by anatomical lineage reconstruction to show that bulk neurogenesis in the hypothalamus, dominated by Notch signalling and its interaction with Ascl1, persists until the neonatal period to produce molecularly distinct astrocytes, ependyma, tanycytes and 30 protoclusters of neurons. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

8 Samples

Download data: GRAPHML, RDS, TSV

(Submitter supplied) A novel custom microarray for largemouth bass (Micropterus salmoides) was designed from sequences obtained from a normalized cDNA library using the 454 Life Sciences GS-20 pyrosequencer. The GS-20 yielded in excess of 58 million bases of high-quality sequence. The sequence information was combined with 2,616 reads obtained by traditional suppressive subtractive hybridizations to derive a total of 31,391 unique sequences. more...

Organism:

Micropterus salmoides

Type:

Expression profiling by array

Platform:

GPL6527

16 Samples

Download data: TXT

(Submitter supplied) Sexually mature female goldfish were administered 2 i.p. injections: 1) 0.1% DMSO in 0.6% saline, and; 2) 0.6% saline OR quinpirole (2 ug/g) dissolved in 0.6% saline.

Organism:

Carassius auratus; Cyprinus carpio

Type:

Expression profiling by array

Platform:

GPL3735

4 Samples

Download data: TXT

(Submitter supplied) Sexually mature female goldfish were administered 2 i.p. injections: 1) 0.1% DMSO in 0.6% saline or SKF 38393 (40 µg/g) dissolved in 0.1% DMSO in 0.6% saline, and; 2) 0.6% saline.

Organism:

Carassius auratus; Cyprinus carpio

Type:

Expression profiling by array

Platform:

GPL3735

4 Samples

Download data: TXT