Similar studies for GEO DataSets (Select 200015268) - GEO DataSets

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Items: 20

Select item 2000152681.

Cell-context dependent Notch target genes

(Submitter supplied) Notch signaling regulates a variety of developmental cell fates decisions in a cell-context dependent manner. Although Notch signaling directly regulates transcription via the RBP-J/CSL DNA binding protein, little is known about the genes in the respective tissues that are directly activated by Notch. To analyze how Notch signaling mediates its context dependent functions, we utilized a Tamoxifen(OHT)-inducible system (NERT) to activate Notch1 in embryonic stem cells (ESC) at different stages of mesodermal differentiation combined with global transcriptional analyses.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
16 Samples

Download data: CEL

Series

Accession:: GSE15268

ID:: 200015268

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000474662.

Notch-HES1 signaling axis controls hemato-endothelial fate decisions of human embyronic and induced pluripotent cells

(Submitter supplied) Notch signaling regulates several cellular processes including cell fate decisions and proliferation in both invertebrates and mice. However, comparatively less is known about the role of Notch during early human development. Here, we examined the function of Notch signaling during hematopoietic lineage specification from human pluripotent stem cells (hPSCs) of both embryonic and adult fibroblast origin. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
8 Samples

Download data: CEL

Series

Accession:: GSE47466

ID:: 200047466

Select item 2000152323.

A Regulatory Pathway Involving Notch1/β-Catenin/Isl1 Determines Cardiac Progenitor Cell Fate

(Submitter supplied) The regulation of multipotent cardiac progenitor cell (CPC) expansion and subsequent differentiation into cardiomyocytes, smooth muscle, or endothelial cells is a fundamental aspect of basic cardiovascular biology and cardiac regenerative medicine. However, the mechanisms governing these decisions remain unclear. Here, we show that Wnt/β-Catenin signaling, which promotes expansion of CPCs, is negatively regulated by Notch1-mediated control of phosphorylated β-Catenin accumulation within CPCs, and that Notch1 activity in CPCs is required for their differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS3811
Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE15232

ID:: 200015232

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 38114.

β-Catenin stabilized cardiac progenitor cells in vivo

Analysis of β-Catenin-stabilized cardiac progenitor cells (CPCs) from E9.0 mutant embryos, before cardiac dysfunction. β-Catenin signaling promotes expansion of multipotent CPCs in vivo. Results provide insight into the molecular mechanisms underlying CPC expansion.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL1261
Series:: GSE15232
6 Samples

Download data: CEL

DataSet

Accession:: GDS3811

ID:: 3811

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000132445.

Identification of Pax6-dependent gene regulatory networks in the mouse lens

(Submitter supplied) This is an integrative genome-wide approach to identify downstream networks controlled by Pax6 during mouse lens and forebrain development. Differential gene expression was analyzed in Pax6 mouse heterozygous and wildtype newborn mouse lenses, with subsequent comparison of this data with Pax6 forebrain expression data (Holm et al., 2007). Keywords: Differential gene expression

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8321
6 Samples

Download data: CEL

Series

Accession:: GSE13244

ID:: 200013244

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000209786.

Activated Notch-induced transcriptional profile modulation in human primary dermal lymphatic endothelial cells

(Submitter supplied) Human Notch1 intracellular domain (NICD) was overexpressed in human primary lymphatic endothelial cells (LECs) for 10 and 24 hours by adenovirus. A GFP-control adenovirus-infected cells (24hours) and uninfected cells were also analysed as controls. Total RNAs were harvested and subjected to Affymetrix U133A microarray.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
4 Samples

Download data

Series

Accession:: GSE20978

ID:: 200020978

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000607477.

Hey target gene regulation in murine ES cells and cardiomyocytes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL1261 GPL11002
16 Samples

Download data: CEL, WIG

Series

Accession:: GSE60747

ID:: 200060747

Select item 2000607468.

Hey target gene regulation in murine ES cells and cardiomyocytes [Affymetrix]

(Submitter supplied) We used an in vitro cardiomyocyte differentiation system with inducible Hey1 or Hey2 expression to study target gene regulation in cardiomyocytes (CM) generated from murine embryonic stem cells (ESC). The effects of Hey1 and Hey2 are largely redundant, but cell type specific. The number of regulated genes is comparable between ESC and CM, but the total number of binding sites is much higher, especially in ESC, targeting mainly genes involved in transcriptional regulation and developmental processes. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
4 Samples

Download data: CEL

Series

Accession:: GSE60746

ID:: 200060746

Select item 2000606999.

Hey target gene regulation in murine ES cells and cardiomyocytes [high throughput sequencing]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11002
12 Samples

Download data: TXT, WIG

Series

Accession:: GSE60699

ID:: 200060699

PubMed Similar studies SRA Run Selector

Select item 20006696110.

