GEO DataSets

(Submitter supplied) Rationale: Obstructive sleep apnea (OSA) has been associated with a number of chronic disorders that may improve with effective therapy. However, the molecular pathways affected by continuous positive airway pressure (CPAP) treatment are largely unknown. We sought to assess the system-wide consequences of CPAP therapy by transcriptionally profiling peripheral blood leukocytes (PBLs). Methods: Subjects diagnosed with severe OSA were treated with CPAP, and whole-genome expression measurement of PBLs was performed at baseline and following therapy. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS5358

Platform:

GPL6244

36 Samples

Download data: CEL

Analysis of peripheral blood leukocytes from patients with severe obstructive sleep apnea (OSA) before and after continuous positive airway pressure (CPAP) treatment. Results provide insight into the system-wide molecular response of OSA patients to CPAP therapy.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 18 individual, 2 protocol sets

Platform:

GPL6244

Series:

GSE49800

36 Samples

Download data: CEL

(Submitter supplied) Obstructive sleep apnea (OSA) has been linked to dysregulated metabolic states and treatment of sleep apnea may improve these conditions. Subcutaneous adipose tissue is a readily samplable fat depot that plays an important role in regulating metabolism. However, neither the pathophysiologic consequences of OSA nor the effects of continuous positive airway pressure (CPAP) in altering this compartment’s molecular pathways are understood. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL6244

66 Samples

Download data: CEL

(Submitter supplied) Therefore, we extended our investigation into OSA patients with long-term continuous positive airway pressure (CPAP) treatment, hypertension, or excessive daytime sleepiness (EDS) by analyzing whole-genome gene expression profiles of PBMC in three comparisons: (1) treatment-naïve moderate to very severe OSA patients versus subjects with primary snoring; (2) moderate to very severe OSA patients with hypertension or EDS versus those without hypertension or EDS, respectively; (3) treatment-naïve very severe OSA patients versus those receiving at least one year of adequate CPAP treatment.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL10904

48 Samples

Download data: TXT

(Submitter supplied) Rationale: Obstructive sleep apnea (OSA) has been associated with metabolic dysregulation and systemic inflammation. This may be due to pathophysiologic effects of OSA on visceral adipose tissue. We sought to assess the transcriptional consequences of OSA on adipocytes by utilizing pathway-focused analyses. Methods: Patients scheduled to undergo ventral hernia repair surgery were recruited to wear a portable home sleep monitor for two nights prior to surgery. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4857

Platform:

GPL6244

18 Samples

Download data: CEL

Analysis of visceral fat samples from individuals with obstructive sleep apnea (OSA). OSA is associated with metabolic dysregulation and systemic inflammation. Results provide insight into the effect of OSA on visceral fat at the molecular level.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state sets

Platform:

GPL6244

Series:

GSE38792

18 Samples

Download data: CEL

(Submitter supplied) Sleep Disordered Breathing (SDB) is associated with a wide range of physiological changes, likely due in part to the influence of hypoxemia during sleep on gene expression. We studied gene expression in peripheral blood mononuclear cells in association with three measures of SDB: the Apnea Hypopnea Index (AHI); average oxyhemoglobin saturation (avgO2) during sleep; and minimum oxyhemoglobin saturation (minO2) during sleep. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL17244

30 Samples

Download data: CEL

(Submitter supplied) Obstructive sleep apnea (OSA) is common during pregnancy and is associated with adverse perinatal consequences, but it is not known whether it can also modulate fetal development processes. To understand the effects of OSA-affected mothers on fetus we analyzed the expression profile of hUCB cells under OSA conditions.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL23126

10 Samples

Download data: CEL