Similar studies for GEO DataSets (Select 200166991) - GEO DataSets

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Items: 17

Select item 2001669911.

Identification of JMJD1A and JMJD2B target genes in hypoxic colon carcinoma cells

(Submitter supplied) The Hypoxia-Inducible Factors induce the expression of the histone demethylases JMJD1A (KDM3A) and JMJD2B (KDM4B), linking the hypoxic tumor microenvironment to epigenetic mechanisms that may foster tumor progression. This dataset includes expression data obtained from exposing colon carcinoma cells to hypoxia in combination with siRNA-mediated knockdown of the hypoxia-inducible histone demethylases JMJD1A and JMJD2B.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
18 Samples

Download data: CEL

Series

Accession:: GSE166991

ID:: 200166991

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001670252.

Identification of JMJD1A and JMJD2B target genes in renal cell Carcinoma

(Submitter supplied) The Hypoxia-Inducible Factors induce the expression of the histone demethylases JMJD1A (KDM3A) and JMJD2B (KDM4B), linking the hypoxic tumor microenvironment to epigenetic mechanisms that may foster tumor progression. Using transcript profiling, we have identified genes that are regulated in RCC4 with siRNA-mediated knockdown of JMJD1A and JMJD2B. This dataset includes expression data obtained from renal cell Carcinoma being loss or mutation of the von Hippel-Lindau (VHL) tumor suppressor gene combination with siRNA-mediated knockdown of histone demethylases JMJD1A and JMJD2B.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
9 Samples

Download data: CEL

Series

Accession:: GSE167025

ID:: 200167025

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Select item 2000668943.

Identification of JMJD1A and JMJD2B Target Genes in Hypoxic Ovarian Cancer Cells

(Submitter supplied) The Hypoxia-Inducible Factors induce the expression of the histone demethylases JMJD1A (KDM3A) and JMJD2B (KDM4B), linking the hypoxic tumor microenvironment to epigenetic mechanisms that may foster tumor progression. Using transcript profiling, we have identified genes that are regulated by JMJD1A and JMJD2B in both normoxic and hypoxic conditions in SKOV3ip.1 ovarian cancer cells. This dataset includes expression data obtained from exposing ovarian cancer cells to hypoxia in combination with siRNA-mediated knockdown of the hypoxia-inducible histone demethylases JMJD1A and JMJD2B. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL5175
18 Samples

Download data: CEL

Series

Accession:: GSE66894

ID:: 200066894

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Select item 2001216424.

Histone demethylase KDM4B promotes DNA damage by activating long interspersed nuclear element-1

(Submitter supplied) We assess whole-genome H3K9me3 distribution in cancer cells and find that H3K9me3 is largely enriched in long interspersed nuclear element-1 (LINE-1). A significant proportion of KDM4B-dependent H3K9me3 was located in evolutionarily young LINE-1 elements, which likely retain retrotransposition activity. Ectopic expression of KDM4B promoted LINE-1 expression, while depletion of KDM4B reduced it. Furthermore, KDM4B overexpression enhanced LINE-1 retrotransposition efficacy, copy number, and associated DNA damage, presumably via the histone demethylase activity of KDM4B. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL20795
6 Samples

Download data: BED

Series

Accession:: GSE121642

ID:: 200121642

PubMed Similar studies SRA Run Selector

Select item 2001022905.

KDM4B epigenetically protects against obesity and metabolic dysfunction

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL1261 GPL19057
10 Samples

Download data: BED, CEL, CHP, WIG

Series

Accession:: GSE102290

ID:: 200102290

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Select item 2001022896.

KDM4B epigenetically protects against obesity and metabolic dysfunction [gene expression]

(Submitter supplied) KDM4B (lysine demethylase 4B) in adipose tissues plays a critical role in energy balance, oxidation, lipolysis and thermogenesis. Loss of KDM4B in mice resulted in obesity associated with reduced energy expenditure and impaired adaptive thermogenesis. Mechanistically, we determined that KDM4B directly controls the expression of multiple metabolic genes.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL1261
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE102289

ID:: 200102289

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Select item 2001021487.

KDM4B epigenetically protects against obesity and metabolic dysfunction [ChIP-seq]

(Submitter supplied) Preadiocyte of Kdm4b KO mice was infected with control or Flag-KDM4B retrovirus and were differentiated to adipocyte. The well-differentiated adipocytes were harvested for ChIP-Seq with Flag antibody.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19057
4 Samples

Download data: BED, WIG

Series

Accession:: GSE102148

ID:: 200102148

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001354278.

Identification of the KDM4B regulated transcriptome in the ER positive breast cancer cell line MCF-7

(Submitter supplied) To elucidate the KDM4B regulated transcriptomes in ER-positive breast cancer cells we assessed global gene expression changes in KDM4B-depleted MCF-7 cells by microarray analysis using the Illumina Human HT12 Version 4 BeadChip array. Differentially expressed genes were compared with KDM3A and FOXA1 regulated transcriptomes. We identified 229 genes co-regulated by all three enzymes and that co-regulated genes were involved in cell cycle processes. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
4 Samples

Download data: TXT

Series

Accession:: GSE135427

ID:: 200135427

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Select item 2001242709.

