GEO DataSets

(Submitter supplied) Copy number alteration in out-growing mouse tumor cells comparing that in the original tumor cells that was primarily inoculated into the indicated mice. Goal is to determine the effects of IFN-gamma producing tumor-specific CTL on targeted tumor cell gene expression.

Organism:

Mus musculus

Type:

Genome variation profiling by genome tiling array

Platform:

GPL10449

10 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Genome variation profiling by genome tiling array

Platform:

GPL10449

63 Samples

Download data: TXT

(Submitter supplied) Copy number alteration in out-growing mouse tumor cells comparing that in the original tumor cells that was primarily inoculated into the indicated mice. Goal is to determine the effects of IFN-gamma producing tumor-specific CTL on targeted tumor cell gene expression.

Organism:

Mus musculus

Type:

Genome variation profiling by genome tiling array

Platform:

GPL10449

6 Samples

Download data: TXT

(Submitter supplied) Copy number alteration in out-growing mouse tumor cells comparing that in the original tumor cells that was primarily inoculated into the indicated mice. Goal is to determine the effects of IFN-gamma producing tumor-specific CTL on targeted tumor cell gene expression.

Organism:

Mus musculus

Type:

Genome variation profiling by genome tiling array

Platform:

GPL10449

10 Samples

Download data: TXT

(Submitter supplied) Copy number alteration in out-growing mouse tumor cells comparing that in the original tumor cells that was primarily inoculated into the indicated mice. Goal is to determine the effects of IFN-gamma producing tumor-specific CTL on targeted tumor cell gene expression.

Organism:

Mus musculus

Type:

Genome variation profiling by genome tiling array

Platform:

GPL10449

8 Samples

Download data: TXT

(Submitter supplied) Copy number alteration in out-growing mouse tumor cells comparing that in the original tumor cells that was primarily inoculated into the indicated mice. Goal is to determine the effects of IFN-gamma producing tumor-specific CTL on targeted tumor cell gene expression.

Organism:

Mus musculus

Type:

Genome variation profiling by genome tiling array

Platform:

GPL10449

9 Samples

Download data: TXT

(Submitter supplied) Copy number alteration in out-growing mouse tumor cells comparing that in the original tumor cells that was primarily inoculated into the indicated mice. Goal is to determine the effects of IFN-gamma producing tumor-specific CTL on targeted tumor cell gene expression.

Organism:

Mus musculus

Type:

Genome variation profiling by genome tiling array

Platform:

GPL10449

10 Samples

Download data: TXT

(Submitter supplied) Copy number alteration in out-growing mouse tumor cells comparing that in the original tumor cells that was primarily inoculated into the indicated mice. Goal is to determine the effects of IFN-gamma producing tumor-specific CTL on targeted tumor cell gene expression.

Organism:

Mus musculus

Type:

Genome variation profiling by genome tiling array

Platform:

GPL10449

10 Samples

Download data: TXT

(Submitter supplied) PD-L1 suppresses host immunity and promotes tumor growth. We investigated how IFN-γ regulates PD-L1 in the ovarian cancer microenvironment. In clinical samples, the number of stromal CTLs in peritoneally disseminated tumors was correlated with PD-L1 expression on the tumor cells, and the lymphocyte number was significantly related to the IFN-γ signature score. In mouse models, PD-L1 was induced in peritoneal disseminated tumors, where lymphocytes were prominent, but not in subcutaneous tumors. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

12 Samples

Download data: CEL

(Submitter supplied) The source of IFN-γ in ovarian cancer microenvironment and its biological effect to the tumor cells is unclear. The immortalized human ovarian surface epithelial cell line, HOSE-E7/hTERT (HOSE) was treated with IFN-γ and expression microarray analysis was performed, and probes showing significantly higher values in IFN-γ-added group were termed “IFN-γ signature genes (295 probes)”. We then applied this signature to our ovarian cancer microarray data, which included 75 ovarian cancer clinical samples, by means of ss-GSEA. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

8 Samples

Download data: CEL

(Submitter supplied) The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood. To identify a phenotypically robust core set of genes and pathways that facilitate cancer cell-intrinsic evasion to cytotoxic T lymphocyte (CTL)-mediated killing, we performed genome-wide CRISPR screens across a panel of genetically diverse cancer models cultured in the presence of CTLs. more...

