Similar studies for GEO DataSets (Select 200134440) - GEO DataSets

Select item 2001344401.

The Position Beta57 of IAg7 Controls the Early Anti-Insulin Response and Onset of Diabetes in NOD mice to Link MHC and Disease [RT-PCR]

(Submitter supplied) Abstract- The class II region of the Major Histocompatibility locus is the main contributor to the genetic susceptibility to type 1 diabetes (T1D). The loss of an aspartic acid at position 57 of diabetogenic HLA-DQ8 chains supports this association; it influences the recognition of peptides in the context of HLA-DQ8, and I-Ag7 using a mechanism termed the P9 switch. Here, we built register-specific insulin MHC tetramers, Ins12-20 and Ins13-21, to examine anti-insulin CD4 T cell responses during the early pre-diabetic phase of disease in mice. more...

Organism:: Mus musculus

Type:: Expression profiling by RT-PCR

Platform:: GPL26927
1829 Samples

Download data: CSV

Series

Accession:: GSE134440

ID:: 200134440

PubMed Full text in PMC Similar studies

Select item 2001348852.

The Position Beta57 of IAg7 Controls the Early Anti-Insulin Response and Onset of Diabetes in NOD mice to Link MHC and Disease

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by RT-PCR; Expression profiling by high throughput sequencing

Platforms:: GPL26927 GPL16417
1845 Samples

Download data: XLS, XLSX

Series

Accession:: GSE134885

ID:: 200134885

PubMed Full text in PMC Similar studies

Select item 2001348833.

The Position Beta57 of IAg7 Controls the Early Anti-Insulin Response and Onset of Diabetes in NOD mice to Link MHC and Disease [sequencing]

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16417
16 Samples

Download data: XLS, XLSX

Series

Accession:: GSE134883

ID:: 200134883

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000646744.

Genome-wide transcriptional analyses of islet-specific CD4+ T cells identify Idd9 genes controlling diabetogenic T cell function

(Submitter supplied) Analysis of gene expression levels in ex-vivo and p79-stimulated splenic CD4+ T cells.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL14828
12 Samples

Download data: TXT

Series

Accession:: GSE64674

ID:: 200064674

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000372945.

Comparison of gene expression in NOD versus NOD.NOR-Chr4 (NR4) splenic B cells.

(Submitter supplied) Type 1 Diabetes (T1D) in humans and the non-obese diabetic (NOD) mouse model results from autoreactive T cell destruction of pancreatic beta cells. A pathogenic role for B lymphocytes (B cells) in T1D first became evident when NOD mice made deficient in this population through introduction of an inactivated Igµ heavy chain gene (NOD.Igµnull) or chronic treatment with anti-IgM antibodies were strongly protected from disease. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Dataset:: GDS4340
Platform:: GPL1261
11 Samples

Download data: CEL

Series

Accession:: GSE37294

ID:: 200037294

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 43406.

Non-obese diabetic (NOD) and disease-resistant NOD.NOR-Chr4 models: splenic B cells

Analysis of anti-IgM-F(ab’)2 fragment-stimulated, splenic B cells from non-obese diabetic (NOD) or NR4 (NOD background with Chromosome 4, type 1 diabetes (T1D)-resistance alleles) females. Results provide insight into the molecular mechanisms underlying NOD and NR4 diabetogenic activity.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent, 2 strain sets

Platform:: GPL1261
Series:: GSE37294
11 Samples

Download data: CEL

DataSet

Accession:: GDS4340

ID:: 4340

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2002381467.

Regulatory T cells targeting a pathogenic MHC class II: Insulin peptide epitope postpone spontaneous autoimmune diabetes

(Submitter supplied) In spontaneous type 1 diabetes (T1D) non-obese diabetic (NOD) mice, the insulin B chain peptide 9-23 (B:9-23) can bind to the MHC class II molecule (IAg7) in register 3 (R3), creating a bimolecular IAg7/InsulinB:9-23 register 3 conformational epitope (InsB:R3). Previously, we showed that the InsB:R3-specific chimeric antigen receptor (CAR), constructed using an InsB:R3-monoclonal antibody, could guide CAR-expressing CD8 T cells to migrate to the islets and pancreatic lymph nodes. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24247
12 Samples

Download data: XLS

Series

Accession:: GSE238146

ID:: 200238146

PubMed Full text in PMC Similar studies

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