GEO DataSets

Analysis of livers of Wistar animals during a 24-hour period, from zeitgeber time (ZT) 0.25 to ZT 23.75. Results provide insight into baseline patterns of gene expression in normal liver within the 24 hour circadian cycle.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 18 time sets

Platform:

GPL341

Series:

GSE8988

54 Samples

Download data: CEL

(Submitter supplied) In intact animals, time of drug administration may be an important factor influencing drug response. Our general goal seeks to incorporate circadian time into the study of corticosteroid regulated gene expression. Since levels of endogenous steroid exhibit circadian fluctuations, it is our hypothesis that the expression of genes controlled by corticosteroids either directly or indirectly, will also exhibit a circadian pattern in normal animals. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3084

Platform:

GPL341

54 Samples

Download data: CEL

(Submitter supplied) Circadian rhythms are oscillations with a periodicity of 24 hours that are controlled by an endogenous clock and are observed in virtually all aspects of mammalian function from expression of genes to complex physiological processes. The master clock is present in the suprachiasmatic nucleus (SCN) in the anterior part of the hypothalamus and controls peripheral clocks present in other parts of the body . more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

54 Samples

Download data: CEL, CHP

(Submitter supplied) Circadian rhythms are oscillations with a periodicity of 24 hours that are controlled by an endogenous clock and are observed in virtually all aspects of mammalian function from expression of genes to complex physiological processes. The master clock is present in the suprachiasmatic nucleus (SCN) in the anterior part of the hypothalamus and controls peripheral clocks present in other parts of the body. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Platform:

GPL1355

52 Samples

Download data: CEL, CHP

(Submitter supplied) In intact animals, time of drug administration may be an important factor influencing drug response. Our general goal seeks to incorporate circadian time into the study of corticosteroid regulated gene expression. This study is designed to examine fluctuations in gene expression in skeletal muscle within the 24 hour circadian cycle in normal animals. Circadian time is relevant to designing optimal corticosteroid dosing regimens. more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3083

Platform:

GPL341

54 Samples

Download data: CEL

Analysis of gastrocnemius muscles of Wistar animals during a 24-hour period, from zeitgeber time (ZT) 0.25 to ZT 23.75. Results provide insight into baseline patterns of gene expression in normal skeletal muscle within the 24 hour circadian cycle.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 18 time sets

Platform:

GPL341

Series:

GSE8989

54 Samples

Download data: CEL

(Submitter supplied) Mammalian gene expression displays widespread circadian oscillations. Rhythmic transcription underlies the core clock mechanism, but it cannot explain numerous observations made at the level of protein rhythmicity. We have used ribosome profiling in mouse liver to measure the translation of mRNAs into protein around-the-clock and at high temporal and nucleotide resolution. Transcriptome-wide, we discovered extensive rhythms in ribosome occupancy, and identified a core set of ≈150 mRNAs subject to particularly robust daily changes in translation efficiency. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL17021

48 Samples

Download data: TXT

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platforms:

GPL21103 GPL13112

12 Samples

Download data

(Submitter supplied) Purpose: Identifying the biological pathways affected by the deletion of the zona pellucida binding protein 2 in mouse lungs at different time points Method: RNA profiles of wild type C57BL6/J mice and Zpbp2 homozygous knock-out lungs were generated using next generation sequencing Illumina HiSeq4000 PE100

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

6 Samples

Download data: CSV

(Submitter supplied) Purpose: Identifying the biological pathways affected by the deletion of the zona pellucida binding protein 2 in mouse lungs at different time points Method: RNA profiles of wild type C57BL6/J mice and Zpbp2 homozygous knock-out lungs were generated using next generation sequencing Illumina HiSeq2000 SR50

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL13112

6 Samples

Download data: CSV

(Submitter supplied) Circadian clocks exist in almost all levels of living organisms and play elementary roles in the persistence of regular physiological and behavioural processes. Canonical transcription/translation feedback loop models portray BMAL1 (ARNTL) as one of the principal drivers of circadian periodicity in mammalian systems. In this integrated multi-omics study, we demonstrate, for the first time, 24 hr circadian oscillations in the expression levels of several transcripts and proteins in dexamethasone-synchronized Bmal1-/- mouse fibroblast cells and liver tissue slices. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

