GEO DataSets

(Submitter supplied) In this study, we further verified the role of LIF by looking at gene expressions in morula stage embryos through DNA microarray. Our results showed that LIF knockdown affected 373 gene expressions, and after LIF supplementation we found that the epidermal growth factor (EGF) is most affected by LIF expression. In order to observe the correlation between LIF and EGF, the LIF knockdown embryos were supplemented with various growth factors including LIF, EGF, GM-CSF, TGF, and IGF II. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL872

2 Samples

Download data: TXT

(Submitter supplied) Bcl3 is expressed in mESCs. ChIP-seq was used to identify its binding pattern and target genes.

Organism:

Mus musculus

Type:

Genome binding/occupancy profiling by high throughput sequencing

Platform:

GPL9185

2 Samples

Download data: XLSX

(Submitter supplied) Leukemia Inhibitory Factor (LIF) plays an essential role in the maintenance of pluripotency of mouse embryonic stem cells (mESCs). LIF withdrawal induces mESC differentiation. To define noval pluripotent factors downstream of LIF signaling, cDNA microarray was used and seveal well-known pluripotent genes were found to respond to LIF withdrawal, including Klf4, Esrrb, Tbx3, and Prdm14.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL1261

4 Samples

Download data: CEL

(Submitter supplied) To characterize the differential effects of LIF in BAE vs BCE cells, genes induced/suppressed by LIF were analyzed by RNA-seq following incubation with LIF. Remarkably, LIF treatment led to distinct gene expression patterns in these two cell types.

Organism:

Bos taurus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23295

8 Samples

Download data: TXT

(Submitter supplied) Leukemia inhibitory factor (LIF) is amongst the IL-6 family cytokines expressed in the lungs during pneumonia. However, the function of endogenous LIF during pneumonia has never been explored. The purpose of this study was to determine the transcriptional response to pneumonia in the lungs and whether or how this response is influenced by LIF. Mice received intratracheal instillations of vehicle (PBS) or Escherichia coli (10^6 CFU). more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4583

Platform:

GPL11078

9 Samples

Download data: CEL

Analysis of lung from C57BL/6 animals during E. coli pneumonia in the presence of neutralizing anti-leukemia inhibitory factor (LIF) antibody. Anti-LIF exacerbates lung injury. Results provide insight into molecular mechanisms underlying the pathophysiology of pneumonia.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 infection, 2 protocol sets

Platform:

GPL11078

Series:

GSE34901

9 Samples

Download data: CEL

(Submitter supplied) The beta (β) cell mass formed during embryogenesis is amplified by cell replication that occurs primarily during fetal and early postnatal development. Thereafter, β cells become functionally mature and their mass is maintained by a very low rate of replication. For those few β cells that replicate in adult life, it is not known how replication is initiated, uncoupled from β cell function nor whether this occurs in a specialized subset of β cells. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

14 Samples

Download data: H5, TXT