GEO DataSets

(Submitter supplied) Abstract from accompanying publication: "Bats host a number of viruses that cause severe disease in humans without experiencing overt symptoms of disease themselves. While the mechanisms underlying this ability to avoid sickness are not known, deep sequencing studies of bat genomes have uncovered genetic adaptations that may have functional importance in the antiviral response of these animals. Egyptian rousette bats (Rousettus aegyptiacus) are the natural reservoir hosts of Marburg virus (MARV). more...

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24487

66 Samples

Download data: TXT

(Submitter supplied) Study was performed in order to determine the scope of antiviral response of Rousettus aegyptiacus-derived fibroblasts to Sendai and Marburg virus infection. This study aids in understanding the function of the expanded immune repertoire of Rosettus aegyptiacus.

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24487

36 Samples

Download data: GFF, H5

(Submitter supplied) Study was performed in order to determine the type and scope of interferon response of Rousettus aegyptiacus-derived fibroblasts to Sendai virus infection. This study helps to understand the function of the expanded immune repertoire of Rosettus aegyptiacus.

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24487

18 Samples

Download data: GFF, H5

(Submitter supplied) Bats are reservoirs of a number of highly pathogenic human viruses, yet they remain relatively asymptomatic during infection. Whether this viral resistance is due to a unique immune system is unknown. An evolutionarily conserved feature of vertebrate antiviral immunity is the interferon (IFN) response, which triggers cellular defenses through interferon-stimulated gene (ISG) expression. While bats encode an intact IFN system, global ISG expression patterns in bat cells are not well characterized. more...

Organism:

Pteropus alecto

Type:

Expression profiling by high throughput sequencing

Platform:

GPL23872

15 Samples

Download data: TXT

(Submitter supplied) The response of bats to filoviral infections was studied to understand how they avoid getting sick

Organism:

Chiroptera

Type:

Expression profiling by high throughput sequencing

Platform:

GPL28706

179 Samples

Download data: CSV, FA

(Submitter supplied) Bats harbor high-impact zoonotic viruses in absence of clinical disease, which has been recently associated with unique features of their immune system. They seem to restrict inflammation and possibly limit disease manifestation to a minimum. In-depth characterization of cellular immunity in bats is yet largely missing, and imprinting of age and development on immune cell compartments remains unexplored. more...

Organism:

Rousettus aegyptiacus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL30616

4 Samples

Download data: MTX, TSV, TXT

(Submitter supplied) Marburg virus is a genetically simple RNA virus that causes a severe hemorrhagic fever upon infection in humans and non-human primates. The mechanism of how this pathogenesis comes about is not well understood, but it is well accepted that pathogenesis is significantly driven by a hyperactive immune response. To better understand the overall response to Marburg virus challenge, we undertook a transcriptomic analysis of immune cells circulating in the blood following aerosol exposure of cynomolgus macaques to a lethal dose of Marburg virus. more...

Organism:

Homo sapiens; Macaca fascicularis

Type:

Expression profiling by array

Platform:

GPL10332

30 Samples

Download data: TXT

(Submitter supplied) Lassa fever virus (LASV) is a significant human pathogen that is endemic to several countries in West Africa. Infection with Lassa leads to the development of hemorrhagic fever in a significant number of public health cases and it is considered a potential bioweapon. Little is known about the complex immune mechanisms governing response to LASV infection, or the genetic determinants of susceptibility and resistance to infection. more...

Organism:

Macaca fascicularis; Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

30 Samples

Download data: TXT