Similar studies for GEO DataSets (Select 2734) - GEO DataSets

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Items: 20

Select item 27341.

DNA-associated protein Stonewall deficiency effect on ovaries

Comparison of ovaries from bag of marbles (bam) mutants and stonewall (stwl) bam double mutants. Stwl is a DNA-associated protein required for germline stem cell (GSC) maintenance; Bam is a key differentiation factor. Results provide insight into the role of Stwl in maintaining germ cell identity.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL1322
Series:: GSE6928
6 Samples

Download data: CEL

DataSet

Accession:: GDS2734

ID:: 2734

Select item 2000069282.

Stonewalling Drosophila stem cell differentiation by epigenetic controls

(Submitter supplied) Abstract: During Drosophila oogenesis, germline stem cell (GSC) identity is maintained largely by preventing the expression of factors that promote differentiation. This is accomplished via the activity of several genes acting either in the GSC or its niche. The translational repressors, Nanos and Pumilio, act in GSCs to prevent differentiation, likely by inhibiting translation of early differentiation factors, while niche signals prevent differentiation by silencing transcription of the differentiation factor Bam. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS2734
Platform:: GPL1322
6 Samples

Download data: CEL

Series

Accession:: GSE6928

ID:: 200006928

Select item 2002689433.

Effect of overexpession of Stonewall (Stwl) on gene expression in germline stem cell (GSC)-like cells compared to the control

(Submitter supplied) The association of genomic loci to the nuclear periphery is proposed to facilitate cell type-specific gene repression and influence cell fate decisions. However, the interplay between gene position and expression remains incompletely understood, in part because the proteins that position genomic loci at the nuclear periphery remain unidentified. Here, we used an Oligopaint-based HiDRO screen targeting ∼1000 genes to discover novel regulators of nuclear architecture in Drosophila cells.We identified the heterochromatin-associated protein Stonewall (Stwl) as a factor promoting perinuclear chromatin positioning. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25244
8 Samples

Download data: TXT

Series

Accession:: GSE268943

ID:: 200268943

PubMed Full text in PMC Similar studies

Select item 2002677324.

Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis [RNA-Seq2]

(Submitter supplied) Genome organization can regulate gene expression and promote cell fate transitions. The differentiation of germline stem cells (GSCs) to oocytes in Drosophila involves changes in genome organization mediated by heterochromatin and the nuclear pore complex (NPC). Heterochromatin represses germ-cell genes during differentiation and NPCs anchor these silenced genes to the nuclear periphery, maintaining silencing to allow for oocyte development. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19132
5 Samples

Download data: CSV

Series

Accession:: GSE267732

ID:: 200267732

PubMed Full text in PMC Similar studies

Select item 2002503515.

Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL25244 GPL19132
37 Samples

Download data: BED, BW

Series

Accession:: GSE250351

ID:: 200250351

PubMed Full text in PMC Similar studies

Select item 2002503506.

Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis [CUT&RUN]

(Submitter supplied) Genome organization can regulate gene expression and promote cell fate transitions. The differentiation of germline stem cells (GSCs) to oocytes in Drosophila involves changes in Genome organization mediated by heterochromatin and the nuclear pore complex (NPC). Heterochromatin represses germ-cell genes during differentiation and NPCs anchor these silenced genes to the nuclear periphery, maintaining silencing to allow for oocyte development. more...

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL25244
24 Samples

Download data: BED, BW

Series

Accession:: GSE250350

ID:: 200250350

PubMed Full text in PMC Similar studies

Select item 2002480577.

Genome organization regulates nuclear pore complex formation and promotes differentiation during Drosophila oogenesis [RNA-seq]

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19132
8 Samples

Download data: CSV

Series

Accession:: GSE248057

ID:: 200248057

PubMed Full text in PMC Similar studies

Select item 2000659328.

