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Links from GEO DataSets

Items: 10

1.

Genomic testing in early localized prostate cancer may define subsets of African Americans with aggressive disease—a prospective study

(Submitter supplied) Gene expression study of the VANDAAM Phase II clinical trial
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
226 Samples
Download data: CEL
Series
Accession:
GSE209954
ID:
200209954
2.

A genomic classifier improves prediction of metastatic disease within 5 years after surgery in node-negative high-risk prostate cancer patients managed by radical prostatectomy without adjuvant therapy

(Submitter supplied) To determine whether adding Decipher to standard risk stratification tools (CAPRA-S and Stephenson nomogram) improves accuracy in prediction of metastatic disease within 5 years after surgery in men with adverse pathologic features after RP.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5188
182 Samples
Download data: CEL
Series
Accession:
GSE62667
ID:
200062667
3.

Tissue-based Genomics Augments Post-prostatectomy Risk Stratification in a Natural History Cohort of Intermediate- and High-Risk Men

(Submitter supplied) Radical prostatectomy (RP) is a primary treatment option for men with intermediate- and high-risk prostate cancer. Although many are effectively cured with local therapy alone, these men are by definition at higher risk of adverse pathologic features. It has been shown previously that genomic data can be used to predict tumor aggressiveness. Our objective was to evaluate genomic data and it's relationship to pathological stage and grade in a cohort of men that received no treatment other than radical prostatectomy surgery.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5188
260 Samples
Download data: CEL, CSV
Series
Accession:
GSE79957
ID:
200079957
4.

Expression data of candidates for prostate cancer active surveillance

(Submitter supplied) The dataset consists of 266 NCCN very low/low or favorable-intermediate risk PCa patients who underwent diagnostic prostate biopsy between 2000 and 2014 and were treated with RP in six community or academic practices: University of Calgary, Cedars-Sinai, Spectrum Health, Cleveland Clinic, MD Anderson Cancer Center and Johns Hopkins. All patients had complete tumor pathology from biopsy and prostatectomy. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5188
266 Samples
Download data: CEL, CSV
Series
Accession:
GSE119616
ID:
200119616
5.

Genes associated with prostate cancer are differentially expressed in African American and European American men

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16230
802 Samples
Download data
Series
Accession:
GSE41969
ID:
200041969
6.

Genes associated with prostate cancer are differentially expressed in African American and European American men (matched normal specimens)

(Submitter supplied) A total of 1,507 probes measured the expression of 517 genes on the custom Illumina DASL assay testing if select genes showed cancer-specific differential expression according to race. Genes were chosen for inclusion in the assay based on existing evidence from the literature and our own data for their importance to prostate cancer, prostate cancer aggressiveness, or cancer in general
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16230
163 Samples
Download data: TXT
Series
Accession:
GSE41968
ID:
200041968
7.

Genes associated with prostate cancer are differentially expressed in African American and European American men (tumor specimens)

(Submitter supplied) A total of 1,507 probes measured the expression of 517 genes on the custom Illumina DASL assay testing if select genes showed cancer-specific differential expression according to race. Genes were chosen for inclusion in the assay based on existing evidence from the literature and our own data for their importance to prostate cancer, prostate cancer aggressiveness, or cancer in general.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL16230
639 Samples
Download data: TXT
Series
Accession:
GSE41967
ID:
200041967
8.

Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
838 Samples
Download data: CEL
Series
Accession:
GSE157548
ID:
200157548
9.

Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Validation Cohort]

(Submitter supplied) Black men die more often of prostate cancer (PC) yet, interestingly, may derive greater survival benefits from immunotherapy. Since no signatures of immune-responsiveness exist for PC, we explored race-based immune-profiles to identify vulnerabilities. Black men have increases in plasma cell infiltrate and associated augmented NK cell and IgG activity. These findings are associated with improved survival and nominate plasma cells as drivers of PC immune-responsiveness.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
538 Samples
Download data: CEL
Series
Accession:
GSE157547
ID:
200157547
10.

Plasma cells are enriched in localized prostate cancer in black men and are associated with improved outcomes [Discovery Cohort]

(Submitter supplied) Black men die more often of prostate cancer (PC) yet, interestingly, may derive greater survival benefits from immunotherapy. Since no signatures of immune-responsiveness exist for PC, we explored race-based immune-profiles to identify vulnerabilities. Black men have increases in plasma cell infiltrate and associated augmented NK cell and IgG activity. These findings are associated with improved survival and nominate plasma cells as drivers of PC immune-responsiveness.
Organism:
Homo sapiens
Type:
Expression profiling by array
Platform:
GPL5175
300 Samples
Download data: CEL
Series
Accession:
GSE153352
ID:
200153352
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