Similar studies for GEO DataSets (Select 200117902) - GEO DataSets

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Items: 10

Select item 2001179021.

Gene expression profiles of THP1 monocyte cells following Echinaforce treatment

(Submitter supplied) Until today, natural Echinacea purpurea extracts are widely used to prevent and treat respiratory trac infections. Although its immunomodulatory effects have already been demonstrated by several studies, the molecular mechanisms involved are not yet completely understood. In this study, we applied a systems biology approach by integrating transcriptome, kinome and methylome profiles of THP-1 monocyte cells treated with Echinaforce®, a commercial standardized ethanolic tincture of Echinacea purpurea. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
12 Samples

Download data: TXT

Series

Accession:: GSE117902

ID:: 200117902

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001179042.

Echinacea purpurea elicits anti-viral response in THP-1 monocytes through activation of interferon, MAPK and NF-κB signaling pathways and DNA hypermethylation of repeat elements

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Methylation profiling by genome tiling array

Platforms:: GPL21145 GPL10558
24 Samples

Download data

Series

Accession:: GSE117904

ID:: 200117904

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001179033.

DNA methylation profiles of THP1 monocyte cells following Echinaforce treatment

Organism:: Homo sapiens

Type:: Methylation profiling by genome tiling array

Platform:: GPL21145
12 Samples

Download data: TXT

Series

Accession:: GSE117903

ID:: 200117903

PubMed Full text in PMC Similar studies

Select item 2001896134.

Differential interferon-α immune signatures prevent SARS-CoV-2 infection

(Submitter supplied) Type 1 interferons (IFN-I) exert pleiotropic biological effects during viral infections, balancing virus control and immune-mediated pathology and have been successfully employed for the treatment of viral diseases. In humans, there are twelve IFN-alpha (α) subtypes, which activate downstream signalling cascades and result in a distinct pattern of immune responses and differential antiviral responses. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
60 Samples

Download data: XLSX

Series

Accession:: GSE189613

ID:: 200189613

PubMed Full text in PMC Similar studies

Select item 2001863605.

CCR2-dependent monocyte-derived cells restrict SARS-CoV-2 infection

(Submitter supplied) SARS-CoV-2 has caused a historic pandemic of respiratory disease (COVID-19) and current evidence suggests severe disease is associated with dysregulated immunity within the respiratory tract1,2. However, the innate immune mechanisms that mediate protection during COVID-19 are not well defined. Here we characterize a mouse model of SARS-CoV-2 infection and find that early CCR2-dependent infiltration of monocytes restricts viral burden in the lung. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
8 Samples

Download data: MTX, TSV

Series

Accession:: GSE186360

ID:: 200186360

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001596786.

Hydroxychloroquine inhibits trained immunity

(Submitter supplied) We demonstrate that hydroxychloroquine inhibits trained immunity at the functional and epigenetic level and is accompanied by reduced expression of interferon-stimulated genes. Trained immunity comprises a functional adaptation induced by epigenetic reprogramming which facilitates the anti-viral innate immune response.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
47 Samples

Download data: TSV

Series

Accession:: GSE159678

ID:: 200159678

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000122597.

Human dendritic cells treated with Echinacea purpurea phytocompounds

(Submitter supplied) This study investigated the specific and differential gene expression in human immature DCs (iDCs) in response to treatment with a butanol fraction containing defined bioactive phytocompounds extracted from stems and leaves of Echinacea purpurea

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3428
Platform:: GPL96
9 Samples

Download data: CEL, CHP

Series

Accession:: GSE12259

ID:: 200012259

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 34288.

Immature dendritic cell response to butanol fraction of Echinacea purpurea: time course

Analysis of immature dendritic cell lines (iDCs) treated with the butanol-fraction of stems and leaves of E. purpurea [BF/S+L/Ep] containing defined bioactive phytocompounds. Results provide insight into molecular mechanisms underlying the immune-modulatory activities induced by the phytocompounds.