212 Samples

Download data: TXT

(Submitter supplied) Circadian clocks exist in almost all levels of living organisms and play elementary roles in the persistence of regular physiological and behavioural processes. Canonical transcription/translation feedback loop models portray BMAL1 (ARNTL) as one of the principal drivers of circadian periodicity in mammalian systems. In this integrated multi-omics study, we demonstrate, for the first time, 24 hr circadian oscillations in the expression levels of several transcripts and proteins in dexamethasone-synchronized Bmal1-/- mouse fibroblast cells and liver tissue slices. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL21103

336 Samples

Download data: TXT

(Submitter supplied) The liver circadian clock is reprogrammed by nutritional challenge through the rewiring of specific transcriptional pathways. As the gut microbiota is tightly connected to host metabolism, whose coordination is governed by the circadian clock, we explored whether gut microbes influence circadian homeostasis and how they distally control the peripheral clock in the liver. Using fecal transplant procedures we reveal that, in response to high fat diet, the gut microbiota drives PPARγ-mediated activation of newly oscillatory transcriptional programs in the liver. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

48 Samples

Download data: CEL, XLS

(Submitter supplied) Circadian and metabolic processes are codependent. This experiment was designed to understand how a high fat diet affects circadian gene expression in the liver. Circadian gene expression in the liver is necessary for energy balance.

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4783

Platform:

GPL6246

36 Samples

Download data: CEL, CHP

Analysis of livers of C57BL/6J animals after 10 weeks on a high fat diet (HFD). Livers were harvested every 4 hours up to Zeitgeber time 20. Circadian rhythms and cellular metabolism are intimately linked. Results provide insight into the molecular effect of HFD on the circadian clock.

Organism:

Mus musculus

Type:

Expression profiling by array, count, 2 protocol, 6 time sets

Platform:

GPL6246

Series:

GSE52333

36 Samples

Download data: CEL, CHP

(Submitter supplied) The circadian clock orchestrates rhythms in physiology and behavior, allowing the organism to adapt to daily environmental changes. Recently, efforts have been made to unravel the connection between the circadian clock and metabolism and to understand how the peripheral clock in different organs coordinates circadian responses to maintain metabolic homeostasis. It is becoming clear that diet can influence diurnal rhythms, however, the molecular mechanisms responsible for alterations in daily oscillations and how tissue-specific clocks interpret a nutritional challenge are not well understood. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL6246

72 Samples

Download data: CEL, CHP, XLS

(Submitter supplied) Physiological and behavioral circadian rhythms are driven by a conserved transcriptional/translational negative feedback loop in mammals. Although most core clock factors are transcription factors, post-transcriptional control introduces delays that are critical for circadian oscillations. Little work has been done on circadian regulation of translation, so to address this deficit we conducted ribosome profiling experiments in a human cell model for an autonomous clock. more...

Organism:

Homo sapiens

Type:

Expression profiling by high throughput sequencing; Other

Platform:

GPL11154

96 Samples

Download data: TXT

(Submitter supplied) Virtually every mammalian tissue exhibits rhythmic expression in thousands of genes, which activate tissue-specific processes at appropriate times of the day. Much of this rhythmic expression is thought to be driven cell-autonomously by molecular circadian clocks present throughout the body. However, increasing evidence suggests that systemic signals, and more specifically rhythmic food intake (RFI), can regulate rhythmic gene expression independently of the circadian clock. more...

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL19057

72 Samples

Download data: TXT

(Submitter supplied) RNAseq transcriptional profiling of Drosophila heads from Achilles RNAi or control animals

Organism:

Drosophila melanogaster

Type:

Expression profiling by high throughput sequencing

Platform:

GPL16479

14 Samples

Download data: TXT, XLSX

(Submitter supplied) Transcription factors may orchestrate the health benefits of intermittent fasting through directing the expression of genome. Here, we find intermittent fasting can spin the spatiotemporal profile of transcription factors, and provide an atlas of transcription factors in biological space, time and feeding regimen.

Organism:

Mus musculus

Type:

Expression profiling by high throughput sequencing

Platform:

GPL24247

600 Samples

Download data: FA, TXT