Similar studies for GEO DataSets (Select 200034928) - GEO DataSets

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Items: 2

Select item 2000349281.

Gene Expression in Normal and Tumor Ovarian Epithelial Cells from Non-carriers and Heterozygous Carriers of a BRCA French Canadian Mutation.

(Submitter supplied) We hypothesized that the transcriptome of primary cultures of morphologically normal ovarian surface epithelial cells could be altered by the presence of a heterozygous BRCA1 or BRCA2 mutation. We aimed to discover early events associated to ovarian carcinogenesis, which could represent putative targets for preventive strategies of this silent killer tumor. We identified the first molecular signature associated with French Canadian BRCA1 or BRCA2 founder mutations in morphologically normal ovarian epithelial cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL80
13 Samples

Download data: CEL

Series

Accession:: GSE34928

ID:: 200034928

Select item 2000193832.

Altered gene expression in normal breast and ovarian epithelial cells from BRCA1 and BRCA2 mutation carriers

(Submitter supplied) Early genetic changes during cancer initiation may provide targets for agents that delay, or even prevent, cancer. We hypothesized that cells bearing a single inherited “hit” in a tumor suppressor gene express an altered mRNA repertoire that may identify targets for measures that could delay or even prevent progression to carcinoma. Here, we report on the transcriptomes of primary breast and ovarian epithelial cells cultured from BRCA1 and BRCA2 mutation-carriers and controls. more...