GEO DataSets

Analysis of resting Jurkat T cells and derived mutants lacking T cell receptor (TCR) signaling proteins. Even without TCR engagement, the signaling pathways normally responsive to TCR are not inert. Results provide insight into the transcriptional consequences of the constitutive signaling pathway.

Organism:

Homo sapiens

Type:

Expression profiling by array, log2 ratio, 6 cell line, 2 genotype/variation, 2 protocol sets

Platform:

GPL3084

Series:

GSE3922

21 Samples

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(Submitter supplied) Signal transduction pathways guided by cellular receptors commonly exhibit low-level constitutive signaling in a continuous, ligand-independent manner. The dynamic equilibrium of positive and negative regulators establishes such a tonic signal. Ligandindependent signaling by the precursors of mature antigen receptors regulates development of B- and T-lymphocytes. Here we describe a basal signal controlling gene expression profiles in the Jurkat T cell line and mouse thymocytes. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2352

Platform:

GPL3084

21 Samples

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(Submitter supplied) Foxo1 is required for proper developmental progression due to distinct functions at different stages of B cell development, but specific gene targets in pro-B cells are not identified. We performed a microarray analysis in v-Abl transformed pro-B cells to compare the gene expression pattern between wildtype and Foxo1 knockout cells.

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

6 Samples

Download data: CEL

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Homo sapiens

Type:

Expression profiling by array

Platforms:

GPL571 GPL96

20 Samples

Download data: CEL

(Submitter supplied) MCF10A cells derived from spontaneously immortalized normal human mammary epithel were subjected to EGF/SERUM stimulation for 0,20,40,60,120,240 and 480 minutes. We used microarrays to understand the temporal regulation of the cellular EGFR cascade. Keywords: time course

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2622

Platform:

GPL571

13 Samples

Download data: CEL

(Submitter supplied) HELA cells derived from human cervical tumor were subjected to EGF stimulation for 0,20,40,60,120,240 and 480 minutes. We used microarrays to understand the temporal regulation of the cellular EGFR cascade. Keywords: time course

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2623

Platform:

GPL96

7 Samples

Download data: CEL

Analysis of cervical carcinoma HeLa cells following treatment with epidermal growth factor for various time points up to 480 minutes. Results provide insight into the dynamics of growth factor signaling.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 7 time sets

Platform:

GPL96

Series:

GSE6783

7 Samples

Download data: CEL

Analysis of mammary epithelial MCF10A cells following treatment with epidermal growth factor for various time points up to 480 minutes. Results provide insight into the dynamics of growth factor signaling.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 7 time sets

Platform:

GPL571

Series:

GSE6784

13 Samples

Download data: CEL