Identification of overlap between KDM3A and FOXA1 regulated transcriptome in the ER positive breast cancer cell line MCF-7

(Submitter supplied) To interrogate the extent of overlap between KDM3A and FOXA1 regulated transcriptomes in ER-positive breast cancer cells we assessed global gene expression changes in KDM3A-depleted and FOXA1-depleted MCF-7 cells by microarray analysis using the Illumina Human HT12 Version 4 BeadChip array. We identified that 43% of the KDM3A regulated transcriptome was also regulated by FOXA1 and that 43% of the FOXA1 regulated transcriptome was also regulated by KDM3A. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10558
9 Samples

Download data: TXT

Series

Accession:: GSE124270

ID:: 200124270

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Select item 20013967810.

Hypoxia-mediated regulation of histone demethylases affects angiogenesis associated functions in endothelial cells

(Submitter supplied) Purpose: Jumonji-containing (jmjC) family of proteins are involved in epigenetic gene regulation through histone specific lysine demethylation. Previous studies have demonstrated that the expression of several members of this family is induced by hypoxia. However, the mechanisms by which lysine specific demethylases (KDMs) are regulated under hypoxia and how they affect angiogenesis, the primary method to restore blood oxygen, remains unknown. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
24 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE139678

ID:: 200139678

Select item 20010770311.

Transcriptomic analysis of KDM4B-mediated genes in AGS cells

(Submitter supplied) KDM4B, an important epigenetic regulator of cell proliferation, metastasis and genome stability, is often overexpressed in gastric cancer. Notably, elevated expression of KDM4B is associated with a poor clinical outcome. A global transcriptomic analysis between KDM4B control and KDM4B-knockdown AGS cells without or with Helicobacter pylori challenge reveals differentially expressed genes involved in response to virus, multi-organism process, and response to stimulus, suggesting KDM4B as an inducible epigenetic factor under H. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL16686
4 Samples

Download data: CEL

Series

Accession:: GSE107703

ID:: 200107703

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Select item 20011970212.

Effect of Fbxo22 on ER and SRC-3 recruitment to the genomic loci

(Submitter supplied) The agonistic/antagonistic bio-character of selective estrogen receptor modulators (SERMs) can have therapeutic advantages, particularly in the case of premenopausal breast cancers. Although the contradictory effects of these modulators have been studied in terms of cross-talk between estrogen receptor (ER)-coactivator dynamics and growth factor signaling, the molecular basis of these mechanisms is still obscure. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL9052
8 Samples

Download data: TXT

Series

Accession:: GSE119702

ID:: 200119702

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Select item 20015412513.

KDM4B-CCAR1-Mediator axis is a critical regulator of osteoclast differentiation and bone homeostasis

(Submitter supplied) Bone undergoes a constant and continuous remodeling process which is tightly regulated by the coordinated and the sequential action of bone-resorbing osteoclasts and bone-forming osteoblasts. Recent studies have shown that histone demethylases are implicated in osteoblastogenesis. However, little is known about the role of histone demethylases in osteoclast formation. Here, we identify KDM4B as an epigenetic regulator of osteoclast differentiation.Our biochemical analysis revealed that KDM4B physically and functionally associates with CCAR1 and Med complex. more...

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL17021
5 Samples

Download data: BIGWIG

Series

Accession:: GSE154125

ID:: 200154125

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20003697014.

KDM4B- and KDM6B-regulated genes in human mesenchymal stem cell osteogenic differentiation

(Submitter supplied) To investigate how histone demethylases KDM4B and KDM6B may be involved in osteogenic commitment of mesenchymal stem cells (MSCs), we performed gene expression profiling and comparison on control, KDM4B- and KDM6B-knockdown MSCs at different stages of osteogenic differentiation.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
9 Samples

Download data: CEL, CHP, JPG

Series

Accession:: GSE36970

ID:: 200036970

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20013992715.

LSD1 mediates AKT activity in PIK3CA mutant colorectal cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL18573
30 Samples

Download data: BIGWIG

Series

Accession:: GSE139927

ID:: 200139927

PubMed Full text in PMC Similar studies

Select item 20013992516.

LSD1 mediates AKT activity in PIK3CA mutant colorectal cancer [ChIP-Seq]

(Submitter supplied) Activation of the epithelial-mesenchymal transition (EMT) program is a critical mechanism for initiating cancer progression and migration. Colorectal cancers (CRCs) contain many genetic and epigenetic alterations that can contribute to EMT. Mutations activating the PI3K/AKT signaling pathway are observed in >40% of patients with CRC contributing to increased invasion and metastasis. Little is known about how oncogenic signaling pathways such as PI3K/AKT synergize with chromatin modifiers to activate the EMT program. more...