Similar studies for GEO DataSets (Select 200124800) - GEO DataSets

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Items: 18

Select item 2001248001.

Rules governing translation selectivity under limiting ribosome availability

(Submitter supplied) Ribosomopathies are cell-type-specific pathologies related to a ribosomal protein (RP) gene insult. The 5q- syndrome is a somatic ribosomopathy linked to RPS14 gene haploinsufficiency and characterized by a prominent erythroid hypoplasia. Using quantitative proteomic, we show that GATA1 protein expression is low in shRPS14 cells in which ribosome quantities are diminished. Here, we investigated the cause of low GATA1 protein expression in limiting ribosome availability. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL24299
6 Samples

Download data: CEL, TXT

Series

Accession:: GSE124800

ID:: 200124800

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001088222.

Integrated analyses of translatome and proteome identify the rules of translation selectivity in RPS14-deficient

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL24299
21 Samples

Download data: CEL

Series

Accession:: GSE108822

ID:: 200108822

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Select item 2001088213.

mRNA length and 3’UTR structure govern the translation selectivity in RPS14-haploinsufficient erythroblasts [translatome]

(Submitter supplied) 5q- syndrome is a somatic ribosomopathy linked to the monoallelic deletion of the RPS14 gene and characterized by a proeminent erythroid phenotype. The mechanism of anemia involves an impaired differentiation and increased apoptosis of erythroblasts. Here we show that GATA1 protein expression is low in line with a defect in the representation of its mRNA at the ribosome. A global analysis of transcripts on polysomes indicates that translation is selective with a decreased representation of the transcripts with a short coding sequence and UTRs and a highly structured 3’UTR, a subset of transcripts that includes GATA1. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL24299
6 Samples

Download data: CEL

Series

Accession:: GSE108821

ID:: 200108821

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Select item 2001088204.

mRNA length and 3’UTR structure govern the translation selectivity in RPS14-haploinsufficient erythroblasts [transcriptome]

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL24299
9 Samples

Download data: CEL

Series

Accession:: GSE108820

ID:: 200108820

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Select item 2000094875.

Genome-wide expression profiling of cells infected with control or RPS14 shRNAs

(Submitter supplied) We performed genome-wide expression profiling of cells infected with control or RPS14 shRNAs. Keywords: controls vs. shRNA treated

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL3921
24 Samples

Download data: CEL, EXP

Series

Accession:: GSE9487

ID:: 200009487

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Select item 2000895406.

In vitro expansion of normal and Diamond Blackfan anemia-derived peripheral blood erythroid progenitors

(Submitter supplied) The Affymetrix Human Gene 2.0 ST array was used to measure differential expression of RNA isolated from normal and Diamond Blackfan anemia (DBA) erythroid progenitors after ex vivo expansion of circulating, peripheral blood derived hematopoietic stem cells under erythroid growth conditions. The gene-level probe summaries reported in this series were computed using RMA as implemented in the Bioconductor package Oligo v1.36.1. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
37 Samples

Download data: CEL

Series

Accession:: GSE89540

ID:: 200089540

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Select item 2000425707.

5q- Myelodysplastic Syndrome Masquerading as Diamond Blackfan Anemia

(Submitter supplied) Diamond Blackfan anemia is a congenital bone marrow failure syndrome characterized by hypoproliferative anemia, often with associated physical abnormalities. Perturbations of the ribosome appear critically important to the development of DBA, as alterations in 9 different ribosomal protein genes have been identified in multiple unrelated families, along with rarer abnormalities of additional ribosomal proteins. more...

Organism:: Homo sapiens

Type:: SNP genotyping by SNP array; Expression profiling by array

4 related Platforms
14 Samples

Download data: CEL, TXT

Series

Accession:: GSE42570

ID:: 200042570

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Select item 2000891838.

Consequences of Ribosomal Protein Haploinsufficiency in Human Hematopoiesis

(Submitter supplied) Ribosomal protein haploinsufficiency (RPH) underlies diverse human diseases with distinct and specific phenotypes, including Diamond-Blackfan anemia (DBA). Although multiple mechanisms have been proposed for the erythroid-specific hematopoietic defects observed in DBA, only recently has the role of selectively impaired translation been highlighted in these phenotypes. Exactly how and to what extent this impairment of translation occurs is currently unknown. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL16791
14 Samples

Download data: TXT

Series

Accession:: GSE89183

ID:: 200089183

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000949179.

Heme and GATA1 coordinately regulate erythroid differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Expression profiling by array

Platforms:: GPL19057 GPL6887
132 Samples

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Series

Accession:: GSE94917

ID:: 200094917

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009490510.

