Similar studies for GEO DataSets (Select 200209797) - GEO DataSets

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Items: 2

Select item 2002097971.

The highly conserved RNA-binding specificity of nucleocapsid protein facilitates the identification of drugs with broad anti-coronavirus activity.

(Submitter supplied) We performed the high-throughput RNA-SELEX (HTR-SELEX) to determine the RNA-binding specificity of the N proteins of various SARS-CoV-2 variants as well as other β-coronaviruses and showed that N proteins could bind two unrelated sequences, both of which were highly conserved across all variants and species.

Organism:: Escherichia coli

Type:: Other

Platform:: GPL28756
72 Samples

Download data: XLSX

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Accession:: GSE209797

ID:: 200209797

PubMed Full text in PMC Similar studies

Select item 2001671312.

Host-virus chimeric events in SARS-CoV2 infected cells are infrequent and artifactual

(Submitter supplied) Pathogenic mechanisms underlying severe SARS-CoV2 infection remain largely unelucidated. High-throughput sequencing technologies that capture genome and transcriptome information are key approaches to gain detailed mechanistic insights from infected cells. These techniques readily detect both pathogen and host-derived sequences, providing a means of studying host-pathogen interactions. Recent studies have reported the presence of host-virus chimeric (HVC) RNA in RNA-seq data from SARS-CoV2 infected cells and interpreted these findings as evidence of viral integration in the human genome as a pathogenic mechanism. more...