Similar studies for GEO DataSets (Select 200188958) - GEO DataSets

Select item 2001889581.

GCN2 kinase Activation by ATP-competitive Kinase Inhibitors

(Submitter supplied) Purpose: Use next generation sequencing to determine which CRISPR knockouts confer resistance to EGFR inhibitors and to determine which cellular pathways get upregulated in response to neratinib.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Other

Platforms:: GPL11154 GPL18573 GPL15520
29 Samples

Download data: RESULTS, TXT

Series

Accession:: GSE188958

ID:: 200188958

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001287302.

RNAseq of parental and neratinib resistant 5637 and OVCAR8 cells with or withour neratinib treatment

(Submitter supplied) Pan-HER TKI neratinib has demonstrated clinical activity in patients with HER2-mutant cancers. However responses are heterogenoeus and not generally prolonged, suggesting de-novo and acquired resistance to neratinib. To study mechanisms of resistance to neratinib we generated neratinib resistant cells by gradual dose escalation until resistance was achieved and performed various analyses including RNAseq.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
24 Samples

Download data: TXT

Series

Accession:: GSE128730

ID:: 200128730

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2001349173.

CHO_library_B_GCN Screen

(Submitter supplied) CRISPR screen targeting 3022 CHO (Chinese hamster) genes to identify those contributing to induction of the Integrated Stress Response by histidinol treatment.

Organism:: Cricetulus griseus; synthetic construct

Type:: Other

Platforms:: GPL26968 GPL26969 GPL26967
16 Samples

Download data: TXT, XLS

Series

Accession:: GSE134917

ID:: 200134917

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001140614.

Small molecule inhibition of MEK activates Wnt signalling and leads to reprogramming of colon cancer stem cells

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platforms:: GPL10558 GPL570
28 Samples

Download data: CEL

Series

Accession:: GSE114061

ID:: 200114061

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001140605.

Small molecule inhibition of MEK activates Wnt signalling and leads to reprogramming of colon cancer stem cells [Affymetrix]

(Submitter supplied) Resistance to Ras pathway inhibition is a major challenge in the treatment of colorectal cancer (CRC), but the underlying mechanisms are incompletely understood. Here we performed large-scale small molecule screens in CRC and identified inhibitors of MEK1/2 as potent activators of Wnt/beta-catenin signalling. Targeting MEK increased Wnt activity in different CRC cell lines and in the murine intestine in vivo. more...