Similar studies for GEO DataSets (Select 3253) - GEO DataSets

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Items: 20

Select item 32531.

MAP kinase PMK-1 and transcription factor DAF-16 deletion mutants

Analysis of daf-2(e1368) loss-of-function mutant and daf-2(e1368);pmk-1(km25) and daf-2(e1368);daf-16(mgDf47) double mutants. PMK-1 and DAF-16 confer enhanced pathogen resistance on daf-2 mutants relative to wild-type. Results suggest DAF-16 and PMK-1 upregulate distinct genes to promote immunity.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, count, 3 genotype/variation sets

Platform:: GPL200
Series:: GSE5801
9 Samples

Download data: CEL

DataSet

Accession:: GDS3253

ID:: 3253

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000058012.

Genes regulated by PMK-1 and DAF-16 in a daf-2(e1368) background.

(Submitter supplied) Analysis of genes differentially expressed between daf-2(e1368) and daf-2(e1368);pmk-1(km25) and between daf-2(e1368) and daf-2(e1368);daf-16(mgDf47). These studies identified genes upregulated by wild-type PMK-1 and wild-type DAF-16. Keywords: genetic modification

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS3253
Platform:: GPL200
9 Samples

Download data: CEL

Series

Accession:: GSE5801

ID:: 200005801

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000057933.

C. elegans gene expression in response to the pathogenic P. aeruginosa strain PA14.

(Submitter supplied) Analysis of differential gene expression in C. elegans adults exposed to three different bacteria: E. coli strain OP50, wild-type P. aeruginosa PA14 and gacA mutant PA14. Samples were analyzed at 4 hours and 8 hours after exposure to the different bacteria. These studies identified C. elegans genes induced by pathogen infection. Keywords: Time course, response to pathogen infection

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS3252
Platform:: GPL200
18 Samples

Download data: CEL

Series

Accession:: GSE5793

ID:: 200005793

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 32524.

Young adult response to Pseudomonas aeruginosa PA14: time course

Analysis of strain fer-15(b26);fem-1(hc17) young adults exposed for up to 8 hrs to pathogenic Pseudomonas aeruginosa strain PA14, less pathogenic PA14 mutant gacA, and E. coli strain OP50 (normal food source). Results provide insight into the molecular basis of the response to a bacterial pathogen.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, count, 3 infection, 2 time sets

Platform:: GPL200
Series:: GSE5793
18 Samples

Download data: CEL

DataSet

Accession:: GDS3252

ID:: 3252

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000134735.

Response of C. elegans immune pathway mutants to P. aeruginosa infection

(Submitter supplied) Synchronized C. elegans cultures of three geontypes -- wildype N2, daf-2(e1370) and sma-6(wk7) -- were prepared using standard techniques (http://cmgm.stanford.edu/~kimlab/index_methods.html). Live young adult worms were split between NG plates pre-seeded with the non-pathogenic E. coli strain OP50 or the Pseudomonas aeruginosa clinical isolate PA14 and incubated at 25C for 4 or 24 hours before harvesting. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

4 related Platforms
26 Samples

Download data: TXT

Series

Accession:: GSE13473

ID:: 200013473

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000412056.

Influence of p38 MAPK (PMK-1) on the heat stress response of C. elegans

(Submitter supplied) PMK-1 is involved in the heat stress response of C. elegans, translocates to the nucleus upon heat exposure and influences the expression of chaperone genes, proteasomal subunits and protein-biosynthesis related genes.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13657
2 Samples

Download data: TXT

Series

Accession:: GSE41205

ID:: 200041205

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 2000426897.

mek-1 and mlk-1 in fed or fasted condition

(Submitter supplied) Intermittent fasting is one of the most effective dietary restriction regimens that extend life-span in C. elegans and mammals. Fasting-stimulus responses are key to the longevity response; however, the mechanisms that sense and transduce fasting-stimulus have remained largely unknown. Through a comprehensive transcriptome analysis in C. elegans, we have found that along with the FOXO transcription factor DAF-16, AP-1 (JUN-1/FOS-1) plays a central role in fasting-induced transcriptional changes. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
10 Samples

Download data: CEL

Series

Accession:: GSE42689

ID:: 200042689

Select item 2000276778.

A conserved JNK/AP-1 module is a key mediator of intermittent fasting-induced longevity in C. elegans

(Submitter supplied) Dietary restriction extends lifespan and delays the age-related physiological decline in many species. Intermittent fasting (IF) is one of the most effective dietary restriction regimens that extends lifespan in C. elegans and mammals1,2. In C. elegans, the FOXO transcription factor DAF-16 is implicated in fasting-induced gene expression changes and the longevity response to IF3; however, the mechanisms that sense and transduce fasting-stress stimuli have remained largely unknown. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
46 Samples

Download data: CEL

Series

Accession:: GSE27677

ID:: 200027677

Select item 2000200539.

C. elegans gene expression in response to Y. pestis KIM5 infection

(Submitter supplied) The response of the nematode C. elegans to Y. pestis infection was evaluated by gene expression profiling. A synchronized population of nematodes were exposed to Y. pestis KIM5 for 24h. Transcript levels from Y. pestis-treated animals were compared with animals maintained on relatively nonpathogenic E. coli OP50 for 24h.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL200
6 Samples

Download data: CEL, CHP

Series

Accession:: GSE20053

ID:: 200020053

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20024449310.

