Similar studies for GEO DataSets (Select 200049568) - GEO DataSets

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Items: 20

Select item 2000495681.

Signal Transducer and Activator of Transcription 3 limits Epstein-Barr virus lytic-activation in B lymphocytes.

(Submitter supplied) We used microarrays to identify genes differentially expressed in EBV-infected human B cells supporting lytic replication vs. those refractory to EBV lytic replication.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
2 Samples

Download data: CEL, CHP

Series

Accession:: GSE49568

ID:: 200049568

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001412202.

Nascent transcriptomics reveal cellular pro-lytic factors upregulated upstream of the latency-to-lytic switch protein of Epstein-Barr virus

(Submitter supplied) Lytic activation from latency is a key transition point in the life cycle of herpesviruses. Epstein-Barr virus (EBV) is a human herpesvirus that can cause lymphomas, epithelial cancers, and other diseases, most of which require the lytic cycle. While the lytic cycle of EBV can be triggered by chemicals and immunologic ligands, the lytic cascade is only activated when expression of the EBV latency-to-lytic switch protein ZEBRA is turned on. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL16791
12 Samples

Download data: TXT

Series

Accession:: GSE141220

ID:: 200141220

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000738873.

Identification of MEF2B, EBF1, and IL6R as chromosome bound targets of EBNA1 essential for EBV infected B-lymphocyte survival

(Submitter supplied) EBNA1 is the EBV-encoded nuclear antigen required for viral episome maintenance during latency. EBNA1 is a sequence specific DNA binding protein with high affinity binding sites for the viral genome, especially OriP. EBNA1 can also bind sequence specifically to a large number of sites in the host cellular genome, but the function of these binding sites has remained elusive. EBNA1 is also known to provide a host cell survival function, but the molecular mechanisms accounting for this function are not completely understood. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL16791 GPL9115
12 Samples

Download data: TXT

Series

Accession:: GSE73887

ID:: 200073887

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Select item 2001489104.

Transcriptome analysis of CHAF1B depletion in Akata EBV+ Burkitt Lymphoma cells

(Submitter supplied) RNAseq was used to identify host and EBV viral transcriptome changes in CHAF1B knock-out Akata EBV+ cells. CHAF1B KO Akata EBV+ cells were subjected to RNAseq analysis. The Akata EBV+ cells expressing control sgRNA was used as the control.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: CSV

Series

Accession:: GSE148910

ID:: 200148910

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Select item 2001259745.

RNA-seq analysis of EBV transformation of primary resting B cells

(Submitter supplied) RNA profile changes in primary resting B cells after EBV infection

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
21 Samples

Download data: CSV

Series

Accession:: GSE125974

ID:: 200125974

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Select item 2001406536.

MYC controls Epstein Barr virus lytic switch

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
30 Samples

Download data

Series

Accession:: GSE140653

ID:: 200140653

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Select item 2001406527.

Transcriptome analysis of xenograft tumors treated with vehicle control or CBL0137

(Submitter supplied) RNAseq was used to identify host and viral transcriptome changes in xenograft tumors treated with DMSO or CBL0137. Mouse xenograft experiments were regulated by Institutional Animal Care & Use Committee (IACUC# 2017-0035) of Weill Cornell Medical Center(WCMC). Non-obese diabetic/severe combined immunodeficiency (NOD-SCID) mice were obtained from Jackson Laboratories. Six to eight-week-old male and female mice (10 male/18 female) were injected in the flank with 1 x 107 BL cells in PBS with Matrigel eleven days before the treatment. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
6 Samples

Download data: XLSX

Series

Accession:: GSE140652

ID:: 200140652

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Select item 2001406518.

