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Links from GEO DataSets

Items: 3

1.

Effect of high and low FGF21 expression on metabolic, inflammatory and antioxidative stress-related parameters in early lactating dairy cows

(Submitter supplied) Studies in rodent models have shown that fibroblast growth factor 21 (FGF21) is a liver-derived metabolic regulator that is induced in response to different stress conditions, such as energy and nutrient deprivation, inflammation and metabolic disorders. Recently, it has been shown that FGF21 expression in liver is dramatically induced in dairy cows during early lactation. However, the physiologically role of FGF21 in dairy cows has not been established so far. more...
Organism:
Bos taurus
Type:
Expression profiling by array
Platform:
GPL16500
16 Samples
Download data: CEL, XLSX
Series
Accession:
GSE218916
ID:
200218916
2.

Analysis of hepatic transcript profile and plasma lipid profile in early lactating dairy cows fed grape seed and grape marc meal extract

(Submitter supplied) As polyphenols are exerting a broad spectrum of metabolic effects, we hypothesize that feeding of GSGME might influence other metabolic pathways in the liver which could account for the positive effects of GSGME observed in cows during early lactation. In order to investigate this hypothesis, we used using a genome-wide transcript profiling technique to explore changes in the hepatic transcriptome of cows supplemented with GSGME during the transition period. more...
Organism:
Bos taurus
Type:
Expression profiling by array
Platform:
GPL16500
12 Samples
Download data: CEL
Series
Accession:
GSE86368
ID:
200086368
3.

Hepatic transcript profiling in early lactating dairy cows fed rumen-protected niacin during the transition from late pregnancy to lactation

(Submitter supplied) In dairy cows, administration of high dosages of niacin (NA) was found to cause anti-lipolytic effects, which are mediated by the NA receptor hydroxyl-carboxylic acid receptor 2 (HCAR2) in white adipose tissue (WAT), and thereby to an altered hepatic lipid metabolism. However, almost no attention has been paid to possible direct effects of NA in cattle liver, despite showing that HCAR2 is expressed also in the liver of cattle and is even more abundant than in WAT. more...
Organism:
Bos taurus
Type:
Expression profiling by array
Platform:
GPL16500
18 Samples
Download data: CEL
Series
Accession:
GSE116058
ID:
200116058
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