GEO DataSets

(Submitter supplied) Infectious pneumonias exact an unacceptable mortality burden worldwide. Efforts to protect populations from pneumonia have historically focused on antibiotic development and vaccine-enhanced adaptive immunity. However, we have recently reported that the lungs’ innate defenses can be therapeutically induced by inhalation of a bacterial lysate that protects mice against otherwise lethal pneumonia. Here, we tested in mice the hypothesis that Toll-like receptors (TLRs) are required for this antimicrobial phenomenon, and found that resistance could not be induced in the absence of the TLR signaling adaptor protein MyD88. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

22 Samples

Download data: TXT

(Submitter supplied) Infectious pneumonias exact an unacceptable mortality burden worldwide. Efforts to protect populations from pneumonia have historically focused on antibiotic development and vaccine-enhanced adaptive immunity. However, we have recently reported that the lungs’ innate defenses can be therapeutically induced by inhalation of a combination of synthetic TLR ligands that synergize to protect mice against otherwise lethal pneumonia. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

32 Samples

Download data: TXT

(Submitter supplied) Pneumonia is a serious problem worldwide. We recently demonstrated that innate defense mechanisms of the lung are highly inducible against pneumococcal pneumonia. To determine the breadth of protection conferred by stimulation of lung mucosal innate immunity, and to identify cells and signaling pathways activated by this treatment, mice were treated with an aerosolized bacterial lysate, then challenged with lethal doses of bacterial and fungal pathogens. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6105

12 Samples

Download data: TXT

(Submitter supplied) Rationale: Lower respiratory tract infections continue to exact unacceptable worldwide mortality, often because the infecting pathogen cannot be identified. The respiratory epithelia provide protection from pneumonias through organism-specific generation of antimicrobial products, offering potential insight into the identity of infecting pathogens. Objective: This study assesses the capacity of the host gene expression response to infection to predict lower respiratory pathogens without reliance on culture data. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6099

84 Samples

Download data: TXT

(Submitter supplied) Microglia are the resident mononuclear phagocytes of the CNS parenchyma and represent an initial line of defense against invading microorganisms. Microglia utilize Toll-like receptors (TLRs) for pathogen recognition and TLR2 specifically senses conserved motifs of gram-positive bacteria including lipoproteins, lipoteichoic acids, and peptidoglycan (PGN) leading to cytokine/chemokine production. Interestingly, primary microglia derived from TLR2 knockout (KO) mice over-expressed numerous IL-12 family members, including IL-12p40, IL-12p70, and IL-27 in response to intact S. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6885

11 Samples

Download data: TXT

(Submitter supplied) Study the Role of Surfactant Protein C in Innate Lung Defense.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4876

Platform:

GPL1261

4 Samples

Download data: CEL

Analysis of alveolar type II epithelial cells (AEC II) from mutants deficient for surfactant protein-C (SP-C). SP-C is a surfactant-associated protein secreted by AEC II cells. Results provide insight into the basis of the progressive lung inflammation and remodeling observed in SP-C null mutants.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 genotype/variation sets

Platform:

GPL1261

Series:

GSE35989

4 Samples

Download data: CEL

(Submitter supplied) Leukemia inhibitory factor (LIF) is amongst the IL-6 family cytokines expressed in the lungs during pneumonia. However, the function of endogenous LIF during pneumonia has never been explored. The purpose of this study was to determine the transcriptional response to pneumonia in the lungs and whether or how this response is influenced by LIF. Mice received intratracheal instillations of vehicle (PBS) or Escherichia coli (10^6 CFU). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4583

Platform:

GPL11078

9 Samples

Download data: CEL

Analysis of lung from C57BL/6 animals during E. coli pneumonia in the presence of neutralizing anti-leukemia inhibitory factor (LIF) antibody. Anti-LIF exacerbates lung injury. Results provide insight into molecular mechanisms underlying the pathophysiology of pneumonia.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 infection, 2 protocol sets

Platform:

GPL11078

Series:

GSE34901

9 Samples

Download data: CEL