Similar studies for GEO DataSets (Select 200182033) - GEO DataSets

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Items: 11

Select item 2001820331.

SUM159 cells grown in 2D cultures in the presence or absence of SHP2

(Submitter supplied) The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix receptors. In malignancies, SHP2 is hyperactivated either downstream of oncoproteins or by mutations.We provide analysis of the human mesenchymal triple-negative breast cancer cell line SUM159 and grown in 2D cultures for 15 days in the presence or absence of SHP2.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
7 Samples

Download data: CEL

Series

Accession:: GSE182033

ID:: 200182033

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000351182.

Primary TNBC tumor in the presence or absence of SHP2

(Submitter supplied) The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix receptors. In malignancies, SHP2 is hyperactivated either downstream of oncoproteins or by mutations.We provide analysis of a primary triple-negative breast tumor grown as xenografts in the presence or absence of SHP2 for 30 days.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
14 Samples

Download data: CEL

Series

Accession:: GSE35118

ID:: 200035118

Select item 2000345253.

BT474 tumors, primary TN tumors and MCF10A-HER2/3 cells in the presence or absence of SHP2

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
36 Samples

Download data: CEL

Series

Accession:: GSE34525

ID:: 200034525

Select item 2000345244.

MCF10A-HER2/3 cells grown in 3D cultures in the presence or absence of SHP2

(Submitter supplied) The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix receptors. In malignancies, SHP2 is hyperactivated either downstream of oncoproteins or by mutations.We provide analysis of the mammary epithelial cells MCF10A overexpressing human HER2 and HER3 and grown in 3D cultures for 15 days in the presence or absence of SHP2.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
6 Samples

Download data: CEL

Series

Accession:: GSE34524

ID:: 200034524

Select item 2000345235.

BT474 tumors in the presence or absence of SHP2

(Submitter supplied) The first bona fide PTP proto-oncogene was the Src-homology 2 domain-containing phosphatase SHP2 (encoded by PTPN11), an ubiquitously expressed PTP that transduces mitogenic, pro-survival, cell fate and/or pro-migratory signals from numerous growth factor-, cytokine- and extracellular matrix receptors. In malignancies, SHP2 is hyperactivated either downstream of oncoproteins or by mutations.We provide analysis of the breast cancer cells BT474 grown as xenografts in the presence or absence of SHP2 for 30 days.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
16 Samples

Download data: CEL

Series

Accession:: GSE34523

ID:: 200034523

Select item 2001280516.

SHP2 Blockade Sensitizes Metastatic Triple Negative Breast Cancer to PI3K Inhibition

(Submitter supplied) Next Generation Sequencing was applied to investigate the effects of PI3K inhibition and/or SHP2 inhibition on the mouse mammary carcinoma 4T1.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
18 Samples

Download data: CSV

Series

Accession:: GSE128051

ID:: 200128051

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001092707.

RNA seq_PDX2_SHP099

(Submitter supplied) RNA seq data of PDX2 treated with vehicle of SHP099 --> to check senescence and SASP gene expression signatures

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
12 Samples

Download data: XLSX

Series

Accession:: GSE109270

ID:: 200109270

Select item 2000505188.

Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL1261 GPL8321
24 Samples

Download data: CEL, CHP

Series

Accession:: GSE50518

ID:: 200050518

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000505179.

Shp2 Signaling Suppresses Senescence in PyMT-induced Mammary Gland Cancer in Mice [Mouse430_2 array]

(Submitter supplied) In this study, we have used techniques from cell biology, biochemistry, and genetics to investigate the role of the tyrosine phosphatase Shp2 in tumor cells of MMTV-PyMT mouse mammary glands. Genetic ablation or pharmacological inhibition of Shp2 induces senescence, as determined by the activation of senescence-associated β-gal (SA-β-gal), cyclin-dependent kinase inhibitor 1B (p27), p53, and histone 3 trimethylated lysine 9 (H3K9me3). more...