Transcriptome analysis of P3HR-1 cells expressing control, smc1a, supt16h, med12, or tada2b sgRNAs and Akata EBV+ cells expressing control or myc sgRNAs

(Submitter supplied) To gain insights into how EBV latency is maintained, we performed a human genome-wide CRISPR screen in latently EBV-infected Burkitt lymphoma B-cells. Our analyses identified a network of host factors that repress EBV lytic reactivation, centered on the transcription factor MYC and including cohesins, FACT, STAGA and Mediator. RNAseq was used to identify host and viral transcriptome changes in P3HR-1 Burkitt lymphoma cells expressing control, smc1a, supt16h, med12, or tada2b sgRNAs. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
24 Samples

Download data: CSV

Series

Accession:: GSE140651

ID:: 200140651

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000681229.

New non-coding lytic transcripts derived from the Epstein Barr virus latency origin of replication oriP are hyper-edited, bind the paraspeckle protein, NONO/p54nrb, and support lytic viral transcription

(Submitter supplied) We have previously shown that the Epstein-Barr virus (EBV) likely encodes hundreds of viral long non-coding RNAs (vlncRNAs) that are expressed during reactivation. Here we show that the EBV latency origin of replication (oriP) is transcribed bi-directionally during reactivation and that both leftward (oriPtLs) and rightward transcripts (oriPtRs) are largely localized in the nucleus. While the oriPtLs are most likely non-coding, at least some of the oriPtRs contain the BCRF1/vIL10 open reading frame. more...

Organism:: human gammaherpesvirus 4

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20090
16 Samples

Download data: XLS

Series

Accession:: GSE68122

ID:: 200068122

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20013579410.

Changes in cellular transcriptome in response to inhibitors of Epstein-Barr virus

(Submitter supplied) Burkitt lymphoma cells can be latently infected with Epstein-Barr virus (EBV). The virus may be activated into its lytic cycle by small molecules, such as sodium butyrate. Other molecules, such as valproate and valpromide, block viral lytic reactivation. These pharmacological agents alter the cellular physiology that controls viral lytic gene expression. Changes in the cellular transcription were measured in response to one activator and two inhibitors of the Epstein-Barr virus lytic cycle in order to identify cellular genes that are potential regulators of the viral life cycle.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
12 Samples

Download data: TXT

Series

Accession:: GSE135794

ID:: 200135794

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Select item 20017149411.

Defective Epstein-Barr Virus Genomes and Atypical Viral Gene Expression in B-Cell Lines Derived from Multiple Myeloma Patients [III]

(Submitter supplied) Epstein-Barr virus (EBV) is a human gamma-herpesvirus that is causally associated with various lymphomas and carcinomas. Although EBV is not typically associated with multiple myeloma (MM), it can be found in some B-cell lines derived from multiple myeloma patients. Here, we analyzed two EBV+ MM-patient derived cell lines IM9 and ARH77 and found defective viral genomes and atypical viral gene expression patterns. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL18573
2 Samples

Download data: TXT

Series

Accession:: GSE171494

ID:: 200171494

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016519612.

Defective Epstein-Barr Virus Genomes and Atypical Viral Gene Expression in B-Cell Lines Derived from Multiple Myeloma Patients

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL18573
17 Samples

Download data

Series

Accession:: GSE165196

ID:: 200165196

PubMed Full text in PMC Similar studies

Select item 20016519513.

Defective Epstein-Barr Virus Genomes and Atypical Viral Gene Expression in B-Cell Lines Derived from Multiple Myeloma Patients [II]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
12 Samples

Download data: TXT

Series

Accession:: GSE165195

ID:: 200165195

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Select item 20016519414.

Defective Epstein-Barr Virus Genomes and Atypical Viral Gene Expression in B-Cell Lines Derived from Multiple Myeloma Patients [I]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
3 Samples

Download data: TXT

Series

Accession:: GSE165194

ID:: 200165194

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20003070915.

