Similar studies for GEO DataSets (Select 200197293) - GEO DataSets

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Items: 20

Select item 2001972931.

Inhibition of histone acetyltransferase attenuates 3D chromatin-mediated insulin signaling in pancreatic cancer (Hi-C dataset)

(Submitter supplied) Inhibition of histone acetyltransferase has been widely used to be effectively treat cancers in many studies. However, it’s not clear how the downstream signaling responds to the inhibitor in pancreatic cancer. Here we performed Hi-C experiments to canonical and patient-derived pancreatic cancer cells with the treatment of small molecule inhibitor ICG-001 which has dual function to block both WNT signaling and histone acetyltransferase. more...

Organism:: Homo sapiens

Type:: Other

Platform:: GPL21290
8 Samples

Download data: TXT

Series

Accession:: GSE197293

ID:: 200197293

PubMed Full text in PMC Similar studies

Select item 2001984442.

Inhibition of histone acetyltransferase attenuates 3D chromatin-mediated insulin signaling in pancreatic cancer (RNAseq dataset)

(Submitter supplied) Inhibition of histone acetyltransferase has been widely used to be effectively treat cancers in many studies. However, it’s not clear how the downstream signaling responds to the inhibitor in pancreatic cancer. Here we performed Hi-C experiments and RNA-seq to canonical and patient-derived pancreatic cancer cells with the treatment of small molecule inhibitor ICG-001 which has dual function to block both WNT signaling and histone acetyltransferase. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
24 Samples

Download data: TXT

Series

Accession:: GSE198444

ID:: 200198444

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000957043.

Targeting oncogenic β-catenin/CBP activity for the treatment of head and neck squamous cell carcinoma

(Submitter supplied) Head and neck squamous cell carcinoma (HNSCC) presents primarily as oral squamous cell carcinoma (OSCC), an aggressive malignancy characterized by heterogeneity, locoregional metastases and resistance to existing treatments. Although a number of molecular alterations associated with OSCC have been identified, they have had limited impact on clinical management. A frequent feature of OSCC is the inappropriate activation of nuclear β-catenin. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17930
18 Samples

Download data: CEL

Series

Accession:: GSE95704

ID:: 200095704

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000640394.

Altering cancer transcriptomes using epigenomic inhibitors

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by array; Expression profiling by high throughput sequencing

Platforms:: GPL11154 GPL10904
18 Samples

Download data: IDAT

Series

Accession:: GSE64039

ID:: 200064039

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000640385.

Altering cancer transcriptomes using epigenomic inhibitors [Illumina beadchip]

(Submitter supplied) We have compared the genome-wide effects on the transcriptome after treatment with ICG-001 (the specific CBP inhibitor) versus C646, a compound that competes with acetyl-coA for the Lys-coA binding pocket of both CBP and p300. We found that both drugs cause large-scale changes in the transcriptome of HCT116 colon cancer cells and PANC1 pancreatic cancer cells, and reverse some tumor-specific changes in gene expression. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL10904
12 Samples

Download data: IDAT

Series

Accession:: GSE64038

ID:: 200064038

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000637766.

Altering cancer transcriptomes using epigenomic inhibitors [RNA-Seq]

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE63776

ID:: 200063776

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000577287.

Expression data from AsPC1 cells treated with ICG-001

(Submitter supplied) The CREB binding protein inhibitor ICG-001 suppresses pancreatic cancer growth We used microarrays to detail global gene expression changes in the pancreatic cancer cell line AsPC1 following treatment with ICG-001 or siRNA-mediated knockdown of CTNNB1 (beta-catenin)

Organism:: Homo sapiens

Type:: Expression profiling by array

Datasets:: GDS5323 GDS5324
Platform:: GPL570
16 Samples

Download data: CEL

Series

Accession:: GSE57728

ID:: 200057728

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 53248.

Beta-catenin depletion effect on pancreatic cancer cell line

Analysis of AsPc1 pancreatic adenocarcinoma cells depleted for beta-catenin. Dysregulation of Wnt/β-catenin signaling is implicated in the pathogenesis of cancers. Results compared to those from AsPC1 cells treated with the CREB-binding protein inhibitor ICG-001 (GDS5323).

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL570
Series:: GSE57728
4 Samples

Download data: CEL

DataSet

Accession:: GDS5324

ID:: 5324

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 53239.

CREB-Binding Protein Inhibitor ICG-001 effect on pancreatic cancer cell line: time course

Analysis of AsPC1 pancreatic adenocarcinoma (PDAC) cells treated with IGC-001 up to 24 hours. IGC-001 binds to CREB-binding protein to disrupt its interaction with β-catenin. Results compared to β-catenin depletion (GDS5324) and provide insight into the therapeutic potential of IGC-001 in PDAC.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 agent, 2 time sets

Platform:: GPL570
Series:: GSE57728
12 Samples

Download data: CEL

DataSet

Accession:: GDS5323

ID:: 5323

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20022179510.

