GEO DataSets

(Submitter supplied) Two matched groups of Heart Failure with reduced ejection fraction patients with no peripheral venous congestion were studied: with recent prior heart failure hospitalization vs. without recent heart failure hospitalization. Peripheral venous congestion was modeled by inflating a cuff around the dominant arm, targeting an ~30mmHg increase in venous pressure (venous stress test). Blood and endothelial cells were sampled before and after 90 minutes of venous stress test.

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing

Platform:

GPL570

46 Samples

Download data: CEL

(Submitter supplied) Background: Venous hypertension is often present in advanced and in acute decompensated heart failure (HF). However, it is unclear whether high intravenous pressure can cause alterations in homeostasis by promoting inflammation and endothelial cell (EC) activation. We used an experimental model of acute, local venous hypertension to study the changes in circulating inflammatory mediators and EC phenotype that occur in response to biomechanical stress. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS4773

Platform:

GPL570

24 Samples

Download data: CEL

Analysis of venous endothelial cells (EC) following experimental venous hypertension treatment, a venous stress test designed to model peripheral venous congestion. Results provide insight into the molecular consequences of peripheral acute venous congestion in ECs.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 12 individual, 2 protocol sets

Platform:

GPL570

Series:

GSE38783

24 Samples

Download data: CEL

(Submitter supplied) Plasma miRNAs associated with LVRR in humans are dysregulated in animal HF and target clusters of genes involved in mechanisms implicated in HF. A translational approach integrating human HF, bioinformatics, and model systems may uncover novel pathways involved in HF.

Organism:

Homo sapiens

Type:

Non-coding RNA profiling by array

Platform:

GPL24497

64 Samples

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