GEO DataSets

Analysis of leukocytes from individuals before and after the administration of granulocyte colony-stimulating factor (G-CSF). G-CSF is used to boost granulocyte counts in immunocompromised patients. Results provide insight into the effect of G-CSF on the immune system.

Organism:

Homo sapiens

Type:

Expression profiling by array, count, 2 agent, 5 individual sets

Platform:

GPL570

Series:

GSE7400

10 Samples

Download data: CEL

(Submitter supplied) Granulocyte-colony stimulating factor (G-CSF) is used to boost granulocyte counts in immunocompromised patients, but its effects on the immune system may be counter productive. We tested the hypothesis that G-CSF mobilized peripheral blood stem cell (PBSC) products are immunologically down regulated based on gene microarray analysis. Ten peripheral blood samples from normal donors for allogeneic PBSC transplantation were obtained before and after administration of G-CSF and tested on Affymetrix Human U133 Plus 2.0 GeneChip® microarrays. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2959

Platform:

GPL570

10 Samples

Download data: CEL

(Submitter supplied) Peripheral blood stem and progenitor cells (PBSC) are widely used for autologous and allogeneic hematopoietic stem cell transplantation. PBSC can be mobilized into the peripheral blood using cytokines, cytotoxic chemotherapy or a combination of both. Granulocyte colony stimulating factor (G-CSF) has become the most commonly administered cytokine for PBSC mobilization because of its high potency and lack of serious toxicity. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS2321

Platform:

GPL201

16 Samples

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Analysis of granulocyte colony stimulating factor (G-CSF) or polyethylene glycol-conjugated (pegylated) G-CSF mobilized CD34+ hematopoietic stem and progenitor cells from multiple myeloma patients undergoing chemotherapy. Pegylated G-CSF has a longer half-life than unconjugated G-CSF.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 agent sets

Platform:

GPL201

Series:

GSE4688

16 Samples

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(Submitter supplied) The purpose of this study was to search for microgravity-sensitive genes, specifically for apoptotic genes influenced by the microgravity environment and other genes related to immune response. Keywords: stress response

Organism:

Homo sapiens

Type:

Expression profiling by array

Dataset:

GDS1806

Platform:

GPL96

6 Samples

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Analysis of activated T-cells subjected to modeled microgravity. The study seeks to identify microgravity sensitive genes involved in apoptosis and the immune response. Microgravity is an environment of little net gravitational force that is experienced in spaceflight and by free-falling objects.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 2 protocol sets

Platform:

GPL96

Series:

GSE4209

6 Samples

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(Submitter supplied) Three innate (B1-B, NKT, CD8aaT cells) and adaptive (B2-B, CD4T, CD8abT cells) cell-types were sorted by FACS. Three biological replicates for NKT, CD4T, CD8aaT, CD8abT cells and two biological replicates for B1 and B2 cells were generated and the expression profiles were determined using Affymetrix Mu74Av2 chip. Comparisons between the sample groups allow the identification of genes differentially expressed between the innate and adaptive cell-types. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL81

16 Samples

Download data: CEL

(Submitter supplied) This study investigated gene expression changes in whole blood samples obtained from donors diagnosed with major depressive disorder (MDD) compared to healthy controls. Micro-array data were available from whole blood on patients with MDD (N=128, 64 with generalised anxiety disorder, diagnosed by the MINI questionnaire, and 64 without anxiety disorder) and healthy controls (N=64). RNA was isolated from all samples using the standard PAXgene protocol on the Qiagen Biorobot 8000. more...

Organism:

Homo sapiens

Type:

Expression profiling by array

Platform:

GPL570

192 Samples

Download data: CEL