GEO DataSets

(Submitter supplied) Anthelmintic resistance is a major problem in the global fight against parasitic nematodes., Most previous studies have focused on the analysis of potential candidate genes that may have a role in resistance. Here we take a novel approach in the important parasite, Haemonchus contortus, by investigating changes in microRNA expression between resistant and susceptible parasites. The resistant worms included two geographically distinct strains and two lines generated by multiple rounds of backcrossing between susceptible and resistant parents, with ivermectin selection. more...

Organism:

Haemonchus contortus

Type:

Non-coding RNA profiling by array

Platform:

GPL21648

27 Samples

Download data: XLS

(Submitter supplied) Examined expression of microRNAs in different life-cycle stages and gut tissue of the pathogenic nematode Haemonchus contortus and identified differentially expressed miRNAs. Custom array contained probes to 609 Haemonchus contortus miRNA sequence (all mature and start miRNAs identified by Winter et al., 2012, BMC Genomics13:4; DOI: 10.1186/1471-2164-13-4) and all C. elegans sequences in miRBase release 16

Organism:

Caenorhabditis elegans; Haemonchus contortus

Type:

Non-coding RNA profiling by array

Platform:

GPL23788

17 Samples

Download data: TXT

(Submitter supplied) Illumina sequencing of small RNAs from Brugia pahangi and Haemonchus contortus

Organism:

Brugia pahangi; Haemonchus contortus

Type:

Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL15031 GPL15032

4 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Heligmosomoides polygyrus; Litomosoides sigmodontis

Type:

Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL18433 GPL18432 GPL19032

12 Samples

Download data: TXT

(Submitter supplied) In mammalian systems, extracellular small RNAs can operate in a paracrine manner to communicate information between cells, relying on transport within vesicles. “Foreign” small RNAs derived from bacteria, plants and parasites have also been detected in mammalian body fluids, sparking interest in whether these could mediate inter-species communication. However, there is no mechanistic framework for RNA-mediated interspecies communication and the active movement of RNA via vesicles has not been shown outside of mammals. more...

Organism:

Litomosoides sigmodontis

Type:

Non-coding RNA profiling by high throughput sequencing

Platform:

GPL19032

2 Samples

Download data: TXT

(Submitter supplied) In mammalian systems, extracellular small RNAs can operate in a paracrine manner to communicate information between cells, relying on transport within vesicles. “Foreign” small RNAs derived from bacteria, plants and parasites have also been detected in mammalian body fluids, sparking interest in whether these could mediate inter-species communication. However, there is no mechanistic framework for RNA-mediated interspecies communication and the active movement of RNA via vesicles has not been shown outside of mammals. more...

Organism:

Heligmosomoides polygyrus

Type:

Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL18432 GPL18433

10 Samples

Download data: TXT

(Submitter supplied) We show that a gastrointestinal nematode that infects mice, Heligmosomoides polygyrus, secretes vesicles packaged with specific microRNAs (miRNAs) and Y RNAs as well as a nematode-specific Argonaute protein. The vesicles are of intestinal origin and are enriched for homologs of mammalian proteins found in exosomes, including heat shock proteins, tetraspanins and an ESCORT protein. The nematode-derived vesicles are internalized by mouse intestinal epithelial cells and mediate changes in expression of host genes involved in inflammation and immunity, including the receptor for the alarmin IL33 as well as a key regulator of MAPK signaling, DUSP1.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6887

11 Samples

Download data: TXT