Similar studies for GEO DataSets (Select 3313) - GEO DataSets

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Items: 2

Select item 33131.

Tibolone hormone effect on postmenopausal endometrium

Comparison of endometria after short-term treatment with tibolone, estradiol (E2), or E2 + medroxyprogesterone acetate (E2 + MPA) in healthy postmenopausal women undergoing hysterectomy. A synthetic steroid, Tibolone is used as an alternative for estrogen or estrogen/progesterone hormone therapy.

Organism:: Homo sapiens

Type:: Expression profiling by array, count, 4 agent sets

Platform:: GPL570
Series:: GSE12446
31 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS3313

ID:: 3313

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000124462.

Endometrium of hormone-treated postmenopausal women

(Submitter supplied) Title: Transcriptome analysis of human endometrial tissues from healthy post-menoupausal women reflecting the endometrial response to 3-weeks treatment with tibolone, E2 and E2+MPA. In an observational, open, non-randomized, controlled study uterine tissues were collected in order to generate endometrial gene expression profiles. healthy postmenopausal women were enrolled into the following treatment groups: Control-group; Tibolone-group, 2,5 mg of tibolone (administered orally) every day, starting 21 days prior to surgery; Estradiol-group, 2 mg of estradiol (administered orally) every day, starting 21 days prior to surgery; Estradiol+progestagen-group, 2 mg of estradiol (administered orally) and 5 mg of MPA (Medroxy Progesteroneacetate, administered orally) every day, starting 21 days prior to surgery. more...