Genome-Wide Analysis of Host-Chromosome Binding Sites for Epstein-Barr Virus Nuclear Antigen 1 (EBNA1)

(Submitter supplied) The Epstein-Barr Virus (EBV) Nuclear Antigen 1 (EBNA1) protein is required for the establishment of EBV latent infection in proliferating B-lymphocytes. EBNA1 is a multifunctional DNA-binding protein that stimulates DNA replication at the viral origin of plasmid replication (OriP), regulates transcription of viral and cellular genes, and tethers the viral episome to the cellular chromosome. EBNA1 also provides a survival function to B-lymphocytes, potentially through its ability to alter cellular gene expression. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9115
2 Samples

Download data: BED

Series

Accession:: GSE30709

ID:: 200030709

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20023748416.

Understanding differential expression of genes during EBV lytic cycle reactivation by employing high throughput RNA-sequencing

(Submitter supplied) To understand the changes in global transcriptomic landscape during the EBV lytic cycle reactivation from lymphoblastoid cell lines (LCLs), RNA-seq was performed. By examining the transcriptomic changes, we obtained valuable insights into the molecular events and regulatory mechanisms involved in EBV reactivation into lytic cycle replication. The study also enhances our knowledge of the complex interplay between EBV and the host cells during its lytic cycle.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24014
6 Samples

Download data: XLSX

Series

Accession:: GSE237484

ID:: 200237484

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20023594117.

Whole transcriptome analysis of EBV infected peripheral blood mononuclear cells (PBMCs)

(Submitter supplied) In order to gain insights into the intricate molecular alterations taking place following Epstein-Barr virus (EBV) infection in primary B-cells, we employed RNA-Seq to investigate the dynamic changes occurring within the cell transcriptome during the early stages of EBV infection (0, 2, and 4 days post infection). By analysing the transcriptomic data generated, our objective was to find novel pathways and mechanisms that may play pivotal roles in the EBV-induced transformation of B-cells, particularly during early stage of B-cell activation.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18573
5 Samples

Download data: XLSX

Series

Accession:: GSE235941

ID:: 200235941

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20020270118.

The Epstein-Barr virus hijacks BRD7 to conquer c-Myc-mediated viral latency maintenance via chromatin remodeling

(Submitter supplied) The Epstein-Barr virus (EBV) switches between latent and lytic phases in hosts that are important in developing related diseases. However, the underlying mechanism of how the viral latent-lytic switch is controlled and how EBV itself mediates this regulation remains largely unknown. This study identified the upregulated histone acetyl reader bromodomain-containing protein 7 (BRD7) during EBV latent infection. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL24676
4 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE202701

ID:: 200202701

PubMed Full text in PMC Similar studies

Select item 20003991319.

EBNA1 ChIP-seq and MNase-seq in EBV-positive MUTU cell lines

(Submitter supplied) Epstein-Barr Virus (EBV), which is associated with multiple human tumors, persists as a minichromosome in the nucleus of B-lymphocytes and induces malignancies through incompletely understood mechanisms. Here, we present a large-scale functional genomic analysis of EBV. Our experimentally generated nucleosome positioning maps and viral protein binding data were integrated with over 700 publicly available high-throughput sequencing data sets for human lymphoblastoid cell lines mapped to the EBV genome. more...

Organism:: human gammaherpesvirus 4

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL15906
6 Samples

Download data: WIG

Series

Accession:: GSE39913

ID:: 200039913

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015405220.

Epstein-Barr Virus episome physically interacts with active regions of the host genome in lymphoblastoid cells

(Submitter supplied) Epstein-Barr virus (EBV) episome is known to interact with the three-dimensional structure of human genome in infected cells. However, the exact locations of these interactions and their potential functional consequences remain unclear. Recently the high-resolution chromatin interaction capture (Hi-C) assays in lymphoblastoid cells have become available enabling us to precisely map the contacts between the EBV episome(s) and the human host genome. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL11154
2 Samples

Download data: BED

Series

Accession:: GSE154052

ID:: 200154052

PubMed Full text in PMC Similar studies SRA Run Selector

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