Organism:

Mus musculus

Type:

Other

Platform:

GPL17021

46 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Other

Platforms:

GPL17021 GPL19057 GPL24247

311 Samples

Download data: TXT

(Submitter supplied) The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood. To identify a phenotypically robust core set of genes and pathways that facilitate cancer cell-intrinsic evasion to cytotoxic T lymphocyte (CTL)-mediated killing, we performed genome-wide CRISPR screens across a panel of genetically diverse cancer models cultured in the presence of CTLs. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

78 Samples

Download data: TXT

(Submitter supplied) The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood. To identify a phenotypically robust core set of genes and pathways that facilitate cancer cell-intrinsic evasion to cytotoxic T lymphocyte (CTL)-mediated killing, we performed genome-wide CRISPR screens across a panel of genetically diverse cancer models cultured in the presence of CTLs. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL19057 GPL24247

12 Samples

Download data: TXT

(Submitter supplied) The genetic circuits that allow cancer cells to evade destruction by the host immune system remain poorly understood. To identify a phenotypically robust core set of genes and pathways that facilitate cancer cell-intrinsic evasion to cytotoxic T lymphocyte (CTL)-mediated killing, we performed genome-wide CRISPR screens across a panel of genetically diverse cancer models cultured in the presence of CTLs. more...

Organism:

Mus musculus

Type:

Other

Platforms:

GPL17021 GPL19057

175 Samples

Download data: TXT

(Submitter supplied) miR-155 has recently emerged as an important promoter of antitumor immunity through its functions in T lymphocytes. However, the impact of T cell expressed miR-155 on immune cell dynamics in solid tumors remains unclear. In the present study, we used single-cell RNA-sequencing to define the CD45+ immune cell populations within B16F10 murine melanoma tumors growing in either wild-type (WT) or miR-155 T cell conditional knockout (TCKO) mice at different timepoints. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

4 Samples

Download data: MTX, TSV

(Submitter supplied) Purpose: Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but very few of them have been identified. Therefore, the goal of this study was to develop a novel approach, combining RNA-Sequencing and mass spectrometry, to enlarge the landscape of actionable TSAs in seven human primary samples, namely 4 B-ALL and 3 lung tumor biopsies.  Methods: We performed RNA-Sequencing on each primary tumor sample (unreplicated) with the Illumina HiSeq200. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL18573

6 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL19057 GPL11154 GPL13112

15 Samples

Download data: TSV

(Submitter supplied) Purpose: Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but very few of them have been identified. Therefore, the goal of this study was to develop a novel approach, combining RNA-Sequencing and mass spectrometry, to enlarge the landscape of actionable TSAs in seven human primary samples, namely 4 B-ALL and 3 lung tumor biopsies. Methods: We performed RNA-Sequencing on each primary tumor sample (unreplicated) with the Illumina HiSeq2000. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL11154

7 Samples

Download data: TSV

(Submitter supplied) Purpose: Tumor-specific antigens (TSAs) represent ideal targets for cancer immunotherapy, but very few of them have been identified. Therefore, the goal of this study was to develop a novel approach, combining RNA-Sequencing and mass spectrometry, to enlarge the landscape of actionable TSAs in two murine cell lines, namely EL4 and CT26 cells. Methods: We performed RNA-Sequencing on both tumor cell lines (unreplicated) as well as on the syngeneic mature medullary thymic epithelial cells (mTEChi, in triplicate), using either the Illumina HiSeq200 or the Illumina NextSeq 500. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:

GPL13112 GPL19057

8 Samples

Download data: TSV