Similar studies for GEO DataSets (Select 200037683) - GEO DataSets

Select item 2000376831.

Identification of an intrahepatic transcriptional signature associated with self-limiting infection in the woodchuck model of hepatitis B

(Submitter supplied) The woodchuck model of hepatitis B virus (HBV) infection displays many characteristics of human infection and has particular value for characterizing the host immune responses during the development of chronic infection. Using the newly developed custom woodchuck microarray platform, we compared the intrahepatic transcriptional responses of neonatal woodchucks with self-limiting and progressing persistent infection with woodchuck hepatitis virus (WHV). more...

Organism:: Marmota monax

Type:: Expression profiling by array

Platform:: GPL15354
124 Samples

Download data: PAIR

Series

Accession:: GSE37683

ID:: 200037683

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000715822.

Intrahepatic transcriptional signature associated with response to interferon-a treatment in the woodchuck model of chronic hepatitis B

(Submitter supplied) To define the intrahepatic cellular and molecular characteristics of the antiviral response to wIFN-alpha in woodchuck, the transcriptional profiles of woodchuck liver were studied by using RNASeq

Organism:: Marmota monax

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20757
203 Samples

Download data: FASTA, TXT

Series

Accession:: GSE71582

ID:: 200071582

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000679353.

Sustained Efficacy and Seroconversion with the Toll-Like Receptor 7 Agonist GS-9620 in the Woodchuck Model of Chronic Hepatitis B

(Submitter supplied) Background & Aims: New therapies for chronic hepatitis B (CHB) are urgently needed since current treatments rarely lead to cure. We evaluated whether the oral small molecule toll-like receptor (TLR7) agonist GS-9620 could induce durable anti-viral efficacy in woodchucks chronically infected with woodchuck hepatitis virus (WHV), a hepadnavirus closely related to human hepatitis B virus (HBV). Methods: After evaluating the pharmacokinetics, pharmacodynamics and tolerability of oral GS-9620 in uninfected woodchucks, adult woodchucks chronically infected with WHV (n=7 per group) were dosed with GS-9620 or placebo for 4 or 8 weeks with different treatment schedules. more...

Organism:: Marmota monax

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20052
62 Samples

Download data: FA, TXT

Series

Accession:: GSE67935

ID:: 200067935

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000365454.

Transcriptomic analysis of the woodchuck model of chronic hepatitis B: Liver gene expression in tumor and non-tumor samples from chronically infected woodchucks

(Submitter supplied) The Eastern woodchuck (Marmota monax) is naturally infected with woodchuck hepatitis virus (WHV), a hepadnavirus closely related to the human hepatitis B virus (HBV). The woodchuck is used as an animal model for studying chronic hepatitis B (CHB) and HBV-associated hepatocellular carcinoma (HCC) in humans, but the lack of sequence information has hitherto precluded functional genomics analysis. To address this major limitation of the model, we report here the sequencing, assembly and annotation of the woodchuck transcriptome, together with the generation of custom woodchuck microarrays. more...

Organism:: Marmota monax

Type:: Expression profiling by array

Platform:: GPL15354
102 Samples

Download data: PAIR

Series

Accession:: GSE36545

ID:: 200036545

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000365445.

Transcriptomic analysis of the woodchuck model of chronic hepatitis B: Spleen gene expression in uninfected, resolved and chronically infected woodchucks

(Submitter supplied) The Eastern woodchuck (Marmota monax) is naturally infected with woodchuck hepatitis virus (WHV), a hepadnavirus closely related to the human hepatitis B virus (HBV). The woodchuck is used as an animal model for studying chronic hepatitis B (CHB) and HBV-associated hepatocellular carcinoma (HCC) in humans, but the lack of sequence information has hitherto precluded functional genomics analysis. To address this major limitation of the model, we report here the sequencing, assembly and annotation of the woodchuck transcriptome, together with the generation of custom woodchuck microarrays. more...

Organism:: Marmota monax

Type:: Expression profiling by array

Platform:: GPL15354
30 Samples

Download data: PAIR

Series

Accession:: GSE36544

ID:: 200036544

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000365416.

Transcriptomic analysis of the woodchuck model of chronic hepatitis B: Kidney gene expression in uninfected, resolved and chronically infected woodchucks

(Submitter supplied) The Eastern woodchuck (Marmota monax) is naturally infected with woodchuck hepatitis virus (WHV), a hepadnavirus closely related to the human hepatitis B virus (HBV). The woodchuck is used as an animal model for studying chronic hepatitis B (CHB) and HBV-associated hepatocellular carcinoma (HCC) in humans, but the lack of sequence information has hitherto precluded functional genomics analysis. To address this major limitation of the model, we report here the sequencing, assembly and annotation of the woodchuck transcriptome, together with the generation of custom woodchuck microarrays. more...

Organism:: Marmota monax

Type:: Expression profiling by array

Platform:: GPL15354
36 Samples

Download data: PAIR

Series

Accession:: GSE36541

ID:: 200036541

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000365337.

Transcriptomic analysis of the woodchuck model of chronic hepatitis B: Liver gene expression in uninfected, resolved and chronically infected woodchucks

(Submitter supplied) The Eastern woodchuck (Marmota monax) is naturally infected with woodchuck hepatitis virus (WHV), a hepadnavirus closely related to the human hepatitis B virus (HBV). The woodchuck is used as an animal model for studying chronic hepatitis B (CHB) and HBV-associated hepatocellular carcinoma (HCC) in humans, but the lack of sequence information has hitherto precluded functional genomics analysis. To address this major limitation of the model, we report here the sequencing, assembly and annotation of the woodchuck transcriptome, together with the generation of custom woodchuck microarrays. more...