Similar studies for GEO DataSets (Select 200043610) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2000436101.

Dual Roles of the Transcription Factor Grainyhead-like 2 (GRHL2) in Breast Cancer

(Submitter supplied) Using a retrovirus-mediated cDNA expression cloning approach we identified the grainyhead-like 2 (GRHL2) transcription factor as novel protooncogene. Overexpression of GRHL2 in NIH3T3 cells induced striking morphological changes, an increase in cell proliferation, anchorage-independent growth, and tumor growth in vivo. By combining a microarray analysis and a phylogenetic footprinting analysis with various biochemical assays we identified the epidermal growth factor receptor family member Erbb3 as a novel GRHL2 target gene. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7202
6 Samples

Download data: TXT

Series

Accession:: GSE43610

ID:: 200043610

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000360812.

Effect of GRHL2 in HMLE+Twist-ER+4-OHT cells

(Submitter supplied) Grainyhead genes are involved in wound healing and developmental neural tube closure. In light of the high degree of similarity between the epithelial-mesenchymal transitions (EMTs) occurring in wound healing processes and the cancer stem cell-like compartment of tumors, including TGF-β-dependence, we investigated the role of a Grainyhead gene (GRHL2) in oncogenic EMT. Grainyhead was specifically down-regulated in the claudin-low subclass of mammary tumors and in the basal-B subclass of breast cancer cell lines. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
6 Samples

Download data: CEL

Series

Accession:: GSE36081

ID:: 200036081

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000710193.

Grainyhead-like 2 (GRHL2) maintains the epithelial status of ovarian cancer through miR-200-ZEB1 regulatory networks

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9052 GPL16686
13 Samples

Download data: CEL

Series

Accession:: GSE71019

ID:: 200071019

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000710184.

Grainyhead-like 2 (GRHL2) maintains the epithelial status of ovarian cancer through miR-200-ZEB1 regulatory networks (ChIP-Seq)

(Submitter supplied) Epithelial ovarian cancer (EOC) is clinically heterogeneous, comprising different histological and biological subtypes. Multiple studies have implicated epithelial-mesenchymal transition (EMT), a biological process by which polarized epithelial cells convert into a mesenchymal phenotype, to contribute significantly to this molecular heterogeneity of EOC. From gene expression analyses of a collection of EMT-characterized EOC cell lines, we found that the expression of the transcription factor Grainyhead-like 2 (GRHL2) correlates with E-cadherin expression and the epithelial phenotype. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
6 Samples

Download data: XLSX

Series

Accession:: GSE71018

ID:: 200071018

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000710175.

Grainyhead-like 2 (GRHL2) maintains the epithelial status of ovarian cancer through miR-200-ZEB1 regulatory networks (expression)

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
7 Samples

Download data: CEL

Series

Accession:: GSE71017

ID:: 200071017

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002223536.

Dynamic changes in gene transcription in response to GRHL2 knockout in MCF7 cells

(Submitter supplied) Genome-wide dynamic changes in DNA transcription triggered by GRHL2 loss were investigated by Bru-seq measuring nacent RNA at different time points after GRHL2 deletion in a conditional Cas9 MCF7 knockout model expressing a control or 2 different GRHL2 sgRNAs (sgCTR, sgGRHL2(1) and sgGRHL2(2), respectively).

Organism:: Homo sapiens

Type:: Other

Platform:: GPL24676
15 Samples

Download data: BED

Series

Accession:: GSE222353

ID:: 200222353

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001061307.

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure

(Submitter supplied) Aim: Identify molecular pathways controlling palate closure Methods: First pharygneal arch of wild-type and Grhl2-/- e10.5 moues embryos was subjected to RNAseq Results: Grhl2-/- PA1 displayed a shift from epithelial to mesenchymal gene expression Conclusions: Grhl2 maintains epithelial cellular identity during palate closure

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18480
10 Samples

Download data: CSV

Series

Accession:: GSE106130

ID:: 200106130

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000901328.

Suppression of the grainyhead transcription factor 2 gene (GRHL2) inhibits the proliferation, migration, invasion and mediates cell cycle arrest of ovarian cancer cells

(Submitter supplied) Previously, we have identified cytosolic form of the grainyhead transcription factor 2 gene (GRHL2) as notably hypomethylated in low-malignant potential (LMP) and high-grade (HG) serous epithelial ovarian tumors, compared to normal ovarian tissues. Here we show that GRHL2 is strongly overexpressed in both LMP and HG serous EOC tumors, thus suggesting that epigenetic mechanisms might be implicated in GRHL2 overexpression in serous epithelial ovarian cancer (EOC). more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
12 Samples

Download data: TXT

Series

Accession:: GSE90132

ID:: 200090132

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000407299.

