GEO DataSets

(Submitter supplied) Placenta transcriptome from two species of Spalax. Associated with the article "Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax."

Organism:

Spalax carmeli; Nannospalax galili

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL17526 GPL20184

2 Samples

Download data: FASTA, TXT

(Submitter supplied) Deep sequencing of mRNA from Spalax galili and Rattus norvegicus

Organism:

Nannospalax galili; Rattus norvegicus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL14844 GPL17526

12 Samples

Download data: BEDGRAPH

(Submitter supplied) Spalax, an underground fossoral rodant is exposed to chronic hypoxic environments. Measurements of Spalax burrows indicated 7% oxygen and up to 15% CO2. In the laboratory Spalax can survive 3% oxygen up to 14 hours as compared to rats that survive less than 4 hours at these oxygen levels. we have proposed Spalax as a model species for the investigation of hypoxia tolerance. this research has implications for many biomedical phenomena involving ischemic disease, notably heart disease and cancer. more...

Organism:

Nannospalax galili; Rattus norvegicus

Type:

Expression profiling by array

Platforms:

GPL14746 GPL15478

28 Samples

Download data: GPR

(Submitter supplied) This study compares response to hypoxia in muscle between 2 hypoxia tolerant species of Spalax ehrenbergi, blind subterranean mole rat . The blind subterranean mole rat (Spalax ehrenbergi superspecies) is an excellent model of hypoxic tolerance, living underground and exposed to fluctuating O2 and CO2 levels. Unique structural and functional adaptations of the cardiovascular and respiratory systems allow survival at severely reduced oxygen tension. more...

Organism:

Mus musculus; Nannospalax ehrenbergi; Nannospalax galili; Nannospalax judaei

Type:

Expression profiling by array

Platform:

GPL3236

12 Samples

Download data

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Nannospalax ehrenbergi; Mus musculus

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL17021 GPL25363

39 Samples

Download data

(Submitter supplied) Background: Spalax, the blind mole rat, developed an extraordinary cancer resistance during 40 million years of evolution in a subterranean, hypoxic, thus DNA damaging, habitat. In 50 years of Spalax research, no spontaneous cancer development has been observed. The mechanisms underlying this resistance are still not clarified. We investigated the genetic difference between Spalax and mice that might enable the Spalax relative resistance to cancer development. more...

Organism:

Nannospalax ehrenbergi; Mus musculus

Type:

Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL25363 GPL17021

14 Samples

Download data: CSV

(Submitter supplied) Background: Spalax, the blind mole rat, developed an extraordinary cancer resistance during 40 million years of evolution in a subterranean, hypoxic, thus DNA damaging, habitat. In 50 years of Spalax research, no spontaneous cancer development has been observed. The mechanisms underlying this resistance are still not clarified. We investigated the genetic difference between Spalax and mice that might enable the Spalax relative resistance to cancer development. more...

Organism:

Mus musculus; Nannospalax ehrenbergi

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL25363 GPL17021

25 Samples

Download data: CSV

(Submitter supplied) Deep sequencing of mRNA from naked mole rat

Organism:

Heterocephalus glaber

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13793

13 Samples

Download data: BEDGRAPH

(Submitter supplied) Linking genomic variation to phenotypical traits remains a major challenge in evolutionary genetics. In this study, we use phylogenomic strategies to investigate a distinctive trait among mammals: the development of masculinizing ovotestes in female moles. By combining a chromosome-scale genome assembly of the Iberian mole, Talpa occidentalis, with transcriptomic, epigenetic, and chromatin interaction datasets, we identify rearrangements altering the regulatory landscape of genes with distinct gonadal expression patterns. more...

Organism:

Talpa occidentalis

Type:

Other

Platforms:

GPL25619 GPL25620

3 Samples

Download data: HIC

(Submitter supplied) Linking genomic variation to phenotypical traits remains a major challenge in evolutionary genetics. In this study, we use phylogenomic strategies to investigate a distinctive trait among mammals: the development of masculinizing ovotestes in female moles. By combining a chromosome-scale genome assembly of the Iberian mole, Talpa occidentalis, with transcriptomic, epigenetic, and chromatin interaction datasets, we identify rearrangements altering the regulatory landscape of genes with distinct gonadal expression patterns. more...

Organism:

Talpa occidentalis; Mus musculus

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platforms:

GPL25619 GPL17021 GPL25620

70 Samples

Download data: BEDGRAPH, BW, HIC

(Submitter supplied) Linking genomic variation to phenotypical traits remains a major challenge in evolutionary genetics. In this study, we use phylogenomic strategies to investigate a distinctive trait among mammals: the development of masculinizing ovotestes in female moles. By combining a chromosome-scale genome assembly of the Iberian mole, Talpa occidentalis, with transcriptomic, epigenetic, and chromatin interaction datasets, we identify rearrangements altering the regulatory landscape of genes with distinct gonadal expression patterns. more...

Organism:

Talpa occidentalis

Type:

Other

Platforms:

GPL25619 GPL25620

2 Samples

Download data: BEDGRAPH, FA, GFF

(Submitter supplied) Linking genomic variation to phenotypical traits remains a major challenge in evolutionary genetics. In this study, we use phylogenomic strategies to investigate a distinctive trait among mammals: the development of masculinizing ovotestes in female moles. By combining a chromosome-scale genome assembly of the Iberian mole, Talpa occidentalis, with transcriptomic, epigenetic, and chromatin interaction datasets, we identify rearrangements altering the regulatory landscape of genes with distinct gonadal expression patterns. more...

Organism:

Talpa occidentalis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL25619

6 Samples

Download data: BED, BW, FA, GFF

(Submitter supplied) Linking genomic variation to phenotypical traits remains a major challenge in evolutionary genetics. In this study, we use phylogenomic strategies to investigate a distinctive trait among mammals: the development of masculinizing ovotestes in female moles. By combining a chromosome-scale genome assembly of the Iberian mole, Talpa occidentalis, with transcriptomic, epigenetic, and chromatin interaction datasets, we identify rearrangements altering the regulatory landscape of genes with distinct gonadal expression patterns. more...

Organism:

Talpa occidentalis

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL25619

24 Samples

Download data: BED, BW, FA, GFF

(Submitter supplied) Linking genomic variation to phenotypical traits remains a major challenge in evolutionary genetics. In this study, we use phylogenomic strategies to investigate a distinctive trait among mammals: the development of masculinizing ovotestes in female moles. By combining a chromosome-scale genome assembly of the Iberian mole, Talpa occidentalis, with transcriptomic, epigenetic, and chromatin interaction datasets, we identify rearrangements altering the regulatory landscape of genes with distinct gonadal expression patterns. more...

Organism:

Mus musculus; Talpa occidentalis

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL25619 GPL17021

35 Samples

Download data: BW, FA, GFF