GEO DataSets

(Submitter supplied) In order to address the progression, metastasis, and clinical heterogeneity of renal cell cancer (RCC), transcriptional profiling with oligonucleotide microarrays (22,283 genes) was done on 49 RCC tumors, 20 non-RCC renal tumors, and 23 normal kidney samples. Samples were clustered based on gene expression profiles and specific gene sets for each renal tumor type were identified. Gene expression was correlated to disease progression and a metastasis gene signature was derived. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

92 Samples

Download data: CEL, TXT

(Submitter supplied) In order to clarify the molecular mechanism involved in renal carcinogenesis, and identify molecular targets for diagnosis and treatment, we analyzed genome-wide gene expression profiles of 15 surgical specimens of clear cell renal cell carcinoma (RCC), compared to normal renal cortex, using a combination of laser microbeam microdissection (LMM) with a cDNA microarray representing 27,648 genes.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4747

15 Samples

Download data: TXT

(Submitter supplied) Our goal was to identify gene expression features, using comprehensive gene expression profiling, that correlate with survival in conventional renal cell carcinomas (cRCCs). We profiled 177 cRCCs using high-density cDNA microarrays. Unsupervised hierarchical clustering analysis segregated cRCC into five gene expression subgroups. Expression subgroup was correlated with survival in long-term follow-up and was independent of grade, stage, and performance status. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

10 related Platforms

177 Samples

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(Submitter supplied) Metastasis via the lymphatics is a major risk factor in squamous cell carcinoma of the oral cavity (OSCC). We sought to determine whether the presence of metastasis in the regional lymph node could be predicted by a gene expression signature of the primary tumor. A total of 18 OSCCs were characterized for gene expression by hybridizing RNA to Affymetrix U133A gene chips. Genes with differential expression were identified using a permutation technique and verified by quantitative RT-PCR and immunohistochemistry. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1062

Platform:

GPL96

27 Samples

Download data: CEL

Expression profiling of 18 primary squamous cell carcinomas of the oral cavity with or without lymph node metastasis. Expression in lymph node metastasis also examined. Results used to identify gene expression signature in primary tumors that indicates the presence of lymph node metastasis.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 disease state, 2 tissue sets

Platform:

GPL96

Series:

GSE2280

27 Samples

Download data: CEL

(Submitter supplied) Myc oncogenic signature in Papillary type 2b Keywords: Gene Expression experiment

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4866

47 Samples

Download data: CEL

(Submitter supplied) Identification of genes regulated by the transcription factor HNF4a2 Keywords: ordered

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

8 Samples

Download data: CEL, CHP, EXP

(Submitter supplied) Analysis of gene expression in human embryonic kidney cells HEK293 overexpressing the transcription factors HNF4a2 or mutant forms HNF4a2 C106R and HNF4a2 R154X, which were introduced by FRT/FLP recombination. The analysis was performed 24 hours following 1µg/ml tetracycline treatment to induce the expression of the genes. Results identify HNF4a regulated genes in kidney cells being several of these genes deregulated in renal cell carcinoma. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL96

8 Samples

Download data

(Submitter supplied) The clear cell subtype of renal cell carcinoma (RCC) is the most lethal and prevalent cancer of the urinary system. To investigate the molecular changes associated with malignant transformation in clear cell RCC, the gene expression profiles of matched samples of tumor and adjacent non-neoplastic tissue were obtained from 6 patients. A custom-built cDNA microarray platform was used, comprising 2,292 probes that map to exons of genes and 822 probes for noncoding RNAs mapping to intronic regions. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL3985

48 Samples

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(Submitter supplied) BACKGROUND: Despite the moderate incidence of papillary renal cell carcinoma (PRCC), there is a disproportionately limited understanding of its underlying genetic programs. There is no effective therapy for metastatic PRCC, and patients are often excluded from kidney cancer trials. A morphological classification of PRCC into Type 1 and Type 2 tumors has been recently proposed, but its biological relevance remains uncertain. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1344

Platform:

GPL570

34 Samples

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Analysis of renal tumors from 34 papillary renal cell carcinoma (PRCC) cases. Results identify 2 molecular signatures that correlate with the morphologic classification of PRCC. Molecular class type 1 tumors correlate with excellent survival, while type 2 tumors correlate with poor survival.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 4 disease state, 2 other sets

Platform:

GPL570

Series:

GSE2748

34 Samples

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(Submitter supplied) 80 bladder tumors of different stages, grades and histologies analyzed on costom made cDNA arrays with 10638 gene elements Keywords: parallel sample

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL1479

80 Samples

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(Submitter supplied) Renal cell carcinoma is the most common neoplasm of the adult kidney. A few subtypes of RCC include papillary RCC (pRCC), chromophobe RCC (chRCC) and the benign oncocytoma tumor. In some cases, distinguishing between the RCC subyptes is difficult. We performed a mircroRNA (miRNA) microarray to determine differential miRNA expression between pRCC, chRCC, and oncocytoma.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL10415

15 Samples

Download data: TXT

(Submitter supplied) Recent advancement in cancer research has shown that tumours are highly heterogeneous and multiple phenotypically different cell populations are found in single nodule. Cancer development and tumour growth is driven by specific type of cells - cancer stem cells or tumour initiating cells (CSCs/TICs), which are to be responsible for tumour growth, metastatic spread and drug resistance. This research was designed to verify the presence of tumour initiating cells in renal cancer cell lines. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL13497

9 Samples

Download data: TXT

(Submitter supplied) We performed expression profiling of 36 types of normal human tissues and identified 2,503 tissue-specific genes. We then systematically studied the expression of these genes in cancers by re-analyzing a large collection of published DNA microarray datasets. Our study shows that integration of each gene's breadth of expression (BOE) in normal tissues is important for biological interpretation of the expression profiles of cancers in terms of tumor differentiation, cell lineage and metastasis. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1096

Platform:

GPL96

36 Samples

Download data: CEL, EXP

Expression profiling of 36 types of normal tissue. Each RNA tissue sample pooled from several donors. Results identify tissue specific genes and provide baselines for interpreting gene expression in cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 36 tissue sets

Platform:

GPL96

Series:

GSE2361

36 Samples

Download data: CEL, EXP

(Submitter supplied) Metastatic clear cell renal cell carcinoma (ccRCC) has a poor prognosis and unpredictable course and there are no molecular markers that reliably predict ccRCC metastasis. In this study, specimens from 84 patients with ccRCC were directly cultured in vitro. The primary cultures from 38 of 94 specimens contained more than 90% tumor cells at 4th passages. After identified by immunostaining, the primary cultures of metastatic- and nonmetastatic ccRCC specimens from the age-, gender-matched patients were subjected to cDNA microrray assays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6259

12 Samples

Download data: TXT

(Submitter supplied) It is unknown if gene expression profiles from primary RCC tumors differ from patient-matched metastatic tumors. Thus, we sought to identify differentially expressed genes between patient-matched primary and metastatic RCC tumors in order to understand the molecular mechanisms underlying the development of RCC metastases.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

31 Samples

Download data: CEL

(Submitter supplied) Bladder tumours used to construct a tumour stage classifier Keywords = bladder cancer, disease stages, classification Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS183

Platform:

GPL80

40 Samples

Download data: CEL

(Submitter supplied) Expression profiling of superficial bladder tumours to delineate the expression pattern differences between non-recurring and recurring tumours. Keywords = bladder cancer, superficial, recurrence, prediction Keywords: other

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL80

31 Samples

Download data: CEL