Similar studies for GEO DataSets (Select 200089683) - GEO DataSets

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Items: 20

Select item 2000896831.

Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells [rnaseq]

(Submitter supplied) To follow the changes in the transcriptional programs accompanying the specification, maintenance and differentiation of the adult ISCs we sequenced whole transcriptomes of embryonic intestinal epithelium progenitors (at E12.5 and E14.5), adult ISCs and their differentiated progenies, the majority of which are absorptive enterocytes. EpCAM positive embryonic gut epithelium was isolated from dissected small intestines using fluorescence activated cell sorting (FACS). more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TSV

Series

Accession:: GSE89683

ID:: 200089683

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000896842.

Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platform:: GPL17021
74 Samples

Download data: TSV

Series

Accession:: GSE89684

ID:: 200089684

PubMed Full text in PMC Similar studies

Select item 2000896823.

Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells [mbd]

(Submitter supplied) We assessed whether changes in DNA methylation were associated with the regulation of ISC signature genes. Methylated regions of DNA from whole genome were isolated using Methyl Binding Domain pull-down followed by sequencing (MBD-seq). The size of DNA fragments was between 120 to 170 bp, which provides a resolution at nucleosome level.

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: TSV

Series

Accession:: GSE89682

ID:: 200089682

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000896814.

Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells [k27m3]

(Submitter supplied) To determine chromatin changes associated with ISCs specification we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) using 2x105 FACS purified E12.5 or E14.5 embryonic intestinal epithelial cells, Lgr5+ adult ISCs and enterocytes.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TSV

Series

Accession:: GSE89681

ID:: 200089681

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000896805.

Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells [k27ac]

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
16 Samples

Download data: TSV

Series

Accession:: GSE89680

ID:: 200089680

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000896796.

Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells [k4m3]

(Submitter supplied) To determine chromatin changes associated with ISCs specification we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) using 2x10e5 FACS purified E12.5 or E14.5 embryonic intestinal epithelial cells, Lgr5+ adult ISCs and enterocytes.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
12 Samples

Download data: TSV

Series

Accession:: GSE89679

ID:: 200089679

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000896787.

Dynamic changes in chromatin states during specification and differentiation of adult intestinal stem cells [h2az]

(Submitter supplied) To determine chromatin changes associated with ISCs specification we performed chromatin immunoprecipitation followed by sequencing (ChIP-seq) using 2x10e5 FACS purified E12.5 or E14.5 embryonic intestinal epithelial cells, Lgr5+ adult ISCs and enterocytes.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
14 Samples

Download data: TSV

Series

Accession:: GSE89678

ID:: 200089678

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001241858.

Co-repressors Mtg8 and Mtg16 regulate niche exit and early fate decision of crypt stem cells (RNA-seq)

(Submitter supplied) In this experiment, the differential gene expression was examined in intestinal epithelial cells of Mtg16 null mice compared to wild type.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
6 Samples

Download data: TSV

Series

Accession:: GSE124185

ID:: 200124185

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000602049.

Quantitative Dynamics of Chromatin Remodeling during Germ Cell Specification from Mouse Embryonic Stem Cells

(Submitter supplied) Germ cell specification is accompanied by epigenetic remodeling, the scale and specificity of which are unclear. Here, we quantitatively delineate chromatin dynamics during induction of mouse embryonic stem cells (ESCs) to epiblast-like cells (EpiLCs) and from there into primordial germ cell-like cells (PGCLCs), revealing large-scale reorganization of chromatin signatures including H3K27me3 and H3K9me2 patterns. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL15907
54 Samples

Download data: BED, TDF

Series

Accession:: GSE60204

ID:: 200060204

PubMed Similar studies SRA Run Selector

Select item 20006001810.

Quantitative Dynamics of Chromatin-state Reprogramming for the Mouse Germ-Cell Specification Pathway In Vitro

(Submitter supplied) We re-analyzed gene expression in the primordial germ cell (PGC) specification pathway in vitro, by using previously deposited microarray data. The germ cell lineage produces either spermatozoa or oocytes and, by their fusion, creates zygotes with full developmental potential, thereby perpetuating and diversifying organisms' genetic as well as epigenetic information across generations. In mice, PGCs are specified in the most posterior part of epiblast (monolayer epitherium-like cells, from which the whole embryonic part of conceptus will be derived) around embryonic day (E) 6.25 by a cytokine BMP4. more...

Organism:: Mus musculus

Type:: Expression profiling by array; Third-party reanalysis

Platform:: GPL1261
6 Samples

Download data: CEL, TXT

Series

Accession:: GSE60018

ID:: 200060018

PubMed Similar studies

Select item 20007607411.