Heme and GATA1 coordinately regulate erythroid differentiation [expression]

(Submitter supplied) In mice lacking the heme exporter, FLVCR, differentiation fails at the CFU-E/proerythroblast stage from excessive heme and reactive oxygen species. We show that Flvcr1-deleted CFU-E/proerythroblasts have low GATA1 mRNA and GATA1-target gene mRNAs along with increased ribosomal protein mRNAs as a direct result of increased heme. Thus heme increases ribosomal protein transcription when globin production needs to be increased, and when heme is excessive, GATA1 is reduced allowing for normal termination of erythroid differentiation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6887
5 Samples

Download data: TXT

Series

Accession:: GSE94905

ID:: 200094905

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009489811.

Heme and GATA1 coordinately regulate erythroid differentiation [RNA-seq]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
127 Samples

Download data: TXT

Series

Accession:: GSE94898

ID:: 200094898

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002290312.

Ribosomal deficiencies in Diamond-Blackfan anemia impair translation of transcripts essential for differentiation of murine and human erythroblasts

(Submitter supplied) Diamond Blackfan Anemia (DBA) is associated with developmental defects and profound anemia. Mutations in genes encoding a ribosomal protein of the small (e.g. Rps19) or large (e.g. Rpl11) ribosomal subunit are found in over half of these patients. The mutations cause ribosomal haploinsufficiency, which reduces overall translation efficiency of cellular mRNAs. We reduced expression of *Rps19* or *Rpl11* in mouse erythroblasts and investigated mRNA polyribosome association, which revealed deregulated translation initiation of specific transcripts. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
24 Samples

Download data: CEL, TXT

Series

Accession:: GSE22903

ID:: 200022903

Select item 20004181713.

Gene expression analysis from erythroid progenitors of patients with Diamond-Blackfan anemia

(Submitter supplied) Gene expression analysis from erythroid progenitors (CD34+/CD71(high)/CD45- mononuclear cells from the bone marrow) of patients with Diamond-Blackfan anemia (due to RPS19 mutations) and control individuals.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16212
9 Samples

Download data: CEL

Series

Accession:: GSE41817

ID:: 200041817

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20006341314.

Murine Proerythroblasts (ProEs): WT vs. Bmi1-/-

(Submitter supplied) Transcriptional profiling of ProEs purified from wild type and Bmi1-/- mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7042
3 Samples

Download data: TXT

Series

Accession:: GSE63413

ID:: 200063413

PubMed Full text in PMC Similar studies

Select item 20006341115.

Murine Myeloid-Erythroid Progenitors (MEPs): WT vs. Bmi1-/-

(Submitter supplied) Transcriptional profiling of MEPs purified from wild type and Bmi1-/- mice.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL7042
3 Samples

Download data: TXT

Series

Accession:: GSE63411

ID:: 200063411

PubMed Full text in PMC Similar studies

Select item 20004159916.

Defective ribosomal protein gene expression alters transcription, translation, apoptosis, and oncogenic pathways in Diamond-Blackfan anemia.

(Submitter supplied) Transcriptome profile of highly purified multipotential (P), erythroid (E), and myeloid (M) bone marrow progenitors from three RPS19 mutated Diamond-Blackfan anemia and six control human subjects.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL96
27 Samples

Download data: CEL

Series

Accession:: GSE41599

ID:: 200041599

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20022236817.

Normal and ineffective erythropoiesis scRNA seq

(Submitter supplied) Ineffective erythropoiesis, the death of maturing erythroid cells, is a common cause of anemia. To better understand why this occurs, we studied the fates and adaptations of single erythroid marrow cells from individuals with Diamond Blackfan anemia (DBA), del(5q) myelodysplastic syndrome (del(5q) MDS), and normal controls, and defined an unhealthy (vs. healthy) differentiation trajectory, using velocity pseudotime and cell surface protein assessment. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL21697
37 Samples

Download data: H5AD

Series

Accession:: GSE222368

ID:: 200222368

PubMed Full text in PMC Similar studies

Select item 20004311718.

AB001

(Submitter supplied) Diamond-Blackfan anemia (DBA) is a congenital disorder that results predominantly from mutations in various ribosomal protein genes. In order to determine how these mutations affect the translation of specific mRNAs, we performed microarray analysis of polysomal transcripts isolated from lymphoblast cells derived from DBA patients carrying different haploinsufficient mutations in either RPS19 or RPL11. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL13183
18 Samples

Download data: TXT

Series

Accession:: GSE43117

ID:: 200043117

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