GEO DataSets

Analysis of malignant ovarian cancer tumors from patients receiving neo-adjuvant chemotherapy. Ovarian adenomas and untreated ovarian carcinomas also examined. Results used to define gene expression signatures associated with clinical responses to chemotherapy.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 disease state, 2 protocol sets

Platform:

GPL8300

Series:

GSE7463

43 Samples

Download data: CEL

(Submitter supplied) Gene expression profiles of malignant carcinomas surgically removed from ovarian cancer patients pre-treated with chemotherapy (neo-adjuvant) prior to surgery group into two distinct clusters. One group clusters with carcinomas from patients not pre-treated with chemotherapy prior to surgery (C-L) while the other clusters with non-malignant adenomas (A-L). Although the C-L cluster is preferentially associated with p53 loss-of-function (LOF) mutations, the C-L cluster cancer patients display a more favorable clinical response to chemotherapy as evidenced by enhanced long-term survivorships. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2785

Platform:

GPL8300

43 Samples

Download data: CEL

(Submitter supplied) Twenty three small-cell lung carcinoma (SCLC) cell lines from ATCC profiled on 100K genotyping arrays Keywords: comparative genomic hybridization

Organism:

Homo sapiens

Type:

Genome variation profiling by SNP array; SNP genotyping by SNP array

Platforms:

GPL2004 GPL2005

23 Samples

Download data: CEL, CHP

(Submitter supplied) Several studies described a role for the E2F/Rb pathway in ovarian serous carcinomas (SCAs). Since E2F/Rb pathway deregulation is a general hallmark of human cancer, it remains unclear whether this deregulation is of particular importance in SCAs or whether it reflects a common oncologic feature. Here, we attempted to clarify this issue by the examination of microarray expression profiles of SCAs (10 SCA1s, 15 SCA3s) and particularly by the comparison with another, less malignant, ovarian cancer type, serous borderline tumours (13 SBTs). more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL201

39 Samples

Download data: CEL