GEO DataSets

(Submitter supplied) To gain further insight into potential specific gene signatures expressed by pancreatic islet cells and pathogenic CD4+ T lymphocytes isolated from sublines of non-obese diabetic (NOD) mice expressing high or low autoimmune (type 1) diabetes incidence.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL10787

50 Samples

Download data: TXT

(Submitter supplied) Analysis of gene expression levels in ex-vivo and p79-stimulated splenic CD4+ T cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL14828

12 Samples

Download data: TXT

(Submitter supplied) Type 1 Diabetes (T1D) in humans and the non-obese diabetic (NOD) mouse model results from autoreactive T cell destruction of pancreatic beta cells. A pathogenic role for B lymphocytes (B cells) in T1D first became evident when NOD mice made deficient in this population through introduction of an inactivated Igµ heavy chain gene (NOD.Igµnull) or chronic treatment with anti-IgM antibodies were strongly protected from disease. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4340

Platform:

GPL1261

11 Samples

Download data: CEL

Analysis of anti-IgM-F(ab’)2 fragment-stimulated, splenic B cells from non-obese diabetic (NOD) or NR4 (NOD background with Chromosome 4, type 1 diabetes (T1D)-resistance alleles) females. Results provide insight into the molecular mechanisms underlying NOD and NR4 diabetogenic activity.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 agent, 2 strain sets

Platform:

GPL1261

Series:

GSE37294

11 Samples

Download data: CEL

(Submitter supplied) Prior to the onset of autoimmune destruction, type 1 diabetic patients and an animal model thereof, the nonobese diabetic (NOD) mouse, show morphological and functional abnormalities in target organs, which may act as inciting events for leukocyte infiltration. To better understand these abnormalities, but without the complications associated with inflammatory infiltrates, we examined genes expressed in autoimmune target tissues (pancreas, submandibular glands, and lacrimal glands) of NOD/scid mice and of autoimmune-resistant C57BL6/scid mice. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Datasets:

GDS2177 GDS2178 GDS2179

Platforms:

GPL81 GPL82 GPL83

117 Samples

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Analysis of pancreata and submandibular and lacrimal glands from 6-, 9-, and 15-week-old NOD/scid animals, respectively, before the onset of autoimmune destruction of the tissues. The NOD/scid animal is a model for type 1 diabetes. The three organs examined are autoimmune targets in type 1 diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 2 strain, 3 tissue sets

Platform:

GPL83

Series:

GSE4953

39 Samples

Download data

Analysis of pancreata and submandibular and lacrimal glands from 6-, 9-, and 15-week-old NOD/scid animals, respectively, before the onset of autoimmune destruction of the tissues. The NOD/scid animal is a model for type 1 diabetes. The three organs examined are autoimmune targets in type 1 diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 2 strain, 3 tissue sets

Platform:

GPL82

Series:

GSE4953

39 Samples

Download data

Analysis of pancreata and submandibular and lacrimal glands from 6-, 9-, and 15-week-old NOD/scid animals, respectively, before the onset of autoimmune destruction of the tissues. The NOD/scid animal is a model for type 1 diabetes. The three organs examined are autoimmune targets in type 1 diabetes.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 3 age, 2 strain, 3 tissue sets

Platform:

GPL81

Series:

GSE4953

39 Samples

Download data