Grhl2 regulated genes in the mouse lung epithelial MLE15 cell line

(Submitter supplied) The Grainyhead family of transcription factors controls morphogenesis and differentiation of epithelial cell layers in multicellular organisms by regulating cell junction- and proliferation-related genes. Grainyhead-like 2 (Grhl2) is expressed in developing mouse lung epithelium and is required for normal lung organogenesis. The specific epithelial cells expressing Grhl2 and the genes regulated by Grhl2 in normal lungs are mostly unknown. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS5113
Platform:: GPL6246
5 Samples

Download data: CEL

Series

Accession:: GSE40729

ID:: 200040729

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 511310.

Transcription factor Grainyhead-like 2 depletion effect on lung epithelial cell line

Analysis of MLE-15 lung epithelial cells depleted for Grainyhead-like 2. Results provide insight into the role of Grainyhead-like 2 in the morphogenesis and differentiation of lung epithelial cells.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL6246
Series:: GSE40729
5 Samples

Download data: CEL

DataSet

Accession:: GDS5113

ID:: 5113

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20004686911.

Gene expression profiles of PIK3CA knockdown by shRNA in lung cancer cells

(Submitter supplied) To gain insight into EMT-independent biological processes through which PI3K promotes invasion, RNA samples from 344SQ_p110α shRNA cells and 344SQ_scr cells were subjected to global transcriptional profiling.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE46869

ID:: 200046869

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012648712.

Alterations in GRHL2-OVOL2-ZEB1 Axis and Aberrant Activation of Wnt Signaling Lead to Altered Gene Transcription in Posterior Polymorphous Corneal Dystrophy

(Submitter supplied) To investigate the molecular basis of posterior polymorphous corneal dystrophy (PPCD) by examining the transcriptome in an affected individuals with an OVOL2 promoter mutation c.307T>C (PPCD1).

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
2 Samples

Download data: XLS

Series

Accession:: GSE126487

ID:: 200126487

Select item 20005680113.

Jagged1 regulates miRNA expression profile

(Submitter supplied) miRNA expression profiles of HMECs treated with 40mM Jagged1 (JAG1) or the control peptide for 1 day

Organism:: Homo sapiens

Type:: Other

Platform:: GPL18572
2 Samples

Download data: TXT

Series

Accession:: GSE56801

ID:: 200056801

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20003511814.

Primary TNBC tumor in the presence or absence of SHP2

(Submitter supplied) The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix receptors. In malignancies, SHP2 is hyperactivated either downstream of oncoproteins or by mutations.We provide analysis of a primary triple-negative breast tumor grown as xenografts in the presence or absence of SHP2 for 30 days.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
14 Samples

Download data: CEL

Series

Accession:: GSE35118

ID:: 200035118

Select item 20003452515.

BT474 tumors, primary TN tumors and MCF10A-HER2/3 cells in the presence or absence of SHP2

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
36 Samples

Download data: CEL

Series

Accession:: GSE34525

ID:: 200034525

Select item 20003452416.

MCF10A-HER2/3 cells grown in 3D cultures in the presence or absence of SHP2

(Submitter supplied) The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix receptors. In malignancies, SHP2 is hyperactivated either downstream of oncoproteins or by mutations.We provide analysis of the mammary epithelial cells MCF10A overexpressing human HER2 and HER3 and grown in 3D cultures for 15 days in the presence or absence of SHP2.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL

Series

Accession:: GSE34524

ID:: 200034524

Select item 20003452317.

BT474 tumors in the presence or absence of SHP2

(Submitter supplied) The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix receptors. In malignancies, SHP2 is hyperactivated either downstream of oncoproteins or by mutations.We provide analysis of the breast cancer cells BT474 grown as xenografts in the presence or absence of SHP2 for 30 days.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
16 Samples

Download data: CEL

Series

Accession:: GSE34523

ID:: 200034523

Select item 20024185418.

Grainyhead-like-2, an epithelial master programmer, promotes interferon induction and suppresses breast cancer recurrence

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20301
20 Samples

Download data: NARROWPEAK

Series

Accession:: GSE241854

ID:: 200241854

PubMed Similar studies

Select item 20024185319.

Grainyhead-like-2, an epithelial master programmer, promotes interferon induction and suppresses breast cancer recurrence [ATAC-seq]

(Submitter supplied) Type-I and -III interferons play a central role in immune rejection of pathogens and tumors, thus promoting immunogenicity and suppressing tumor recurrence. Differentiation of embryonic stem cells to pluripotent epithelial cells activates the interferon response during development, raising the question of whether epithelial vs. mesenchymal gene signatures in cancer potentially regulate the interferon pathway as well. more...