GEO DataSets

Analysis of umbilical vein endothelial cells 1 and 6 hours following infection with adherent wild type or the non-adherent (delta pilD) mutant form of Neisseria meningitidis. Results provide insight into the role of adherence-mediated signaling in N. meningitidis infections.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 3 infection, 2 time sets

Platform:

GPL96

Series:

GSE4646

12 Samples

Download data: CEL

(Submitter supplied) We examined the adherence-mediated signaling of meningococci to human cells by comparing gene expression profiles of primary human umbilical vein endothelial cells (HUVEC) infected by piliated and adherent wild-type (WT), frpC/frpA-deficient mutant, or the non-adherent (ΔpilD) N. meningitidis MC58 bacteria defective in production of the type IV pilus, respectively. Surprisingly, no significant difference was found between the transcriptomes of HUVECs infected by bacteria producing, or not the RTX FrpC and FrpA proteins, thus failing to provide any hints on their biological activity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS2332 GDS2333

Platform:

GPL96

23 Samples

Download data: CEL, ZIP

Analysis of umbilical vein endothelial cells 4 hours following infection with adherent wild type, frpC-deficient mutant, or the non-adherent (delta pilD) mutant form of Neisseria meningitidis. Results provide insight into the role of adherence-mediated signaling in N. meningitidis infections.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 4 infection sets

Platform:

GPL96

Series:

GSE4646

11 Samples

Download data: CEL

(Submitter supplied) Kallikrein-related peptidase 3 (KLK3, also known as prostate-specific antigen, PSA) is a chymotrypsin-like kallikrein that has been shown to have anti-angiogenic properties. KLK3 expression in prostate cancer is associated with low microvessel density. We have previously shown in a human umbilical vein endothelial cell (HUVEC) model that the anti-angiogenic effect of KLK3 is related to its enzymatic activity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL4133

3 Samples

Download data