E-7386 IS NOT A SPECIFIC CBP/β-CATENIN ANTAGONIST

(Submitter supplied) Our data show that E-7386 which has been reported to be a “first-in-class orally active CBP/beta-catenin modulator” anticancer agent, unfortunately by multiple criteria does not appear to be a bona fide CBP/β-catenin selective

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
4 Samples

Download data: TXT

Series

Accession:: GSE221795

ID:: 200221795

Select item 20004458711.

Crizotinib inhibits metabolic inactivation of gemcitabine in ortothopic pancreatic tumors derived from primary cells with c-Met overexpression

(Submitter supplied) Pancreatic ductal adenocarcinoma (PDAC) remains a major unsolved health problem. Most drugs that pass preclinical tests fail in these patients, emphasizing the need of appropriate preclinical models to test novel anticancer strategies. We developed four orthotopic mouse models employing primary human PDAC cells expressing Firefly and Gaussia luciferases, enabling bioluminescence monitoring of tumor growth and metastasis formation. more...

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL16694
8 Samples

Download data: TXT

Series

Accession:: GSE44587

ID:: 200044587

PubMed Full text in PMC Similar studies

Select item 20016557212.

Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Other; Expression profiling by high throughput sequencing

Platform:: GPL21290
18 Samples

Download data

Series

Accession:: GSE165572

ID:: 200165572

PubMed Full text in PMC Similar studies

Select item 20016557113.

Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance [RNA-Seq]

(Submitter supplied) Organoids or spheroids have emerged as a physiologically relevant in vitro preclinical model to study patient-specific diseases. A recent study used spheroids of MCF10 cells to model breast cancer progression and identified targetable alterations more similar to those in vivo. Thus, it is practical and essential to explore and characterize the spheroids of the commonly used human breast cancer (BC) cells. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL21290
12 Samples

Download data: TXT, XLSX

Series

Accession:: GSE165571

ID:: 200165571

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 20016557014.

Hi-C profiling of cancer spheroids identifies 3D-growth-specific chromatin interactions in breast cancer endocrine resistance [Hi-C]

Organism:: Homo sapiens

Type:: Other

Platform:: GPL21290
6 Samples

Download data: XLSX

Series

Accession:: GSE165570

ID:: 200165570

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20019037715.

Microarray expression data of E7386-treated HSC3 cells

(Submitter supplied) E7386 inhibits interaction between B-catenin and CREB-binding protein (CBP), which drives oncogenic gene expression and aggressive cancer phenotypes in oral squamous cell carcinomas (OSCC). We use microarrays to profile the effects of E7386 treatment on gene expression of HSC3 human OSCC cells.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL17930
6 Samples

Download data: CEL

Series

Accession:: GSE190377

ID:: 200190377

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20015871316.

Gene expression profiling using RNA-Seq data of MMTV-Wnt1 tumor tissue from mice treated with E7386

(Submitter supplied) We conducted an RNA-Seq analysis using total RNA extracted from MMTV-Wnt1 tumor tissues resected from mice orally administered E7386 at 25 or 50 mg/kg twice daily, or vehicle, for 3 days (Day 4) or 7 days (Day 8) and examined the differentially expressed gene levels compared with vehicle at days 4 and 8.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19057
24 Samples

Download data: XLSX

Series

Accession:: GSE158713

ID:: 200158713

PubMed Similar studies SRA Run Selector

Select item 20015855417.

Effect of E7386 on gene expression chenges in whisler follicle tissues of ApcMin/+ mice

(Submitter supplied) Gene expression profiling of whisker follicle tissues of ApcMin/+ mice treated with E7386

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL10787
8 Samples

Download data: TXT

Series

Accession:: GSE158554

ID:: 200158554

Select item 20014438018.

The 3D Genomic Landscape of Differential Response to EGFR/HER2 Inhibition in Endocrine-Resistant Breast Cancer

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Other; Expression profiling by high throughput sequencing

Platform:: GPL21290
24 Samples

Download data

Series

Accession:: GSE144380

ID:: 200144380

PubMed Full text in PMC Similar studies

Select item 20014437819.

The 3D Genomic Landscape of Differential Response to EGFR/HER2 Inhibition in Endocrine-Resistant Breast Cancer [RNA-seq]

(Submitter supplied) Recent studies suggested that crosstalk between ERα and EGFR/HER2 pathways plays a critical role in mediating endocrine therapy resistance. Several targeting EGFR/HER2 signaling inhibitors including FDA-approved lapatinib and gefitinib as well as a novel dual tyrosine kinase inhibitor (TKI) sapitnib showed greater inhibitory efficacies. However, how a 3D chromatin landscape of the response to the inhibition to EGFR/HER2 pathway remains to be elucidated. more...