Similar studies for GEO DataSets (Select 200237251) - GEO DataSets

Select item 2002372511.

Repeated Exposure to Wood Smoke Alters Pulmonary Gene and Metabolic Profiles

(Submitter supplied) Wildfires have increased in frequency, size, and intensity in recent decades, due to increasing global temperatures and dryer climates attributable to anthropogenic climate change. Adverse respiratory effects from wildfire smoke are of specific concern for wildland firefighters who have prolonged or repeated exposure to woodsmoke. Following repeated exposure of low and high woodsmoke in rats, we performed bulk RNA sequencing on lung tissue.

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20084
23 Samples

Download data: TXT

Series

Accession:: GSE237251

ID:: 200237251

PubMed Similar studies

Select item 2001505672.

Lung response to crystalline nanocellulose exposure in rats

(Submitter supplied) Crystalline nanocellulose (CNC) is an emerging nanomaterial with multiple commercial and industrial applications. Occupational exposure to CNC during the production and/or use of products containing the nanomaterial potentially resulting in adverse health effects among workers is possible. Therefore, there is an immediate need to determine the toxicity potential of CNC. Rats were exposed to either air or CNC (20 mg/m^3, 6 hours/day, 5 days/week, 14 days) and lung toxicity was determined one day following termination of the exposures. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18694
12 Samples

Download data: CSV

Series

Accession:: GSE150567

ID:: 200150567

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000491443.

Pulmonary toxicity and global gene expression changes in response to sub-chronic inhalation exposure to crystalline silica in rats

(Submitter supplied) Occupational exposure to crystalline silica results in serious health effects, most notably, silicosis and cancer. A proper understanding of the mechanism(s) underlying the initiation and progression of silica-induced pulmonary toxicity is critical for the intervention and/or prevention of the adverse health effects associated with crystalline silica exposure. Rats were exposed to crystalline silica by inhalation at a concentration of 15 mg/m3, 6 hours/day, 5 days/week for 3, 6 or 12 weeks. more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6101
36 Samples

Download data: TXT

Series

Accession:: GSE49144

ID:: 200049144

Select item 2001097764.

Gene expression after 1 and 5 days of cigarette smoke exposure in mice with chronically inflamed or healthy lungs

(Submitter supplied) These studies tested the hypotheses that smoke induces changes in mRNA profiles that are dependent on sex and the health status of the lung, and that the effects of smoke are different after 1 day compared to 5 days of smoke exposure. The ways in which the lungs modulate their response to cigarette smoke after repeated exposures are important for understanding the toxicology of smoke, for developing biomarkers of chronic smoke exposure, and for understanding the therapeutic potential in regulatory signaling pathways that are beneficial or detrimental to lung health. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL22070
79 Samples

Download data: CEL

Series

Accession:: GSE109776

ID:: 200109776

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2002368575.

Assessment of wood smoke induced pulmonary toxicity using bronchial, chronic bronchitis-like, and alveolar lung mucosa models at air-liquid interface

(Submitter supplied) Chronic obstructive pulmonary disease (COPD) has the highest increased risk due to household air pollution arising from biomass fuel burning. However, knowledge on COPD patho-mechanisms is mainly limited to tobacco smoke exposure. In this study, a repeated direct wood smoke (WS) exposure was performed using normal- (bro-ALI) and chronic bronchitis-like bronchial (bro-ALI-CB), and alveolar (alv-ALI) lung mucosa models at air-liquid interface (ALI) to assess broad toxicological end points. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL24676
40 Samples

Download data: TXT

Series

Accession:: GSE236857

ID:: 200236857

PubMed Full text in PMC Similar studies

Select item 2001135326.

Inhaled multi-walled carbon nanotubes-induced gene expression profile in rat lung

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL22740
144 Samples

Download data: TXT

Series

Accession:: GSE113532

ID:: 200113532

Select item 2001135317.

Inhaled multi-walled carbon nanotubes-induced gene expression profile in rat lung (NM-403)

(Submitter supplied) In this work we study the pulmonary toxicological properties of carbon nanotubes using molecular toxicological approache. For this, we exposed Sprague Dawley rats by nose-only inhalation 6 hours/day, 5 days/week for 4 weeks. Lung samples have been collected up to 180 days after the end of exposure and transcriptomics analysis were performed.

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL22740
72 Samples

Download data: TXT

Series

Accession:: GSE113531

ID:: 200113531

Select item 2001135288.

Inhaled multi-walled carbon nanotubes-induced gene expression profile in rat lung (NM-401)

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL22740
72 Samples

Download data: TXT

Series

Accession:: GSE113528

ID:: 200113528

Select item 2000362089.

Transcriptomics Analysis of Lungs and Peripheral Blood of Crystalline Silica Exposed Rats

(Submitter supplied) Non-invasive or minimally invasive surrogate approaches to detect/predict target organ toxicity have significant practical applications in occupational toxicology. Presently, using a rat model, we have investigated the potential application of peripheral blood transcriptomics as a practical approach to study the mechanisms of silica-induced pulmonary toxicity. Rats were exposed by inhalation to crystalline silica for one week (15 mg/m3, 6-hours/day, 5 days/week). more...

Organism:: Rattus norvegicus

Type:: Expression profiling by array

Platform:: GPL6101
24 Samples

Download data: TXT

Series

Accession:: GSE36208

ID:: 200036208

PubMed Full text in PMC Similar studies Analyze with GEO2R

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