Similar studies for GEO DataSets (Select 200199775) - GEO DataSets

Select item 2001997751.

mRNA sequencing of breast cancer brain metastasis tumors FACS sorted for E-cadherin high and low levels

(Submitter supplied) In this study we want to compare the expression profiles of E-cadherin high and low tumor cells from 4 different mice with breast cancer brain metastasis. We used a breast cancer brain metastasis model derived from the PyMT E-cadherin-mCFP breast cancer model (Beerling et al. Cell Reports 2016) and FACS sorted samples based on endogenous E-cadherin-mCFP expression.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17021
8 Samples

Download data: TXT

Series

Accession:: GSE199775

ID:: 200199775

PubMed Full text in PMC Similar studies

Select item 2000771072.

Plasticity between Epithelial and Mesenchymal States Unlinks EMT from Metastasis-Enhancing Stem Cell Capacity

(Submitter supplied) In this study we studied the presence of tumor cells that underwent epithelial-to-mesenchymal transition within polyoma middle T antigen (PyMT) breast tumors. For this we dissociated tumors and isolated Ecad positive tumor cells by FACS sorting. We confirmed that PyMT tumors contain a small set of tumor cells that have undergone EMT in the primary tumor and that E-cadherin can be used as a marker on single cell level for mesenchymal status in this model.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL19057
7 Samples

Download data: CSV, TXT

Series

Accession:: GSE77107

ID:: 200077107

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2001005343.

Expression profiling in breast cancer brain metastases compared to breast cancers and primary brain tumors

(Submitter supplied) Experiment: Expression profiling in breast cancer brain metastases (BC) compared to breast cancers (BC) and primary brain tumors (prBT). The objectives are to identify expression profiles that are specific to BCBM in order to identify new molecular biomarkers. The characterization of the BCBM samples included adjacent genetic techniques.

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6244
35 Samples

Download data: CEL

Series

Accession:: GSE100534

ID:: 200100534

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000810334.

E-cadherin re-expression shows in vivo evidence for mesenchymal to epithelial transition in clonal metastatic breast tumor cells

(Submitter supplied) Substantial experimental evidence has shown that dedifferentiation from an epithelial state to a mesenchymal-like state (EMT) drives tumor cell metastasis. This transition facilitates tumor cells to acquire motility and invasive features. Intriguingly, tumor cells at the metastatic site are primarily epithelial, and it is believed that they re-differentiate back to an epithelial state by a process called mesenchymal to epithelial transition (MET). more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL6246
4 Samples

Download data: CEL

Series

Accession:: GSE81033

ID:: 200081033

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000585605.

TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis

(Submitter supplied) Using a TWIST1-inducible epithelial-to-mesenchymal transition (EMT) model in HMLE cells, miRNA changes were profiled at different time points during an active EMT.

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by array

Platform:: GPL18795
12 Samples

Download data: TXT

Series

Accession:: GSE58560

ID:: 200058560

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000545056.

TWIST1-induced microRNA-424 drives an intermediate epithelial-to-mesenchymal transition that opposes metastasis

(Submitter supplied) Epithelial-to-mesenchymal transition (EMT) is a dynamic process that relies on cellular plasticity; an EMT/MET axis is critical for metastatic colonization of carcinomas. Unlike epithelial programming, regulation of mesenchymal programming is not well understood in EMT. Here we describe the first microRNA that enhances exclusively mesenchymal programming. We demonstrate that microRNA-424 is up-regulated early during a TWIST1/SNAI1-induced EMT, and that it causes cells to express mesenchymal genes without affecting epithelial genes, resulting in a mixed/intermediate EMT. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: TXT

Series

Accession:: GSE54505

ID:: 200054505

PubMed Full text in PMC Similar studies Analyze with GEO2R SRA Run Selector

Select item 2000084307.

Identification of EMT related genes in mcf10 cell line

(Submitter supplied) In vitro studies on immortalized breast MCF10A cells were additionally performed to assess the phenotypic and genetic changes associated to mesenchymal transformation of breast cells and to their epithelial plasticity. Keywords: breast cancer

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL4338
6 Samples

Download data: GPS, TIFF

Series

Accession:: GSE8430

ID:: 200008430

Select item 2001719408.

Trajectories of partial and full EMT of mammary tumor cells in the MMTV-PyMT mouse model

(Submitter supplied) Epithelial-mesenchymal transition (EMT) is a multistep process of cell de-differentiation which confers carcinoma cells with a variety of malignant characteristics. Due to the transient and reversible nature of the process, cancer cells may transit between various stages of an EMT continuum, including epithelial, partial EMT or full EMT, and the actual status of cancer cells, the kinetics of cellular state transition in vivo and the consequences thereof have remained elusive. more...