Similar studies for GEO DataSets (Select 200071179) - GEO DataSets

Select item 2000711791.

The splicing regulator PTBP1 controls the activity of the transcription factor Pbx1 during neuronal differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL13112
30 Samples

Download data: BED, TXT

Series

Accession:: GSE71179

ID:: 200071179

PubMed Full text in PMC Similar studies

Select item 2000711782.

Ptpb1 iCLIP in 46C mESCs and mNPCs

(Submitter supplied) PTBP1 and PTBP2 control alternative splicing programs during neuronal development, but the cellular functions of most PTBP1/2-regulated isoforms remain unknown. We show that PTBP1 guides developmental gene expression by regulating the transcription factor Pbx1. We identify exons that are differentially spliced when mouse embryonic stem cells (ESCs) differentiate into neuronal progenitor cells (NPCs) and neurons, and transition from PTBP1 to PTBP2 expression. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL13112
2 Samples

Download data: BED

Series

Accession:: GSE71178

ID:: 200071178

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000710793.

Splicing analyses of mESCs, mNPCs, and mMNs

(Submitter supplied) PTBP1 and PTBP2 control alternative splicing programs during neuronal development, but the cellular functions of most PTBP1/2-regulated isoforms remain unknown. We show that PTBP1 guides developmental gene expression by regulating the transcription factor Pbx1. We identify exons that are differentially spliced when mouse embryonic stem cells (ESCs) differentiate into neuronal progenitor cells (NPCs) and neurons, and transition from PTBP1 to PTBP2 expression. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL13112
3 Samples

Download data: TXT

Series

Accession:: GSE71079

ID:: 200071079

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000709854.

Splicing analyses of 46C mNPCs following PTBP depletion

(Submitter supplied) PTBP1 and PTBP2 control alternative splicing programs during neuronal development, but the cellular functions of most PTBP1/2-regulated isoforms remain unknown. We show that PTBP1 guides developmental gene expression by regulating the transcription factor Pbx1. We identify exons that are differentially spliced when mouse embryonic stem cells (ESCs) differentiate into neuronal progenitor cells (NPCs) and neurons, and transition from PTBP1 to PTBP2 expression. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL13112
8 Samples

Download data: TXT

Series

Accession:: GSE70985

ID:: 200070985

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000708835.

Gene expression analyses of HB9-GFP D2 mMN cultures following Pbx1 exon 7 inclusion

(Submitter supplied) PTBP1 and PTBP2 control alternative splicing programs during neuronal development, but the cellular functions of most PTBP1/2-regulated isoforms remain unknown. We show that PTBP1 guides developmental gene expression by regulating the transcription factor Pbx1. We identify exons that are differentially spliced when mouse embryonic stem cells (ESCs) differentiate into neuronal progenitor cells (NPCs) and neurons, and transition from PTBP1 to PTBP2 expression. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE70883

ID:: 200070883

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2002413796.

Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of embryonic stem cell maintenance and neuronal differentiation [ChIP-seq]

(Submitter supplied) Maintenance of embryonic stem cells (ESCs) and their differentiation to neuronal lineages requires complex genetic regulation of transcription, splicing, and translation, but the interconnections of these processes is not well understood. We found that the splicing regulator polypyrimidine tract binding protein 1 (PTBP1) alters the neuronal transcriptional program. Transcripts for DPF2, a subunit of the BRG1/BRM-associated factor (BAF) chromatin remodeling complex, contain an additional exon (exon 7) in brain. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21493
20 Samples

Download data: BW

Series

Accession:: GSE241379

ID:: 200241379

PubMed Similar studies

Select item 2002413787.

Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of embryonic stem cell maintenance and neuronal differentiation.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL24247 GPL21493
36 Samples

Download data

Series

Accession:: GSE241378

ID:: 200241378

PubMed Similar studies

Select item 2002413778.

Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of embryonic stem cell maintenance and neuronal differentiation [RNA-seq]

(Submitter supplied) Maintenance of embryonic stem cells (ESCs) and their differentiation to neuronal lineages requires complex genetic regulation of transcription, splicing, and translation, but the interconnections of these processes is not well understood. We found that the splicing regulator polypyrimidine tract binding protein 1 (PTBP1) alters the neuronal transcriptional program. Transcripts for DPF2, a subunit of the BRG1/BRM-associated factor (BAF) chromatin remodeling complex, contain an additional exon (exon 7) in brain. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
18 Samples

Download data: TXT

Series

Accession:: GSE241377

ID:: 200241377

PubMed Similar studies

Select item 2002413769.

Alternative splicing of a chromatin modifier alters the transcriptional regulatory programs of embryonic stem cell maintenance and neuronal differentiation[ATAC-seq]

(Submitter supplied) Maintenance of embryonic stem cells (ESCs) and their differentiation to neuronal lineages requires complex genetic regulation of transcription, splicing, and translation, but the interconnections of these processes is not well understood. We found that the splicing regulator polypyrimidine tract binding protein 1 (PTBP1) alters the neuronal transcriptional program. Transcripts for DPF2, a subunit of the BRG1/BRM-associated factor (BAF) chromatin remodeling complex, contain an additional exon (exon 7) in brain. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL21493
18 Samples

Download data: BW

Series

Accession:: GSE241376

ID:: 200241376

PubMed Similar studies

Select item 20008516510.

