Similar studies for GEO DataSets (Select 200271848) - GEO DataSets

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Items: 5

Select item 2002718481.

Aged vascular niche hinders osteogenesis of mesenchymal stem cells through paracrine repression of Wnt-axis

(Submitter supplied) Age-induced decline in osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) potentiates osteoporosis and increases risk for bone fractures. Despite epidemiology studies reporting concurrent development of vascular- and bone diseases in the elderly, the underlying mechanisms for the vascular-bone cross-talk in aging are largely unknown. In this study, we show that accelerated endothelial aging deteriorates bone tissue through paracrine repression of Wnt-driven-axis in BMSCs. more...

Organism:: Homo sapiens

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL11154
6 Samples

Download data: CSV

Series

Accession:: GSE271848

ID:: 200271848

PubMed Full text in PMC Similar studies

Select item 2002721952.

Endothelial and systemic upregulation of miR-34a-5p fine-tunes senescence in progeria

(Submitter supplied) Endothelial defects significantly contribute to cardiovascular pathology in the premature aging disease Hutchinson-Gilford progeria syndrome (HGPS). Using an endothelium-specific progeria mouse model, we identify a novel, endothelium-specific microRNA (miR) signature linked to the p53-senescence pathway and a senescence-associated secretory phenotype (SASP). Progerin-expressing endothelial cells exert profound cell-non-autonomous effects initiating senescence in non-endothelial cell populations and causing immune cell infiltrates around blood vessels. more...

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platform:: GPL13112
36 Samples

Download data: XLSX

Series

Accession:: GSE272195

ID:: 200272195

PubMed Full text in PMC Similar studies

Select item 2001662443.

NAP1L2 Drives Mesenchymal Stem Cell Senescence and Suppresses Osteogenic Differentiation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL23479 GPL21273
12 Samples

Download data: BW, NARROWPEAK

Series

Accession:: GSE166244

ID:: 200166244

PubMed Full text in PMC Similar studies

Select item 2001662434.

NAP1L2 Drives Mesenchymal Stem Cell Senescence and Suppresses Osteogenic Differentiation [RNA-Seq]

(Submitter supplied) Changes in these genes are probably a consequence of aging, and the real regulators governing BMSC senescence and osteogenesis are still unclear.In the current study, we report that nucleosome assembly-related protein NAP1L2 serves as an important regulator of both the senescence and osteogenic differentiation of BMSCs through inhibition of NF-κB signaling and recruitment of SIRT1 to deacetylate the H3K14ac level on promoters of osteogenic genes. more...