Next Generation Sequencing Facilitates Quantitative Analysis of Wild Type and snf[148] ovary Transcriptomes

(Submitter supplied) Comparison of wild type and tumorous ovaries reveals that tumors inappropriately express a large number of testis genes

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL17275
4 Samples

Download data: TXT

Series

Accession:: GSE65932

ID:: 200065932

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000967519.

Aubergine Controls Germline Stem Cell Self-Renewal and Progeny Differentiation via Distinct Mechanisms

(Submitter supplied) Purpose: Piwi family protein Aubergine (Aub) maintains genome integrity in late germ cells of the Drosophila ovary through piRNA-mediated repression of transposon activities. Although it is highly expressed in germline stem cells (GSCs) and early progeny, it remains unclear if it plays any roles in early GSC lineage development. Results: The study reveals a novel function of Aub in GSCs and their progeny, which promotes translation of self-renewal and differentiation factors by directly binding to its target mRNAs and interacting with translational initiation factors.

Organism:: Drosophila melanogaster

Type:: Other

Platform:: GPL17275
3 Samples

Download data: BED

Series

Accession:: GSE96751

ID:: 200096751

PubMed Similar studies SRA Run Selector

Select item 20022994310.

Chromatin and gene expression changes during female Drosophila germline stem cell development.

(Submitter supplied) The maintenance and differentiation of highly potent animal stem cells generates an epigenetic cycle that underlies development. Drosophila female germline stem cells (GSC) produce cystoblast daughters that differentiate into nurse cells and oocytes. Developmental chromatin analysis profiling the differentiation of GSCs into cystoblasts and NCs of increasing ploidy shows that cystoblasts start developing by forming heterochromatin while in a transient syncytial state, the germline cyst, reminiscent of early embryonic cells. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Third-party reanalysis

Platform:: GPL19132
28 Samples

Download data: BEDGRAPH, BW, CSV, TXT

Series

Accession:: GSE229943

ID:: 200229943

PubMed Full text in PMC Similar studies

Select item 20014283011.

microRNA expression analysis in fly ovaries from wuho and mei-p26 mutants

(Submitter supplied) Purpose: The goal of this study is to analyze microRNA affected by wuho and mei-p26 mutations in Drosophila ovary Ovarian microRNA prolife of 7 day old control flies and flies bearing wuho and mei-p26 mutations, in duplicate.Sample libraries were prepared using the QIAseq miRNA Library Kit (QIAGEN) according to the manufacturer's protocols. Adaptors are ligated sequentially to the 3' and 5' ends of miRNAs. more...

Organism:: Drosophila melanogaster

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL19132
6 Samples

Download data: XLSX

Series

Accession:: GSE142830

ID:: 200142830

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014282912.

Gene expression analysis in fly ovaries from wuho mutant

(Submitter supplied) Purpose: The goal of this study is to analyze genes affected by wuho mutation in Drosophila ovary Ovarian mRNA prolife of 7 day old control flies and flies bearing wuho mutation, in duplicate, using Illumina NextSeq 500. The sequence reads that passed quality filters were analyzed at the transcript isoform level with two methods: Burrows–Wheeler Aligner (BWA) followed by ANOVA (ANOVA) and TopHat followed by Cufflinks.

Organism:: Drosophila melanogaster

Type:: Expression profiling by high throughput sequencing

Platform:: GPL19132
4 Samples

Download data: XLSX

Series

Accession:: GSE142829

ID:: 200142829

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20007808013.

Expression data from bam and setdb1 mutant ovaries

(Submitter supplied) Germline stem cell self-renewal and differentiation are required for sustained production of gamates. GSC differentiation in drosophila requires expression of setdb1 by the somatic niche, however its function is not known. We used microarray analysis to determine what genes does setdb1 regulate to affect differentiation.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL1322
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE78080

ID:: 200078080

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20002268614.