Identification of PTBPs RNA binding sites in mouse brain

(Submitter supplied) PTBP1 and PTBP2 are RNA-binding proteins that control RNA processings, including alternative pre-mRNA splicing. The sequential down-regulation of the two proteins is necessary for neuronal maturation. However, their binding substrates in neural tissues have not been examined.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
6 Samples

Download data: GFF

Series

Accession:: GSE85165

ID:: 200085165

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20008480311.

Transcriptome of the mouse neocortices

(Submitter supplied) Derive alternative splicing regulatory networks of PTBP1 and PTBP2

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
7 Samples

Download data: XLSX

Series

Accession:: GSE84803

ID:: 200084803

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20000849812.

The MicroRNA miR-124 Promotes Neuronal Differentiation by Triggering Brain-Specific Alternative Pre-mRNA Splicing

(Submitter supplied) Both microRNAs and alternative pre-mRNA splicing have been implicated in the development of the nervous system (NS), but functional interactions between these two pathways are poorly understood. We demonstrate that the neuron-specific microRNA miR-124a directly targets PTBP1/PTB/hnRNPI mRNA, which encodes a global repressor of alternative pre-mRNA splicing in non-neuronal cells. Among the targets of PTBP1 is a critical cassette exon in the pre-mRNA of PTBP2/nPTB/brPTB, an NS-enriched PTBP1 homolog. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS2846
Platform:: GPL1261
6 Samples

Download data: CEL

Series

Accession:: GSE8498

ID:: 200008498

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 284613.

MicroRNA miR-124 expression effect on neuronal cell line

Analysis of neuroblastoma CAD cells expressing neuron-specific microRNA miR-124. MicroRNAs have been implicated in the development of the nervous system (NS). Results provide insight into the function of miR-124 in neuronal cells.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 protocol sets

Platform:: GPL1261
Series:: GSE8498
6 Samples

Download data: CEL

DataSet

Accession:: GDS2846

ID:: 2846

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20004756714.

Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Other; Expression profiling by array

Platforms:: GPL11002 GPL6193 GPL8940
22 Samples

Download data: CEL

Series

Accession:: GSE47567

ID:: 200047567

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004756615.

Wild type vs. Ptbp2 KO mouse embryonic cortex RNA

(Submitter supplied) To assess the requirement of Ptbp2 for alternative processing of RNA in mouse brain

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL8940
6 Samples

Download data: CEL

Series

Accession:: GSE47566

ID:: 200047566

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004756516.

Wild type vs. Ptbp2 KO mouse E18.5 cortex RNA

(Submitter supplied) To assess the requirement of Ptbp2 for alternative mRNA expression in mouse brain

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6193
8 Samples

Download data: CEL

Series

Accession:: GSE47565

ID:: 200047565

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20004756417.

Ptbp2 represses adult-specific splicing to regulate the generation of neuronal precursors in the embryonic brain [HITS-CLIP]

(Submitter supplied) Two polypyrimidine tract RNA-binding proteins (PTBs), one near-ubiquitously expressed (Ptbp1) and another highly tissue-restricted (Ptbp2), regulate RNA in interrelated but incompletely understood ways. Ptbp1, a splicing regulator, is replaced in the brain and differentiated neuronal cell lines by Ptbp2. To define the roles of Ptbp2 in the nervous system, we generated two independent Ptbp2-null strains, unexpectedly revealing that Ptbp2 is expressed in neuronal progenitors and is essential for postnatal survival. more...

Organism:: Mus musculus

Type:: Other

Platform:: GPL11002
8 Samples

Download data: BED, WIG

Series

Accession:: GSE47564

ID:: 200047564

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007619818.

Cell type-specific alternative splicing of cytoskeletal domains governs cell fate in the developing cerebral cortex

(Submitter supplied) Alternative splicing regulates over 90% of multiexon mammlian genes, but its role in specifying neural progenitor cell (NPC) fates has not been explored. Our analyses of purified mouse NPCs and neurons from developing cerebral cortices revealed hundreds of conserved and differentially spliced exons that add or remove key protein domains, especially in genes regulating the cytoskeleton.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
4 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE76198

ID:: 200076198

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006554219.

The PTBP1-associated long noncoding RNA Pnky regulates embryonic and postnatal neural stem cells

(Submitter supplied) While thousands of long noncoding RNAs (lncRNAs) have been identified, few lncRNAs that control neural stem cell (NSC) behavior are known. Here, we identify Pinky (Pnky) as a novel, neural-specific lncRNA that regulates neurogenesis from NSCs in the embryonic and postnatal brain. In postnatal NSCs, Pnky knockdown potentiates neuronal lineage commitment and expands the transit-amplifying cell population, increasing neuron production several-fold. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: DIFF, TXT

Series

Accession:: GSE65542

ID:: 200065542

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007983220.

Altered expression of genes in lncRNA-LBCS, hnRNPK and PTBP1 knockdown

(Submitter supplied) We identify a lncRNA which low expresses and regulates self-renewal of bladder cancer stem cell. So we named it lncRNA-LBCS (low expresses in bladder cancer stem cell). Further study finds that lncRNA-LBCS bind to hnRNPK and PTBP1. To investigate the genes regulated by these, we knockdown lncRNA-LBCS, hnRNPK and PTBP1 by siRNA, respectively, and perform high-throughput sequence. So we identify a series of genes regulated by lncRNA-LBCS, hnRNPK and PTBP1, respectively.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
4 Samples

Download data: TXT

Series

Accession:: GSE79832

ID:: 200079832

PubMed Full text in PMC Similar studies SRA Run Selector

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