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Links from GEO DataSets

Items: 11

1.

Transcriptional signature of Drosophila wing disc regeneration

(Submitter supplied) Research on the ability of certain organisms to reconstruct missing structures of their bodies is still in its infancy, despite numerous efforts performed in multiple species. Using expression profile analyses on different timepoints that cover wound healing and regeneration processes (0, 24 and 72 hours post injury), we studied the regenerative behaviour of fragmented wing imaginal discs of D. melanogaster implanted into adult flies. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by array
Platform:
GPL3797
12 Samples
Download data
Series
Accession:
GSE17408
ID:
200017408
2.

Ets21C sustains a pro-regenerative transcriptional program in blastema cells of Drosophila imaginal discs

(Submitter supplied) An important unanswered question in regenerative biology is to what extent regeneration is accomplished by the reactivation of gene regulatory networks used during development versus the activation of regeneration-specific transcriptional programs. Following damage, Drosophila imaginal discs, the larval precursors of adult structures, can regenerate missing portions by localized proliferation of damage-adjacent tissue. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25244
4 Samples
Download data: H5, MTX, TSV
Series
Accession:
GSE174326
ID:
200174326
3.

RNA-seq of regenerating blastema cells in Drosophila melanogaster

(Submitter supplied) We have carried out eukaryotic whole-genome Illumina RNA-seq of regenerating blastema cells and control undamaged wing imaginal disc cells to identify the differentially expressed genes during regeneration.
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL13304
6 Samples
Download data: TXT
Series
Accession:
GSE101797
ID:
200101797
4.

JAK/STAT coordinates cell proliferation during disc regeneration with Dilp8-mediated developmental delay in Drosophila melanogaster

(Submitter supplied) Regeneration of fragmented Drosophila imaginal discs occurs in an epimorphic manner, involving local cell proliferation at the wound site. Following disc fragmentation, cells at the wound site activate a restoration program through wound healing, regenerative cell proliferation and repatterning of the tissue. However, the interplay of signaling cascades, driving these early reprogramming steps, is not well understood. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by array
Platform:
GPL1322
30 Samples
Download data: CEL, TXT
Series
Accession:
GSE54868
ID:
200054868
5.

Analysis of the trithorax Group (trxG) genes ash2 and ash1 wing imaginal disc transcriptomes.

(Submitter supplied) The absent, small or homeotic discs 2 (ash2) gene, a member of the trithorax Group (trxG) of transcriptional regulators, is functionally related to ash1. However, ASH2 and ASH1 belong to distinct multimeric complexes of unknown composition and it is unclear how they act to regulate transcription. In this study, examination of gene expression profiles in wing imaginal discs from ash2 and ash1 mutants revealed their transcriptomes are very similar and correlate with wing phenotypes. more...
Organism:
Drosophila melanogaster
Type:
Expression profiling by array
Platform:
GPL3797
12 Samples
Download data
Series
Accession:
GSE4923
ID:
200004923
6.

A large-scale, in vivo transcription factor screen defines bivalent chromatin as a key property of regulatory factors mediating Drosophila wing development

(Submitter supplied) ChIP-seq to map enrichment of histone modifications and RNA polymerase II DNA occupancy in imaginal wing discs at 120 h of development.
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17275
8 Samples
Download data: BEDGRAPH
Series
Accession:
GSE59769
ID:
200059769
7.

Wing imaginal disc spatial expression

(Submitter supplied) Wing imaginal discs were dissected to generate body wall and wing/hinge fragments. Targets from three biological replicates of each were generated and the expression profiles were determined using Affymetrix Drosophila Genechip 1 arrays. Comparisons between the sample groups allow the identification of genes with localized expression patterns. Keywords = Drosophila, wing disc, spatially restricted transcripts Keywords: repeat sample
Organism:
Drosophila melanogaster
Type:
Expression profiling by array
Dataset:
GDS192
Platform:
GPL72
6 Samples
Download data
Series
Accession:
GSE93
ID:
200000093
8.
Full record GDS192

Wing imaginal disc spatial gene expression

Discovery of genes with restricted expression patterns in wing disc and potential roles in wing disc development. Wing imaginal discs dissected to generate body wall and wing/hinge fragments. Three biological replicates of each examined.
Organism:
Drosophila melanogaster
Type:
Expression profiling by array, count, 2 tissue sets
Platform:
GPL72
Series:
GSE93
6 Samples
Download data
DataSet
Accession:
GDS192
ID:
192
9.

Differential gene expression analysis identified determinants of cell fate plasticity during radiation-induced regeneration in Drosophila

(Submitter supplied) We used here a combination of lineage tracing, FACS and genome-wide RNAseq to identify two key changes that accompany hinge-to-pouch fate change: (1) repression of hinge determinants and (2) upregulation of ribosome biogenesis.
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19132
12 Samples
Download data: TXT
Series
Accession:
GSE182782
ID:
200182782
10.

Inducible degradation of the Mediator subunit Med19 reveals a dedicated role in the regulation of developmental genes expression

(Submitter supplied) In the Drosophila wing imaginal disc, by using a inductible degradable version of Med19 degradation with RNAseq, we got access to the early consequences of Med19 depletion on gene expression. We showed that less than a quarter of the genes expressed in the wing disc were deregulated after Med19 loss. Strikingly, these genes exhibit a spatio-temporal expression pattern like transcription factors or Notch responsive genes that reveals Med19 dedicated role in the regulation of developmental gene transcription.
Organism:
Drosophila melanogaster
Type:
Expression profiling by high throughput sequencing
Platform:
GPL25244
9 Samples
Download data: XLSX
Series
Accession:
GSE178125
ID:
200178125
11.

The pioneer transcription factor Zelda facilitates the exit from regeneration and restoration of patterning in Drosophila

(Submitter supplied) For a damaged tissue to regenerate, the injured site must repair the wound, proliferate, and restore the correct patterning and cell types. We found that Zelda, a pioneer transcription factor largely known for its role in embryonic zygotic genome activation, is dispensable for normal wing development but crucial for wing disc patterning during regeneration. Impairing Zelda function during disc regeneration resulted in adult wings with a plethora of cell fate errors, affecting the veins, margins, and posterior compartment identity. more...
Organism:
Drosophila melanogaster
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL25244
8 Samples
Download data: BED, BIGWIG, NARROWPEAK
Series
Accession:
GSE268674
ID:
200268674
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