RNA helicase HEL-1 promotes longevity by specifically activating DAF-16/FOXO transcription factor signaling in Caenorhabditis elegans

(Submitter supplied) The homeostatic maintenance of the genomic DNA is crucial for regulating aging processes. However, the role of RNA homeostasis in aging processes remains unknown. RNA helicases are a large family of enzymes that regulate the biogenesis and homeostasis of RNA. However, the functional significance of RNA helicases in aging has not been explored. Here, we report that a large fraction of RNA helicases regulate the lifespan ofCaenorhabditis elegans. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18245
8 Samples

Download data: TXT

Series

Accession:: GSE244493

ID:: 200244493

PubMed Full text in PMC Similar studies

Select item 20007242611.

daf-16/FoxO isoform-specific deletion mutants

(Submitter supplied) FoxO transcription factors promote longevity across taxa. How they do so is poorly understood. In the nematode Caenorhabditis elegans, the A- and F-isoforms of the FoxO transcription factor DAF-16 extend life span in the context of reduced DAF-2 insulin-like growth factor receptor (IGFR) signaling. To elucidate the mechanistic basis for DAF-16/FoxO-dependent life span extension, we performed an integrative analysis of isoform-specific daf-16/FoxO mutants. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13657
21 Samples

Download data: TXT

Series

Accession:: GSE72426

ID:: 200072426

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014644312.

Genome-wide profiling of age-dependent changes in gene expression between L4 larvae and Day 6 adult Caenorhabditis elegans

(Submitter supplied) Purpose: The objective of this study was to identify genes whose expression changes significantly between the L4 larval stage (Day 0 of adulthood) and the sixth day of adulthood (Day 6) in C. elegans. Methods: Wild type N2 animals were synchronized by sodium hypochlorite treatment and dropped as L1 larvae to NGM RNAi plates containing 2mM IPTG, 100 mg/mL carbenicillin and seeded with E. coli strain HT115 harboring the L4440 plasmid (vector only control for feeding-based RNAi experiments). more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18245
5 Samples

Download data: XLSX

Series

Accession:: GSE146443

ID:: 200146443

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20014467513.

NHR-8 regulated P-glycoproteins uncouple xenobiotic stress resistance from longevity in chemosensory C. elegans mutants

(Submitter supplied) Transcriptomics analysis of wild type and osm-3(dh441)IV under vehicle and tunicamycin treatment for 6 hours

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL25147
16 Samples

Download data: TXT

Series

Accession:: GSE144675

ID:: 200144675

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20024449414.

Reduced insulin/IGF1 signaling prevents immune aging via ZIP-10/bZIP–mediated feedforward loop

(Submitter supplied) A hallmark of aging is immunosenescence, a decline in immune functions, which appeared to be inevitable in living organisms, includingCaenorhabditis elegans. Here, we show that genetic inhibition of the DAF-2/insulin/IGF-1 receptor drastically enhances immunocompetence in old age inC. elegans. We demonstrate that longevity-promoting DAF-16/FOXO and heat-shock transcription factor 1 (HSF-1) increase immunocompetence in olddaf-2(−)animals. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18245
4 Samples

Download data: TXT

Series

Accession:: GSE244494

ID:: 200244494

PubMed Full text in PMC Similar studies

Select item 20013786115.

FOXO and HSF1 rejuvenate immunity via positive feedback regulation of insulin/IGF-1 signaling

(Submitter supplied) A hallmark of aging is immunosenescence, a decline in immune function that appeared to be inevitable. Surprisingly, here we show that genetic inhibition of DAF-2/insulin/IGF-1 receptor drastically delays immunosenescence and even rejuvenates immunity in C. elegans. We find that p38 mitogen activated protein kinase (PMK-1), a key determinant of immunosenescence in wild-type, is dispensable for this rejuvenated immunity. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL18245
12 Samples

Download data: TXT

Series

Accession:: GSE137861

ID:: 200137861

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20002185116.

Gene Expression Profiling of C. elegans - ets-4 Mutant Animals Vs Wild-type

(Submitter supplied) The gene expression profile of WT (N2) C. elegans were compared to that of ets-4(ok165) and ets-4(uz1) mutant animals

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS3747
Platform:: GPL7272
6 Samples

Download data: TXT

Series

Accession:: GSE21851

ID:: 200021851

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 374717.

Transcription factor ETS-4 deletion effect on larvae

Analysis of stage L4 larvae with two distinct deletion alleles of ets-4: ets-4(ok165) and ets-4(uz1). Adults with ets-4 mutations have a significant extension of mean life span. Results provide insight into the transcriptional control of aging effectors by the ETS-4 transcription factor.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, log2 ratio, 2 genotype/variation sets

Platform:: GPL7272
Series:: GSE21851
6 Samples

Download data: TXT

DataSet

Accession:: GDS3747

ID:: 3747

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 20002178418.

Genome-wide expression analysis during aging in C. elegans

(Submitter supplied) Aging has been shown to be under genetic control in C. elegans. We performed Affymetrix micorarray-based transcriptional profililng of wild type C. elegans strain Bristol N2 during aging to detect temporal changes in gene expression.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Dataset:: GDS3943
Platform:: GPL200
9 Samples

Download data: CEL

Series

Accession:: GSE21784

ID:: 200021784

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 394319.

Effect of aging on nematode

Analysis of C.elegans at 3 points during aging: late larval L4 stage, days 6 and 15 of adulthood. C. elegans exhibits increased susceptibility to bacterial infection with age. Results provide insight into molecular mechanisms underlying the decline in immune function with aging (immunosenescence).