Similar studies for GEO DataSets (Select 200083891) - GEO DataSets

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Items: 2

Select item 2000838911.

Tunable regulation of CREB DNA binding activity couples genotoxic stress response and metabolism

(Submitter supplied) In this study we show that, in embryonic fibroblasts from mice on a high fat diet and treated with Forskolin, ionizing radiation exposure or both, phosphorylation of CREB-binding protein (CREB) by ATM (ataxia-telangiectasia-mutated) and casein kinases 1 and 2 (CK1 and CK2) on a cluster of five phosphorylation sites (the ATM/CK cluster) within the unstructured kinase-inducible domain (KID) provides an additional level of regulation through dynamic modulation of CREB DNA binding activity. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
48 Samples

Download data: TXT

Series

Accession:: GSE83891

ID:: 200083891

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000020602.

Characterize CREB target genes in different tissue types

(Submitter supplied) The CREB family of transcription factors stimulates cellular gene expression following phosphorylation at a conserved serine (Ser133 in CREB1) in response to cAMP and other extracellular signals. In order to characterize CREB target genes in various tissues, we give a cAMP agonist, forskolin (FSK), to cell lines or primary cultures and monitor the gene expression. To eliminate CREB-independent effects of FSK on cellular gene expression, we employed a dominant negative form of CREB called A-CREB, which dimerizes selectively with and blocks the DNA binding activity of CREB but not other bZIP family members. more...