Similar studies for GEO DataSets (Select 200013482) - GEO DataSets

Select item 2000134821.

Expression profiling of zebrafish sox9 mutants reveals that Sox9 is required for retinal differentiation

(Submitter supplied) The transcription factor gene Sox9 plays various roles in development, including differentiation of the skeleton, testes, glia, and heart. Other functions of Sox9 remain enigmatic. Because Sox9 protein regulates expression of target genes, the identification of Sox9 targets should facilitate an understanding of the mechanisms of Sox9 action. To help identify Sox9 targets, we used microarray expression profiling to compare wild-type embryos to mutant embryos lacking activity for sox9a and sox9b, the zebrafish co-orthologs of Sox9. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL7556
6 Samples

Download data: GPR

Series

Accession:: GSE13482

ID:: 200013482

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000118932.

AHR Activation by TCDD Downregulates Sox9b Expression Producing Jaw Malformation in Zebrafish Embryos

(Submitter supplied) Exposure to environmental contaminants can disrupt normal development of the early vertebrate skeleton. 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) impairs craniofacial skeletal development across many vertebrate species and its effects are especially prominent in early life stages of fish. TCDD activates the aryl hydrocarbon receptor (AHR), a transcription factor that mediates most if not all TCDD responses. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL1319
24 Samples

Download data: CEL

Series

Accession:: GSE11893

ID:: 200011893

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000050483.

Gene Expression Profiling of Zebrafish Embryonic Retinal Pigment Epithelium in vivo.

(Submitter supplied) Eye development and photoreceptor maintenance requires the retinal pigment epithelium (RPE), a thin layer of cells that underlies the neural retina. Despite its importance, RPE development has not been studied by a genomic approach. A microarray expression profiling methodology was established in this study for studying RPE development. The intact retina with RPE attached was dissected from developing embryos, and differentially expressed genes in RPE were inferred by comparing the dissected tissues with retinas without RPE using microarray and statistical analyses. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Dataset:: GDS2556
Platform:: GPL1319
6 Samples

Download data: CEL, DAT

Series

Accession:: GSE5048

ID:: 200005048

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 25564.

Embryonic retinal pigment epithelium

Analysis of microdissected embryonic retinas with or without the retinal pigment epithelium (RPE). The RPE is a thin layer of cells that underlies the neural retina and supports the function and development of photoreceptors. Results provide insight into the development of the RPE.

Organism:: Danio rerio

Type:: Expression profiling by array, count, 2 tissue sets

Platform:: GPL1319
Series:: GSE5048
6 Samples

Download data: CEL, DAT

DataSet

Accession:: GDS2556

ID:: 2556

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000502415.

Expression profiling of the retinal pigment epithelium in zebrafish smarca4 mutant

(Submitter supplied) Purpose: The purpose of this study was to develop a framework for analyzing RPE expression profiles from zebrafish eye mutants. Methods: The fish model we used was smarca4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4), a retinal dystrophic mutant that the retinal phenotype and expression profiles were previously characterized. Histological and Affymetrix GeneChip analyses were conducted to define the RPE defects and underlying differential expression respectively. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL1319
18 Samples

Download data: CEL

Series

Accession:: GSE50241

ID:: 200050241

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000700496.

Transcriptional profiling of setb morphants

(Submitter supplied) We have characterised the zebrafish ortholog, setb, and investigated its role in embryogenesis. Phylogenetic analysis showed that zebrafish Setb has an amino acid sequence identity of approximately 96% with the mammalian orthologs. Whole mount immunofluorescence analysis revealed that Setb is expressed mainly in the eye, the lateral line neuromasts and the olfactory pit. Knockdown of setb using antisense morpholino oligonucleotides resulted in increased apoptosis, reduced cell proliferation and severe morphological defects. more...

Organism:: Danio rerio

Type:: Expression profiling by array

Platform:: GPL16933
6 Samples

Download data: CEL

Series

Accession:: GSE70049

ID:: 200070049

Select item 2000463877.

Gene Expression Analysis of Zebrafish Melanocytes, Iridophores, and Retinal Pigmented Epithelium Reveals Indicators of Biological Function and Developmental Origin

(Submitter supplied) In order to facilitate understanding of pigment cell biology, we developed a method to concomitantly purify melanocytes, iridophores, and retinal pigmented epithelium from zebrafish, and analyzed their transcriptomes. Comparing expression data from these cell types and whole embryos allowed us to reveal gene expression co-enrichment in melanocytes and retinal pigmented epithelium, as well as in melanocytes and iridophores. more...

Organism:: Danio rerio

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL15583 GPL14875
35 Samples

Download data: TXT

Series

Accession:: GSE46387

ID:: 200046387

PubMed Full text in PMC Similar studies SRA Run Selector

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