Similar studies for GEO DataSets (Select 200017090) - GEO DataSets

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Items: 4

Select item 2000170901.

Expression data from human adipose stem cells expanded in allogeneic human serum and fetal bovine serum

(Submitter supplied) Human adipose stem cells (ASCs) have been shown, in pre-clinical studies, to have therapeutic applicability in diverse fields, but a standard expansion method for clinical applications remains yet to be established. Isolated ASCs are typically expanded in medium containing fetal bovine serum (FBS). However, sera and other animal-derived culture reagents stage numerous safety issues in clinical therapy, including possible infections and severe immune reactions. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
10 Samples

Download data: CEL

Series

Accession:: GSE17090

ID:: 200017090

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000238512.

Altered Gene Expression in Human Adipose Stem Cells Cultured with Fetal Bovine Serum Compared to Human Supplements

(Submitter supplied) Mesenchymal stromal cells (MSCs) are promising candidates for innovative cell therapeutic applications. For clinical scale manufacturing regulatory agencies recommend to replace fetal bovine serum (FBS) commonly used in MSC expansion media as soon as equivalent alternative supplements are available. We already demonstrated that pooled blood group AB human serum (HS) and thrombin-activated platelet releasate plasma (tPRP) support the expansion of multipotent adipose tissue-derived MSCs (ASCs). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL1708
21 Samples

Download data

Series

Accession:: GSE23851

ID:: 200023851

Select item 2000947733.

Human and feline adipose-derived mesenchymal stem cells have comparable immunomodulatory functions

(Submitter supplied) Adipose-derived mesenchymal stem cells (ASCs) are a promising cell therapy to treat inflammatory and immune-mediated diseases. Development of appropriate pre-clinical animal models is critical to determine safety and attain early efficacy data for the most promising therapeutic candidates. Naturally occurring diseases in cats already serve as valuable models to inform human clinical trials in oncologic, cardiovascular and genetic diseases. more...

Organism:: Felis catus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL23056
3 Samples

Download data: TXT

Series

Accession:: GSE94773

ID:: 200094773

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001114954.

Comparison of Human Bone Marrow Stromal Cells Cultured in Human Platelet Growth Factors and Fetal Bovine Serum

(Submitter supplied) Background: Bone marrow stromal cells (BMSCs) have classically been cultured in media supplemented with 20% fetal bovine serum (FBS). As an alternative to FBS, pooled solvent detergent apheresis platelets, HPGF-C18, was evaluated for BMSC culture. Methods: A comparison of passage 2 BMSC growth revealed that 10% HPGF-C18 produced similar cell numbers as 20% FBS. Marrow aspirates from 5 healthy subjects were cultured for 4 passages in 10% HPGF-C18 or 20% FBS and were analyzed for proliferation, colony formation efficiency (CFE), surface marker expression, suppression of mixed lymphocyte reactions (MLRs), global gene and microRNA expression analysis. more...