Expression analysis of laser cut germaria vs laser cut apex of testes

(Submitter supplied) Here we used laser cutting microdissection and RNA amplification to profile the gene expression in wildtype female germaria and male apex of the testes. These tissue contain germline stem cells and early dividing germ cells. Our goal was to identify genes expressed in these cell types.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL3880
4 Samples

Download data: GPR

Series

Accession:: GSE22686

ID:: 200022686

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20009382815.

E(Pc) ChIP-seq experiment in fruitfly testis somatic gonadal cells and RNA-seq experiment in fruitfly testis

(Submitter supplied) With the ChIP-seq experiment, we identified direct target genes of E(Pc) specifically in somatic gonadal cells. We found that the E(Pc)-binding genes are enriched with signaling pathway components, consistent with our functional data showing prevailing germline defects even when E(Pc) function is exclusively compromised in somatic gonadal cells. In addition, we also performed RNA-seq to compare transcriptomes between E(Pc) knockdown testes and control testes.

Organism:: Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL16479 GPL17275
8 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE93828

ID:: 200093828

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009530916.

Gene expression analyses in otefin mutant Drosophila ovaries

(Submitter supplied) LEM Domain proteins are key components of the nuclear lamina. Mutations in LEM-D proteins cause dystrophic diseases associated with compromised adult stem cells, yet it remains unclear how LEM-D proteins support stem cell function. Studies described here use the homologue of the LEM-D protein emerin in Drosophila, Otefin (Ote) as a model to understand LEM-D protein function in adult stem cells. Loss of Ote causes female sterility due to a complex germline stem cell (GSC) phenotype that includes both an early block in germline differentiation followed by GSC death. more...

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Platform:: GPL1322
8 Samples

Download data: CEL

Series

Accession:: GSE95309

ID:: 200095309

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20000278417.

GSC differentiation-reversion test

(Submitter supplied) gene expression is tested for an association with GSCs by comparing expression levels in ovary tips of c587-GAL4; hs-bam UAS-dpp females at 0 hr, 20 hr and 50 hr after heat shock ; results of two independent experiments are given as expt 1 and expt 2 Keywords: time course, heat shock, bam overexpression

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS1906
Platform:: GPL72
6 Samples

Download data

Series

Accession:: GSE2784

ID:: 200002784

Select item 20000278318.

GSC vs Kc

(Submitter supplied) This series compares gene expression between germ line stem cells (GSCs) purified either from bam mutant or Dpp-overexpressing ovaries, with gene expression in Kc cells Keywords: bam mutant, Dpp overexpression

Organism:: Drosophila melanogaster

Type:: Expression profiling by array

Dataset:: GDS1905
Platform:: GPL72
9 Samples

Download data

Series

Accession:: GSE2783

ID:: 200002783

Select item 190619.

Ovarian germ line stem cell differentiation and reversion: time course

Analysis of Dpp expanded germ line stem cells (GSCs) at various time points up to 50 hours following transient bam gene induction. GSCs differentiate into cystocytes 20 hours following bam induction. Cystocytes revert to GSCs 30 hours later. Results identify candidate GSC-specific genes.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array, count, 2 cell type, 2 protocol, 3 time sets

Platform:: GPL72
Series:: GSE2784
6 Samples

Download data

DataSet

Accession:: GDS1906

ID:: 1906

Select item 190520.

Ovarian germ line stem cells expanded by Dpp overexpression and bam mutation

Analysis of purified ovarian germ line stem cells (GSCs) expanded by overexpression of the bone morphogenetic protein Dpp or by mutating the bam gene. Kc tissue culture cells also examined. Dpp represses bam transcription. Results provide insight into the mechanisms of GSC maintenance and function.

Organism:: Drosophila melanogaster

Type:: Expression profiling by array, count, 2 cell type, 3 genotype/variation sets

Platform:: GPL72
Series:: GSE2783
9 Samples

Download data

DataSet

Accession:: GDS1905

ID:: 1905

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