Similar studies for GEO DataSets (Select 200140754) - GEO DataSets

Select item 2001407541.

SAM68 is a splicing regulator in triple negative breast cancer

(Submitter supplied) SAM68 is an RNA binding protein frequently up-regulated in several human cancers and its oncogenic activity has often been associated with its splicing activity. Nevertheless, the genome-wide impact of SAM68 on the transcriptome of cancer cells is still unknown. Herein, by high-throughput RNA sequencing analysis of MDA-MB-231 SAM68-silenced cells, we uncover an extensive modulation of triple-negative breast cancer cell transcriptome by this splicing factor.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT

Series

Accession:: GSE140754

ID:: 200140754

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001408032.

NEK2 regulates triple negative breast cancer transcriptome.

(Submitter supplied) NEK2 is a mitotic kinase that is upregulated and mislocalized in the nucleus of human cancer cells. NEK2 modulates expression and activity of both transcription and splicing factors in cancer cells, nevertheless whether this kinase affects transcriptome regulation genome widely and whether this activity concurs to its oncogenic activity is still unknown. Herein, by high-throughput RNA sequencing analysis of MDA-MB-231 cells transiently silenced for NEK2 we uncover an extensive modulation of triple-negative breast cancer cell transcriptome by this kinase.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
6 Samples

Download data: TXT

Series

Accession:: GSE140803

ID:: 200140803

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000901453.

Expression data from triple negative breast cancer cells

(Submitter supplied) Treatment of triple-negative breast cancer has been challenging and paclitaxel resistance is one of the major obstacles to the better prognosis. Misregulation of alternative splicing (AS) may contribute to tumor progression and chemotherapy resistance. Human AS factor TRA2 has two separate gene paralogs encoding TRA2A and TRA2B proteins. TRA2B is associated with cancer cell survival and therapeutic sensitivity. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL17586 GPL17585
18 Samples

Download data: CEL, CHP

Series

Accession:: GSE90145

ID:: 200090145

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001102584.

SAM68-specific splicing is required for proper selection of alternative 3'UTR isoforms in the nervous system

(Submitter supplied) Neuronal alternative splicing is dynamically regulated in a spatiotemporal fashion. We previously found that STAR family proteins (SAM68, SLM1, SLM2) regulate spatiotemporal alternative splicing in the nervous system. However, the whole aspect of alternative splicing programs governed by STARs remains unclear. We deciphered the alternative splicing programs of SAM68 and SLM1 proteins using transcriptomics. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL19127
9 Samples

Download data: TXT

Series

Accession:: GSE110258

ID:: 200110258

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000389595.

Gene expression profiling of triple negative breast cancer, normal ductal cells, and normal tissues

(Submitter supplied) To identify novel molecular targets for triple negative breast cancer (TNBC), we have employed whole genome microarray expression profiling. We purified 30 surgically resected breast cancer tissue diagnosed triple negative by means of immunohistochemical staining and 13 normal mammary ductal cells with lasermicrobeam microdissection system (PALM MicroBeam, Carl Zeiss MicroImaging Co., Ltd), performed whole human genome microarray, and compared gene expression levels of TNBC, normal mammary ductal cells, and normal vital organs to develop molecular targets with a minimum risk.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4133
47 Samples

Download data: TXT

Series

Accession:: GSE38959

ID:: 200038959

Select item 2001144686.

Silencing of lnc-klhdc7b in the HCC1187 cell line

(Submitter supplied) By using shRNAs the lnc-klhdc7b was silenced in the cell line HCC1187, the shRNA-1 carried a ~75% silencing compared to the negative control (NC). We evaluated the role of LncKLHDC7B on oncogenic phenotypes in the IM breast cancer HCC1187 cell line model. The knockdown of LncKLHDC7B was achieved with ~75% of silencing efficiency. A complete genomic analysis of the transcriptomic state after silencing of LncKLHDC7B revealed an impact on the global expression of transcripts

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17586
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE114468

ID:: 200114468

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001229297.

Sam68 insures proper 3'-end pre-mRNA processing during germ cell differentiation

(Submitter supplied) Male germ cells express the widest repertoire of transcript variants in mammalian tissues. Nevertheless, factors and mechanisms underlying such pronounced diversity are largely unknown. The splicing regulator Sam68 is highly expressed in meiotic cells and its ablation results in defective spermatogenesis. Herein, we uncover an extensive splicing program operated by Sam68 across meiosis, primarily characterized by alternative last exon (ALE) regulation in genes of functional relevance for spermatogenesis. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13112
8 Samples

Download data: TXT

Series

Accession:: GSE122929

ID:: 200122929

PubMed Similar studies SRA Run Selector

Select item 2000980168.

Transcriptome analysis on TDP43 and SRSF3 downstream genes and binding RNAs in MDA-MB231 cells by Next Generation Sequencing

(Submitter supplied) TDP43 and SRSF3 has been reported to be RNA-binding proteins; however their roles in breast cancer progression has not been examined previously. Here, we performed RNA-seq on MDA-MB231 cells stably expressed sh-control, shTDP43, shSRSF3 or sh-TDP43 and sh-SRSF3 using lentivirus in duplicates. In addition, MDA-MB231 cells with stable expression of flag-TDP43 or flag-SRSF3 were also generated by using lentivirus. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platform:: GPL11154
12 Samples

Download data: TXT

Series

Accession:: GSE98016

ID:: 200098016

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

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