Similar studies for GEO DataSets (Select 200014908) - GEO DataSets

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Items: 11

Select item 2000149081.

Global expression profiling of CD4 T-cell responses to house dust mite allergens in human atopics and nonatopics.

(Submitter supplied) The aim of this study was to employ a systems-level analysis to elucidate gene expression networks operating in the CD4 T-cell responses which underpin human atopic disease. Keywords: Disease state analysis; T-cell response

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
90 Samples

Download data: CEL

Series

Accession:: GSE14908

ID:: 200014908

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000707602.

Gene expression patterns in house dust mite stimulated CD4 T cells and IgG:IgE ratios

(Submitter supplied) PBMC from house dust mite (HDM) sensitized atopics were cultured in the presence or absence of HDM extract for 24 hours. At the termination of the cultures, CD4 T cells were isolated using immunomagnetic separation. Gene expression was profiled on microarrays.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL20171
90 Samples

Download data: CEL, TXT

Series

Accession:: GSE70760

ID:: 200070760

Select item 2001222903.

Rewiring of gene networks underlying mite allergen-induced CD4 + Th-cell responses during immunotherapy

(Submitter supplied) Background: Multiple regulatory mechanisms have been identified employing conventional hypothesis-driven approaches as contributing to allergen-specific immunotherapy outcomes, but understanding of how these integrate to maintain immunological homeostasis is incomplete. Objective: To explore the potential for unbiased systems-level gene co-expression network analysis to advance understanding of immunotherapy mechanisms. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL25487
198 Samples

Download data: CEL, TXT

Series

Accession:: GSE122290

ID:: 200122290

Select item 2000160324.

Gene expression data from severe asthmatic children: PBMC profiles during acute exacerbation versus convalescence

(Submitter supplied) Severe asthma exacerbations in children requiring hospitalisation are typically associated with viral infection, and occur almost exclusively amongst atopics, but the significance of these comorbidities is unknown. We hypothesised that underlying interactions between immunoinflammatory pathways related to responses to aeroallergen and virus are involved, and that evidence of these interactions is detectable in circulating cells during exacerbations. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3615
Platform:: GPL570
10 Samples

Download data: CEL

Series

Accession:: GSE16032

ID:: 200016032

Select item 36155.

Asthma exacerbation and convalescent phases: peripheral blood mononuclear cells

Analysis of peripheral blood mononuclear cells of children with acute asthma during exacerbation and at subsequent convalescence. Severe asthma exacerbations in children are associated with viral infection and occur among atopics. Results provide insight into the significance of these comorbidities.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL570
Series:: GSE16032
10 Samples

Download data: CEL

DataSet

Accession:: GDS3615

ID:: 3615

Select item 2001497796.

Distinct functions of tissue-resident and circulating memory Th2 cells in allergic airway disease

(Submitter supplied) We report RNA-seq data from distinct memory CD4+ T cell subsets in a murine model of allergic asthma.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TXT

Series

Accession:: GSE149779

ID:: 200149779

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000734827.

Gene expression patterns in allergen-driven CD4 T cell responses from human atopics with or without asthma.

(Submitter supplied) PBMC from house dust mite (HDM) sensitized atopics with or without asthma (or nonallergic controls) were cultured in the presence or absence of HDM extract for 24 hours. At the termination of the cultures, immunomagnetic separation was performed to purify CD4 T cells. Gene expression was profiled on microarrays.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL20171
144 Samples

Download data: CEL

Series

Accession:: GSE73482

ID:: 200073482

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000067828.

Natural killer T-cell characterization through gene expression profiling

(Submitter supplied) Natural killer T (NKT) cells are a distinct lymphocyte lineage thought to operate primarily at the interface between the innate and adaptive immune response. Yet, their unique role in the immune system remains elusive. Whilst NKT cells show high similarities to other cells of the innate and adaptive immune system, they express unique functional features such as rapid, concomitant production of Th1 and Th2 cytokines upon TCR ligation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1868
16 Samples

Download data: TIFF, TXT, XML

Series

Accession:: GSE6782

ID:: 200006782

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000449379.

Defining a Th9 transcriptome

(Submitter supplied) Microarray analyses were performed to compare gene expression in cultured mouse Th9, Th2 and Treg cells and resting versus activated Th9 cells.

Organism:: Mus musculus

Type:: Expression profiling by array

Datasets:: GDS5291 GDS5343
Platform:: GPL7202
12 Samples

Download data: TXT

Series

Accession:: GSE44937

ID:: 200044937

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 534310.

T helper type 9 cells stimulated with anti-CD3 antibody

Analysis of naive CD4+ T cells cultured under T helper type 9 (Th9) conditions for 5 days and activated with anti-CD3 antibody. Th9 cells are a subpopulation of CD4+ effector T cells that secrete high levels of interleukin-9. Results provide insight into the molecular basis of the Th9 phenotype.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL7202
Series:: GSE44937
6 Samples

Download data: TXT

DataSet

Accession:: GDS5343

ID:: 5343

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 529111.

T helper type 9 cells

Analysis of naive CD4+ T cells cultured under T helper type 9 (Th9), Th2, or Treg conditions for 5 days. Th9 cells are a subpopulation of CD4+ effector T cells that secrete high levels of interleukin-9. Results provide insight into the molecular basis of the Th9 phenotype.