Similar studies for GEO DataSets (Select 3192) - GEO DataSets

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Items: 5

Select item 31921.

Rheumatoid arthritis: synovial macrophages

Analysis of synovial fluid macrophages from 5 patients with rheumatoid arthritis (RA). The chronic inflammation and progressive joint destruction observed in RA are mediated in part by macrophages. Results provide insight into the molecular mechanisms underlying RA pathogenesis.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 2 disease state sets

Platform:: GPL8300
Series:: GSE10500
8 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3192

ID:: 3192

Select item 2000105002.

Gene expression in rheumatoid arthritis synovial macrophages

(Submitter supplied) Macrophages from RA synovial fluids were compared to primary human blood-derived macrophages. Keywords: disease state analysis

Organism:: Homo sapiens

Type:: Expression profiling by array

Dataset:: GDS3192
Platform:: GPL8300
8 Samples

Download data: CEL, CHP

Series

Accession:: GSE10500

ID:: 200010500

Select item 2000143863.

Interferon beta-1a-induced changes in gene expression in PBMCs derived from CIS patients

(Submitter supplied) IFNβ, an effective therapy against relapsing-remitting (RR) multiple sclerosis (MS) is naturally secreted during the innate immune response against viral pathogens. The objective of this study was to characterize the immunomodulatory mechanisms of IFNβ targeting innate immune response and their effects on DC-mediated regulation of T-cell differentiation. We found that IFNβ−1a in-vitro treatment of human monocyte-derived dendritic cells (DCs) induced the expression of TLR7 and the members of its downstream signaling pathway, including myeloid differentiation factor 88 (MyD88), IL-1R-associated kinase (IRAK)4, and TNF receptor-associated factor (TRAF)6, while it inhibited the expression of IL-1R. more...

Organism:: Homo sapiens

Type:: Expression profiling by array

Platform:: GPL570
30 Samples

Download data: CEL

Series

Accession:: GSE14386

ID:: 200014386

Select item 2001235124.

MEK1/2 inhibitors unlock the constrained interferon response in macrophages through IRF1 signaling

(Submitter supplied) Analysis of bone-marrow derived macrophages (BMDMs) stimulated with single or combinatorial TLR agonist and MEK1/2 inhibitor in wild-type and Irf1-/- macrophages. Results provide insights into the versatile but yet uncharacterized roles of IRF1 in TLR-MEK1/2-ERK MAPK signaling.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL20775
10 Samples

Download data: CEL, XLSX

Series

Accession:: GSE123512

ID:: 200123512

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000744075.

Epidermal Growth Factor Receptor inhibition triggers Type 1 Interferon signature in human keratinocytes

(Submitter supplied) The Epidermal Growth Factor Receptor (EGFR)/ligand system is centrally involved in multiple homeostatic functions of the epithelia. Epithelial cells are the primary targets of humanized antibodies and small molecule inhibitors against this system, whereby the constellation of skin-specific side effects of these drugs stems from a profound disturbance of keratinocyte biology. So far, the molecular mechanisms underlying these toxic events have been investigated only broadly. more...