Distinct Chromatin States Define a Program Of Mesenchymal Stem Cell Commitment To Osteogenesis

(Submitter supplied) Multipotent mesenchymal stromal cells (MSCs) from bone marrow are critical for regeneration and homeostasis of multiple tissues. As epigenetic mechanisms are a fundamental regulator of lineage specification and cell fate, we examined histone modification changes in MSCs at distinct stages osteogenic differentiation, including: proliferation, early commitment, matrix deposition, and mineralization. Temporal changes of multiple histone modifications along with several transcriptional regulators were assessed and correlated to gene expression, which revealed distinct epigenetic mechanisms that regulate transcriptional programs necessary for commitment and tissue-specific phenotype development. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL9250 GPL13112
80 Samples

Download data

Series

Accession:: GSE76074

ID:: 200076074

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016431712.

(Submitter supplied) Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful execution of lineage decisions remains largely unknown. Here, we address this question using genome-wide chromatin accessibility and transcriptome analysis as well as single cell RNA-seq to explore stem cell-intrinsic changes in the aging Drosophila intestine. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17275
8 Samples

Download data: BIGWIG, XLSX

Series

Accession:: GSE164317

ID:: 200164317

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20016340613.

Trx knockdown in intestinal stem cells (ISCs) of Drosophila melanogaster

(Submitter supplied) Male flies were crossed to virgins of genotype yw;esg-Gal4,UAS-GFP;tub-Gal80ts/Tm3,Sb. Progeny was collected and aged 3-4 days before shifting for 7 days to 29 degrees to induce RNAi expression. Guts were dissected for 2 biological replicates/condition, each containing 80-100 guts, dissociated and GFP-positive cells were FACS-sorted. RNA was isolated using the PicoPure RNA-isolation kit and libraries were generated. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13304
4 Samples

Download data: TSV

Series

Accession:: GSE163406

ID:: 200163406

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015779614.

Aging ISCs and Polycomb KD ISCs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL13304 GPL17275 GPL21306
61 Samples

Download data: BIGWIG, TSV

Series

Accession:: GSE157796

ID:: 200157796

PubMed Full text in PMC Similar studies

Select item 20015779415.

RNAseq of Aging Drosophila ISCs

(Submitter supplied) Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful execution of lineage decisions remains largely unknown. Here, we address this question using genome-wide chromatin accessibility and transcriptome analysis as well as single cell RNA-seq to explore stem cell intrinsic changes in the aging Drosophila intestine. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17275
16 Samples

Download data: TSV

Series

Accession:: GSE157794

ID:: 200157794

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015779316.

RNAseq of Polycomb KD ISCs

(Submitter supplied) Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful execution of lineage decisions remains largely unknown. Here, we address this question using genome-wide chromatin accessibility and transcriptome analysis as well as single cell RNA-seq to explore stem cell intrinsic changes in the aging Drosophila intestine. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17275
6 Samples

Download data: TSV

Series

Accession:: GSE157793

ID:: 200157793

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015777817.

ATACseq of Polycomb KD ISCs [NGS2975]

(Submitter supplied) Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful execution of lineage decisions remains largely unknown. Here, we address this question using genome-wide chromatin accessibility and transcriptome analysis as well as single cell RNA-seq to explore stem cell intrinsic changes in the aging Drosophila intestine. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17275
6 Samples

Download data: TSV

Series

Accession:: GSE157778

ID:: 200157778

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015777618.

ATACseq of Aging Drosophila ISCs [NGS2046]

(Submitter supplied) Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful execution of lineage decisions remains largely unknown. Here, we address this question using genome-wide chromatin accessibility and transcriptome analysis as well as single cell RNA-seq to explore stem cell intrinsic changes in the aging Drosophila intestine. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17275
16 Samples

Download data: TSV

Series

Accession:: GSE157776

ID:: 200157776

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20015777519.

scRNAseq of Aging Drosophila ISCs [NGS1910]

(Submitter supplied) Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and how age-related changes in somatic stem cells impact the faithful execution of lineage decisions remains largely unknown. Here, we address this question using genome-wide chromatin accessibility and transcriptome analysis as well as single cell RNA-seq to explore stem cell intrinsic changes in the aging Drosophila intestine. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21306
5 Samples

Download data: CSV, MTX, RDS, TSV

Series

Accession:: GSE157775

ID:: 200157775

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20006147520.

Transcription factor binding dynamics during human ES cell differentiation

(Submitter supplied) Pluripotent stem cells provide a powerful system to dissect the underlying molecular dynamics that regulate cell fate changes during mammalian development. Here we report the integrative analysis of genome wide binding data for 38 transcription factors with extensive epigenome and transcriptional data across the differentiation of human embryonic stem cells to the three germ layers. We describe core regulatory dynamics and show the lineage specific behavior of selected factors. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL11154
204 Samples

Download data: BIGBED, BW, TXT

Series

Accession:: GSE61475

ID:: 200061475

PubMed Full text in PMC Similar studies SRA Run Selector

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