Identification of in vivo DNA-binding mechanisms of Pax6 and reconstruction of Pax6-dependent gene regulatory networks during lens and forebrain development

(Submitter supplied) The transcription factor Pax6 is comprised of the paired domain (PD) and homeodomain (HD). In the developing forebrain, Pax6 is expressed in ventricular zone precursor cells and in specific subpopulations of neurons; absence of Pax6 results in disrupted cell proliferation and cell fate specification. Pax6 also regulates the entire lens developmental program. To reconstruct Pax6-dependent gene regulatory networks (GRNs), ChIP-seq studies were performed using lens and forebrain chromatin from mice. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL11002 GPL17021
24 Samples

Download data: BED, NARROWPEAK, TXT

Series

Accession:: GSE66961

ID:: 200066961

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003520811.

Effects of silencing miR-10b in an U87-2M1 glioma line - an invasive in vivo derived subline of U87 glioma cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
12 Samples

Download data: CEL, CHP

Series

Accession:: GSE35208

ID:: 200035208

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003517012.

Expression data from U87-2M1 glioma cells transduced with baculoviral control decoy vector or baculoviral miR-10b decoy vector

(Submitter supplied) MicroRNA-10b may target numerous genes in gliomagenesis. The target genes of miR-10b may differ according to the cellular context. We used microarray analyses to determine the phenotypic effects and gene targets of miR-10b by silencing miR-10b in invasive U87-2M1 glioma cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE35170

ID:: 200035170

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003516913.

Expression data from U87 glioma cells and U87-2M1 glioma cells

(Submitter supplied) An experimental lung metastasis assay was used to derive an invasive subline of U87 that is metastatic in mice. We used microarray analyses to find out over-represented gene ontologies that can explain the observed enhanced invasiveness of U87-2M1 cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE35169

ID:: 200035169

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20001213414.

The transcription factor AP2γ regulates the number of basal progenitors

(Submitter supplied) Understanding the mechanisms that specify neuronal subtypes is important to unravel the complex mechanisms of neuronal circuit assembly. Here we have identified a novel role for the transcription factor AP2γ in progenitor and neuronal subtype specification in the cerebral cortex. Conditional deletion of AP2γ causes misspecification of basal progenitors starting at mid-neurogenesis and gain-of-function experiments show that AP2γ directly regulates the expression of several genes characteristic for basal progenitors, such as Math3 and Tbr2. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
12 Samples

Download data: CEL

Series

Accession:: GSE12134

ID:: 200012134

Select item 20005354215.

Zrf1 is required to establish and maintain neural progenitor identity

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13912 GPL11002
11 Samples

Download data: TXT

Series

Accession:: GSE53542

ID:: 200053542

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005354116.

Zrf1 is required to establish and maintain neural progenitor identity (mRNA array)

(Submitter supplied) Our work aims to characterize the role of Zrf1 in the generation and maintenance of neural progenitor cells (NPCs)

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
8 Samples

Download data: TXT

Series

Accession:: GSE53541

ID:: 200053541

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20005354017.

Zrf1 is required to establish and maintain neural progenitor identity (ChIP-Seq)

(Submitter supplied) We report ChIP-seq data for Zrf1 and Ring1B occupancy in NPC

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11002
3 Samples

Download data: TXT

Series

Accession:: GSE53540

ID:: 200053540

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002833818.

MicroRNA expression during Hematopoiesis

(Submitter supplied) Murine ES cells were grown on confluent OP-9 and differentiated along the hematopoitic lineage. To assess the effects of Notch in hematopoiesis, activated Notch was overexpressed from Day 5 to Day 8.

Organism:: Human alphaherpesvirus 2; Mus musculus cytomegalovirus 2; Homo sapiens; Mus musculus; Human alphaherpesvirus 1; Human betaherpesvirus 5; Human immunodeficiency virus 1; Merkel cell polyomavirus; Rattus norvegicus; human gammaherpesvirus 4; JC polyomavirus; Human gammaherpesvirus 8; Betapolyomavirus macacae; Murid gammaherpesvirus 4; Betapolyomavirus hominis

Type:: Non-coding RNA profiling by array

Platform:: GPL11432
9 Samples

Download data: GPR

Series

Accession:: GSE28338

ID:: 200028338

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013061419.

HES1 and HES4 have both unique and overlapping roles as downstream mediators of Notch-dependent hematopoietic lineage decisions in human

(Submitter supplied) In both mouse and human, Notch1 activation is the main initial driver to induce T-cell development in hematopoietic progenitor cells. The initiation of this developmental process coincides with Notch1-dependent repression of differentiation towards other hematopoietic lineages. Although well described in mice, the role of the individual Notch1 target genes during these hematopoietic developmental choices is still unclear in human. more...