Similar studies for GEO DataSets (Select 200092778) - GEO DataSets

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Items: 15

Select item 2000927781.

Niche targeting enhances endogenous healthy hematopoiesis in acute myeloid leukemia

(Submitter supplied) Global gene expression comparison between mesenchymal stem cells (MSCs) purified from the BM of AML patients versus healthy donors.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
12 Samples

Download data: CEL

Series

Accession:: GSE92778

ID:: 200092778

Select item 2000376422.

Prognostic gene signature for AML

(Submitter supplied) Acute myeloid leukemia (AML) is a heterogeneous disease in respect of molecular aberrations and prognosis. We used gene expression profiling of 562 patients treated in the German AMLCG 1999 trial to develop a gene signature that predicts survival in AML.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL96 GPL570 GPL97
984 Samples

Download data: CEL, TXT

Series

Accession:: GSE37642

ID:: 200037642

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000734963.

Gene expression analysis of primitive erythroid progenitors from 5-FU-treated WT and ESAM-KO mice.

(Submitter supplied) To determine the molecular mechanisms involved in the compromised erythropoiesis of ESAM-KO mice, Lin- FCgRII/III-/Lo CD41Lo c-Kit+ Sca1- endoglin+ CD150+ cells, which contain mostly BFU-E and CFU-E, were sorted from 5-FU-treated WT and ESAM-KO mice, and were subjected to microarray analyses.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL13912
2 Samples

Download data: TXT

Series

Accession:: GSE73496

ID:: 200073496

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002132104.

Transcriptomics of AML core bone marrow biopsies reveals distinct therapy response-specific osteo-mesenchymal profiles by RNA-seq and microarray analysis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL20301 GPL23126
44 Samples

Download data: CEL, TXT

Series

Accession:: GSE213210

ID:: 200213210

Select item 2002130565.

Transcriptomics of AML core bone marrow biopsies reveals distinct therapy response-specific osteo-mesenchymal profiles [microarray]

(Submitter supplied) While the bone marrow (BM) microenvironment is significantly remodeled in acute myeloid leukemia (AML), our understanding of chemotherapy-induced changes within the BM stroma and their involvement in disease recurrence remains limited. Molecular insight into AML-specific alterations in the microenvironment has been historically limited by the analysis of liquid marrow aspirates rather than core biopsies that contain solid-phase BM stroma with non-hematopoietic cells supporting hematopoiesis. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL23126
22 Samples

Download data: CEL

Series

Accession:: GSE213056

ID:: 200213056

Select item 2002126156.

Transcriptomics of AML core bone marrow biopsies reveals distinct therapy response-specific osteo-mesenchymal profiles

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
22 Samples

Download data: TXT

Series

Accession:: GSE212615

ID:: 200212615

PubMed Similar studies

Select item 2000262947.

Functional abnormalities and changes in gene expression in fibroblasts and macrophages from the bone marrow of patients with acute myeloid leukemia

(Submitter supplied) In leukemias and other malignancies of the bone marrow, little is known about the fate of fibroblasts and resident macrophages after normal hematopoietic cells are replaced by neoplastic cells. In the present investigation we used two-stage long-term bone marrow cultures to detect functional stromal cell abnormalities in acute myeloid leukemia, myelodysplastic syndromes and multiple myeloma. While fibroblasts from multiple myeloma and macrophages from multiple myeloma and myelodysplastic syndromes were functionally indistinguishable from the respective cell types from normal bone marrow, fibroblasts from patients with acute myeloid leukemia or myelodysplastic syndromes possessed a significantly lower ability to support hematopoiesis originating from co-cultured normal CD34-positive cells than fibroblasts from healthy marrow. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL571
16 Samples

Download data: CEL, CHP

Series

Accession:: GSE26294

ID:: 200026294

Select item 2002275848.

Glucose partitioning in the bone marrow micro-environment in acute myeloid leukaemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL21273
11 Samples

Download data: MTX, TSV

Series

Accession:: GSE227584

ID:: 200227584

PubMed Similar studies

Select item 2002275839.

Glucose partitioning in the bone marrow micro-environment in acute myeloid leukaemia [single-cell RNA-seq]

(Submitter supplied) To identify the metabolic transcriptome landscape within leukaemic cells we performed scRNA-Seq on the sorted leukaemia cells (GFP+) cells from MLL-AF9 mice.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21273
1 Sample

Download data: MTX, TSV

Series

Accession:: GSE227583

ID:: 200227583

PubMed Similar studies

Select item 20022758110.

Glucose partitioning in the bone marrow micro-environment in acute myeloid leukaemia [bulk RNA-seq]

(Submitter supplied) We used a positron emission tomography (PET) tracer 18F fluorodeoxyglucose ([18F]-FDG) and transcriptomic analysis to detect glucose uptake by cells in the bone marrow micro-environment with an MLL-AF9-induced mouse model. Leukaemic cells had the greatest glucose uptake. To determine whether glucose uptake is driven by intrinsic demand, we applied RNA-seq of sorted leukaemia cells (GFP+) and bone marrow micro-environment myeloid cells (GFP-CD11b+) from the MLL-AF9 transduced mouse model.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
10 Samples

Download data: TXT

Series

Accession:: GSE227581

ID:: 200227581

PubMed Similar studies

Select item 20019054211.

Germline ERCC6L2 mutations lead to impaired erythropoiesis and reshaping of the bone marrow niche

(Submitter supplied) Despite the inclusion of inherited myeloid malignancies as a separate entity in the WHO Classification, our understanding of the etiology of familial leukemia remains limited. ERCC6L2-deficiency is a rare, life-threatening inherited condition that gives rise to bone marrow failure (BMF), myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) resulting from germline mutations in DNA repair factor ERCC6L2. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
30 Samples

Download data: TXT

Series

Accession:: GSE190542

ID:: 200190542

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20022173812.

Comparison of gene expression profile between primary and bone metastasized cancers

(Submitter supplied) Bone metastasis occurs frequently in cancer patients. Conventional therapies have limited therapeutic outcomes, and thus, exploring the mechanisms of cancer progression in the bone metastasis is important to develop new effective therapies. In the bone microenvironment, adipocytes are the major stromal cells that interact with cancer cells during the bone metastasis. However, the comprehensive functions of bone marrow adipocytes in cancer progression are not yet fully understood. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data: XLSX

Series

Accession:: GSE221738

ID:: 200221738

PubMed Full text in PMC Similar studies

Select item 20015180213.

Adipocytes disrupt the translational programme of Acute Lymphoblastic Leukaemia to favour tumour survival and persistence

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
12 Samples

Download data

Series

Accession:: GSE151802

ID:: 200151802

PubMed Full text in PMC Similar studies

Select item 20015180114.

Adipocytes disrupt the translational programme of Acute Lymphoblastic Leukaemia to favour tumour survival and persistence [BM-MSC]

(Submitter supplied) Reprogramming of bone marrow microenvironments (BMMs) is a key process by which ALL cells gain resilience however the specific adaptations that facilitate primary disease and ALL survival after induction chemotherapy remain unclear. Using temporal analysis of clinical biopsies we identify that BM adipocytes are profoundly remodelled during ALL pathogenesis and treatment transitioning from cellular depletion within the primary leukaemia niche to a fully restored state upon remission treatment highlighting the specific and selective participation of adipocyte stroma in the chemotherapy context. The functional relevance of these dynamics was revealed through modelling studies demonstrating that adipocytes non- cell autonomously regulate ALL development by reducing proliferative capacity whilst simultaneously increasing leukaemia cell quiescence. more...