Similar studies for GEO DataSets (Select 3195) - GEO DataSets

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Links from GEO DataSets

Items: 2

Select item 31951.

Hexose-6-phosphate dehydrogenase deficiency effect on skeletal muscles

Analysis of skeletal muscles from animals lacking hexose-6-phosphate dehydrogenase (H6PD). H6PD null animals develop severe skeletal myopathy characterized by switching of Type II to Type I fibers. Results provide insight into the molecular basis of the myopathy induced by the absence of H6PD.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 tissue sets

Platform:: GPL1261
Series:: GSE10347
12 Samples

Download data: CEL

DataSet

Accession:: GDS3195

ID:: 3195

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000103472.

Gene expression data from Hexose-6-phosphate dehydrogenase knockout mouse muscle at 4 weeks

(Submitter supplied) Hexose-6-phosphate dehydrogenase (H6PD)is the initial component of a pentose phosphate pathway inside the endoplasmic reticulum (ER) that generates NADPH for ER enzymes. In liver, H6PD is required for the 11-oxoreductase activity of 11ss-hydroxysteroid dehydrogenase type 1 (11ss-HSD1), which converts inactive 11-oxo glucocorticoids to their active 11-hydroxyl counterparts; consequently, H6PD null mice are relatively insensitive to glucocorticoids, exhibiting fasting hypoglycemia, increased insulin sensitivity despite elevated circulating levels of corticosterone, and increased basal and insulin-stimulated glucose uptake in muscles normally enriched in Type II (fast) fibers which have increased glycogen content. more...