Similar studies for GEO DataSets (Select 2649) - GEO DataSets

Select item 26491.

HIV infection effect on CD4+ and CD8+ T cells

Analysis of CD4+ and CD8+ T cells from HIV patients at different clinical stages and rates of disease progression. Changes in T-cell function are a hallmark of HIV infection. Results provide insight into the pathogenic mechanisms in HIV infections that lead to these changes in T-cell function.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 cell type, 4 disease state sets

Platform:: GPL96
Series:: GSE6740
40 Samples

Download data: CEL

DataSet

Accession:: GDS2649

ID:: 2649

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000067402.

Comparison of transcriptional profiles of CD4+ and CD8+ T cells from HIV-infected pateints and uninfected control group

(Submitter supplied) We examined the gene expression profiles in ex vivo human CD4+ and CD8+ T cells from untreated HIV-infected individuals at different clinical stages and rates of disease progression. Profiles of pure CD4+ and CD8+ T cells subsets from HIV-infected nonprogressors who controlled viremia were indistinguishable from HIV-uninfected individuals. Similarly, no gene clusters could distinguish T cells from individuals with early from chronic progressive HIV infection, whereas differences were observed between uninfected or nonprogressors versus early or chronic progressors. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS2649
Platform:: GPL96
40 Samples

Download data: CEL

Series

Accession:: GSE6740

ID:: 200006740

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000281283.

Comparative analysis of genomic features of human HIV-1 infection and primate models of SIV infection

(Submitter supplied) High levels of HIV-1 replication during the chronic phase of infection are usually associated with rapid disease progression (RP). However, a minority of HIV-infected individuals remain asymptomatic and show persistently high CD4+ T cell counts despite high viremia for many years (viremic non progressors, VNP). The latter profile is reminiscent of the non-pathogenic model of SIV infection in natural hosts such as the sooty mangabey. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL6884
79 Samples

Download data: TXT

Series

Accession:: GSE28128

ID:: 200028128

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000099274.

Chronic CD4+ T cell Activation & Depletion in HIV-1 Infection: Type I Interferon-Mediated Disruption of T Cell Dynamics

(Submitter supplied) The mechanism of CD4(+) T cell depletion during chronic human immunodeficiency virus type 1 (HIV-1) infection remains unknown. Many studies suggest a significant role for chronic CD4(+) T cell activation. We assumed that the pathogenic process of excessive CD4(+) T cell activation would be reflected in the transcriptional profiles of activated CD4(+) T cells. Here we demonstrate that the transcriptional programs of in vivo activated CD4(+) T cells from untreated HIV(+) individuals are clearly different from those activated CD4(+) T cells from HIV(-) individuals. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
20 Samples

Download data: CEL

Series

Accession:: GSE9927

ID:: 200009927

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000254565.

CD8+ and CD4+ T cells from HIV infected patients with HIV-RNA viremia

(Submitter supplied) CD8+ and CD4+ T cells from HIV infected patients with HIV-RNA viremia of >50 copies/ml and CD8+ and CD4+ T cells from healthy controls were isolated by negative selection (Miltenyi Biotech, Auburn, CA). Cell sorting of the CD4 and CD8 T cell subsets were performed based on surface staining of CD3+CD8+ or CD3+CD4+ and na ve CD45RA+CD27+CD127highHLA-DRlow, and CD3+CD8+ or CD3+CD4+ and memory CD45RA-CD27+CD127highHLA-DRlow. more...

Organism:: Homo sapiens

Type:: Expression profiling by RT-PCR

Platform:: GPL11225
31 Samples

Download data: TXT

Series

Accession:: GSE25456

ID:: 200025456

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001578296.

An Atlas of Immune Cell Exhaustion in HIV-Infected Individuals Revealed by Single-Cell Transcriptomics

(Submitter supplied) We investigated the effects of HIV infection on immune cell exhaustion at the transcriptomic level by analyzing single-cell RNA sequencing of peripheral blood mononuclear cells from four healthy subjects (37,847 cells) and six HIV-infected donors (28,610 cells). We identified nine immune cell clusters and eight T cell subclusters according to their unique gene expression programs; three of these (exhausted CD4+ and CD8+ T cells and interferon-responsive CD8+ T cells) were detected only in samples from HIV-infected donors. more...

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL16791
7 Samples

Download data: MTX, TSV

Series

Accession:: GSE157829

ID:: 200157829

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000937127.

Comparison of gene expression profiles of HCV-specific CD8 T cells from resolving patients and HCV-specific CD8 T cells chronic patients that target conserved or escaped epitopes.

(Submitter supplied) T cell exhaustion is a well-defined process diminishing the efficacy of the CD8 response in persistent viremia. What is less understood is whether early differences in T cell regulation already predetermine the fate of the T cell response and infection outcome. Its dichotomous outcome that is unique among human viral infections makes hepatitis C virus infection uniquely suited to compare transcriptional regulation between HCV-specific CD8 T cells that do and do not achieve viral control. more...